A5042095965- Multiple Sclerosis Research Studies
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Arrest and Resuscitation
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Long-Term Effects of COVID-19
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Family and Disability Support Research
- Autoimmune and Inflammatory Disorders Research
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Genetic Neurodegenerative Diseases
- Effects of Vibration on Health
- Trauma and Emergency Care Studies
- COVID-19 and Mental Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Behavioral and Psychological Studies
- Resilience and Mental Health
- Neurogenesis and neuroplasticity mechanisms
Rutgers, The State University of New Jersey
2016-2025
Kessler Foundation
2016-2025
Rutgers New Jersey Medical School
2015-2024
Newark Academy
2022
Foundation Center
2021
Children's Specialized Hospital
2020
Istituto Nazionale di Fisica Nucleare, Sezione di Genova
2015
University Hospital, Newark
2009
Kessler Institute for Rehabilitation
2006-2008
The present study investigated the neural correlates of cognitive fatigue in Multiple Sclerosis (MS), looking specifically at relationship between self-reported and objective measures fatigue. In Experiment 1, functional magnetic resonance imaging (fMRI) was used to examine where brain BOLD activity covaried with "state" fatigue, assessed during performance a task designed induce while scanner. 2, diffusion tensor (DTI) white matter damage correlated increased "trait" individuals MS, by...
The present study used fMRI (functional magnetic resonance imaging) to objectively assess cognitive fatigue in persons with traumatic brain injury (TBI). It was hypothesized that while performing a task, TBI participants would show increased activity over time, indicative of cerebral 'effort' which might manifest as the subjective feeling fatigue.Functional MRI track across time 11 patients moderate-severe and age-matched healthy controls (HCs) performed modified Symbol Digit Modalities Task...
Although it is known that processing speed deficits are one of the primary cognitive impairments in multiple sclerosis (MS), underlying neural mechanisms responsible for impaired remain undetermined. Using BOLD functional magnetic resonance imaging, current study compared brain activity 16 individuals with MS to 17 healthy controls (HCs) during performance a task, modified version Symbol Digit Modalities Task. there were no differences accuracy, group was significantly slower than HCs. both...
The objective of this paper is to investigate the interrelationship between subjective and cognitive fatigue, information processing domain [processing speed (PS) vs. working memory (WM)], load (high low), time on task in Multiple Sclerosis (MS).Thirty-two MS participants 24 healthy controls completed experimental tasks both PS WM domains with different levels load. Subjective fatigue was measured using a visual analog scale at baseline multiple points throughout experiment.A mixed model...
Traumatic brain injury (TBI) often results in impairments cognitive skills as well depression. As a result of these changes cognition and mood, individuals with TBI may reduce their levels participation report reduced health-related quality life (HrQOL). The current study compares past present activity between healthy participants persons using client-centred approach measurement. We additionally examine the relationship participation, emotional functioning HrQOL TBI. Fifty-two who live...
Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear be cognitive and potentially comprise "fatigue network". These include the striatum basal ganglia, dorsolateral prefrontal cortex (DLPFC), dorsal anterior cingulate (dACC), ventro-medial (vmPFC) insula. However, no been conducted assess whether connectivity between these changes as function fatigue. We used task-based...
To explore the added value of dynamic functional connectivity (dFC) default mode network (DMN) during resting-state (RS), an information processing speed (IPS) task, and within-subject difference between these conditions, on top conventional brain measures in explaining IPS people with multiple sclerosis (pwMS). In 29 pwMS 18 healthy controls, was assessed Letter Digit Substitution Test Stroop Card I combined into IPS-composite score. White matter (WM), grey (GM) lesion volume were measured...
Head movement during functional magnetic resonance imaging (fMRI) degrades data quality. The effects of small movements can be ameliorated postprocessing, but associated with severe is frequently discarded. In discarding these data, it often assumed that head-movement a source random error, and discarded from subjects without biasing the sample. We tested this assumption by examining whether head was related to task difficulty cognitive status among persons multiple sclerosis (MS)....
The primary purpose of the current study was to examine relationship between performance on executive tasks and white matter integrity, assessed by diffusion tensor imaging (DTI) in multiple sclerosis (MS). A second aim how processing speed affects functioning fractional anisotropy (FA). This examined two that rely heavily speed: Color–Word Interference Test Trail Making (Delis–Kaplan Executive Function System). It hypothesized reduced FA is related poor MS, but this would be affected...
Emotional processing deficits have recently been identified in individuals with traumatic brain injury (TBI), specifically the domain of facial affect recognition. However, neural networks underlying these impairments yet to be identified. In current study, 42 moderate severe TBI and 23 healthy controls performed a task recognition (Facial Emotion Identification Test (FEIT)) order assess their ability identify discriminate six emotions: happiness, sadness, anger, surprise, shame, fear. These...
We investigated differences in brain activation associated with cognitive fatigue between persons traumatic injury (TBI) and healthy controls (HCs). Twenty-two participants moderate-severe TBI 20 HCs performed four blocks of a difficult working memory task control during fMRI imaging. Cognitive fatigue, assessed before after each block, was used as covariate to assess fatigue-related activation. The group reported more than the HCs, though their performance comparable. Regarding activation,...
Fatigue is commonly thought to worsen with age, but the literature mixed: some studies show that older individuals experience more fatigue, others report reverse. Some inconsistencies in may be related gender differences fatigue while due instruments used study since correlation between state (in moment) and trait (over an extended period of time) measures has been shown weak. The purpose current was examine both across age using neuroimaging self-report data. We investigated effects 43...