A5053874473- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- EEG and Brain-Computer Interfaces
- Mental Health Research Topics
- Face Recognition and Perception
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetic Neurodegenerative Diseases
- Attention Deficit Hyperactivity Disorder
- Neurological Disease Mechanisms and Treatments
- Memory Processes and Influences
- Neurobiology of Language and Bilingualism
- Psychosomatic Disorders and Their Treatments
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- Visual perception and processing mechanisms
- Psychology of Moral and Emotional Judgment
Leiden University
2016-2025
Leiden University Medical Center
2016-2025
Antwerp University Hospital
2006-2025
Erasmus MC
2017-2022
Amsterdam Neuroscience
2022
University Medical Center
2022
University College London
2022
UK Dementia Research Institute
2022
Netherlands Institute for Neuroscience
2011-2020
Czech Academy of Sciences, Institute of Psychology
2011-2019
Functional MRI (fMRI) can be applied to study the functional connectivity of human brain. It has been suggested that fluctuations in blood oxygenation level-dependent (BOLD) signal during rest reflect neuronal baseline activity brain, representing state brain absence goal-directed action and external input, these slow correspond functionally relevant resting-state networks. Several studies on resting fMRI have conducted, reporting an apparent similarity between identified patterns. The...
Although it is being successfully implemented for exploration of the genome, discovery science has eluded functional neuroimaging community. The core challenge remains development common paradigms interrogating myriad systems in brain without constraints a priori hypotheses. Resting-state MRI (R-fMRI) constitutes candidate approach capable addressing this challenge. Imaging during rest reveals large-amplitude spontaneous low-frequency (<0.1 Hz) fluctuations fMRI signal that are temporally...
Normal aging is associated with cognitive decline. Functions such as attention, information processing, and working memory are compromised. It has been hypothesized that not only regional changes, but also alterations in the integration of brain activity (functional connectivity) underlie observed age-related deficits. Here, we examined functional properties networks based on spontaneous fluctuations within systems using magnetic resonance imaging. We connectivity intrinsic "default-mode"...
Abstract Activity and reactivity of the default mode network in brain was studied using functional magnetic resonance imaging (fMRI) 28 nondemented individuals with mild cognitive impairment (MCI), 18 patients Alzheimer's disease (AD), 41 healthy elderly controls (HC). The interrogated by means decreases activity, termed deactivations, during a visual encoding task nonspatial working memory task. Deactivation found involving anterior frontal, precuneus, posterior cingulate cortex. MCI showed...
Local network connectivity disruptions in Alzheimer's disease patients have been found using graph analysis BOLD fMRI. Other studies MEG and cortical thickness measures, however, show more global long distance changes, both functional structural imaging data. The form role of changes thus remains ambiguous. current study shows conclusive data on early AD resting-state condition fMRI data.18 mild 21 healthy age-matched control subjects without memory complaints were investigated with MRI at...
Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about third of patients, the disease caused by autosomal dominant genetic mutations usually in one three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9orf72). Findings from studies other dementias have shown neuroimaging and cognitive changes before symptoms onset, we aimed to identify whether such could be frontotemporal dementia.
The relation between brain development across adolescence and adolescent risky behavior has attracted increasing interest in recent years. It been proposed that adolescents are hypersensitive to reward because of an imbalance the developmental pattern followed by striatum prefrontal cortex. To date, it is unclear if engage they overestimate potential rewards or respond more received whether these effects occur absence decisions. In this study, we used a functional magnetic resonance imaging...
Curiosity is one of the most basic biological drives in both animals and humans, has been identified as a key motive for learning discovery. Despite importance curiosity related behaviors, topic largely neglected human neuroscience; hence little known about neurobiological mechanisms underlying curiosity. We used functional magnetic resonance imaging (fMRI) to investigate what happens our brain during induction subsequent relief perceptual Our core findings were that (i) curiosity, through...
Abstract Objective To evaluate cerebrospinal fluid ( CSF ) and serum neurofilament light chain (NfL) levels in genetic frontotemporal dementia FTD as a potential biomarker the presymptomatic stage during conversion into symptomatic stage. Additionally, to correlate NfL clinical neuroimaging parameters. Methods In this multicenter case–control study, we investigated 174 subjects (48 controls, 40 carriers 86 patients with microtubule‐associated protein tau MAPT ), progranulin GRN chromosome 9...
Structural brain markers are studied extensively in the field of neurodegeneration, but thought to occur rather late process. Functional measures such as functional connectivity gaining interest potentially more subtle neurodegeneration. However, structure and function also affected by 'normal' ageing. More information is needed on how relates aging, particularly absence overt neurodegenerative disease. We investigated association age with resting-state 2878 non-demented persons between 50...
Lesion studies have shown convincingly that the medial temporal lobes (MTL) and frontal are critical to episodic memory. Ageing generally has been found a negative effect on memory performance, which might relate neurofunctional changes in brain regions. In present study, we used functional MRI (fMRI) investigate separately contributions of encoding retrieval age-related decline To this end, compared activity patterns obtained during incidental (pleasant/unpleasant judgements about nouns)...
Although subjective complaints about daytime cognitive functioning are an essential symptom of chronic insomnia, abnormalities in functional brain activation have not previously been investigated. This study was designed to investigate differences as a possible result and the reversibility these after nonmedicated sleep therapy.Insomniacs carefully matched controls underwent magnetic resonance imaging (fMRI) scanning during performance category letter fluency task. Insomniacs were randomly...
Abstract The pattern of degenerative changes in the brain white matter (WM) aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD) has been under debate. Methods image analysis are an important factor affecting outcomes various studies. Here we used diffusion tensor imaging (DTI) to obtain fractional anisotropy (FA) measures WM healthy young ( n = 8), elderly 22), MCI AD patients 16). We then applied “tract‐based spatial statistics” (TBSS) study effects MCI, on integrity. Our...
fMRI, a noninvasive technique to measure brain activation, is gaining clinical interest, because its sensitivity enables individual assessments. However, more insight in the reproducibility of these measurements during higher cognitive tasks necessary. We performed an fMRI study involving within- and between-subject encoding complex visual pictures. Ten healthy subjects were studied on three occasions: twice same scanning session (study 1 2), third time, 3-24 days later 3). On all 30...