A5034391900- Amyotrophic Lateral Sclerosis Research
- Reading and Literacy Development
- Neurological diseases and metabolism
- Inflammatory Bowel Disease
- Health Systems, Economic Evaluations, Quality of Life
- Early Childhood Education and Development
- Prion Diseases and Protein Misfolding
- Vector-Borne Animal Diseases
- Urological Disorders and Treatments
- Viral Infections and Vectors
- Sexual function and dysfunction studies
- Microscopic Colitis
- Parkinson's Disease Mechanisms and Treatments
- Vector-borne infectious diseases
- Microfluidic and Capillary Electrophoresis Applications
- Parental Involvement in Education
- Dementia and Cognitive Impairment Research
- Gene expression and cancer classification
- Cancer Treatment and Pharmacology
- Genomics and Rare Diseases
- Eosinophilic Esophagitis
- Delphi Technique in Research
- HER2/EGFR in Cancer Research
- Economic and Financial Impacts of Cancer
- Mobile Health and mHealth Applications
Velindre NHS Trust
2024
Velindre Cancer Centre
2024
King's College London
2023-2024
Anglia Ruskin University
2022-2024
Animal and Plant Health Agency
2023
National Hospital for Neurology and Neurosurgery
2017-2018
UK Dementia Research Institute
2016-2018
University College London
2016-2018
Abstract Objective To evaluate cerebrospinal fluid ( CSF ) and serum neurofilament light chain (NfL) levels in genetic frontotemporal dementia FTD as a potential biomarker the presymptomatic stage during conversion into symptomatic stage. Additionally, to correlate NfL clinical neuroimaging parameters. Methods In this multicenter case–control study, we investigated 174 subjects (48 controls, 40 carriers 86 patients with microtubule‐associated protein tau MAPT ), progranulin GRN chromosome 9...
In patients with frontotemporal dementia, it has been shown that brain atrophy occurs earliest in the anterior cingulate, insula and frontal lobes. We used visual rating scales to investigate whether identifying these areas may be helpful distinguishing symptomatic carrying different causal mutations microtubule-associated protein tau (MAPT), progranulin (GRN) chromosome 9 open reading frame (C9ORF72) genes. also analysed asymptomatic carriers see was possible visually identify before...
The Rose Report (Rose, Independent review of the primary curriculum (England); 2009) outlined a set recommendations for management dyslexia in United Kingdom after range issues were found. Despite these recommendations, recent reports indicate that are still prevalent diagnosis process and support offered dyslexic children. Delphi method was employed to gain parental consensus as most significant barriers delivery children with dyslexia, well solutions overcoming barriers. Parents school...
Abstract Introduction Mutations in the TANK‐binding kinase 1 ( TBK1 ) gene have recently been shown to cause frontotemporal dementia (FTD). However, phenotype of ‐associated FTD is currently unclear. Methods We performed a single case longitudinal study patient who was subsequently found novel A705fs mutation gene. He assessed annually over 7‐year period with series clinical, cognitive, and magnetic resonance imaging assessments. His brain underwent pathological examination at postmortem....
Co-morbid anxiety and depression (distress) in inflammatory bowel disease (IBD) results poorer outcomes increased healthcare burden. IBD services require scalable treatment pathways for distress to meet this need. This real-world longitudinal study evaluates the implementation of a new integrated care pathway including: 1) routine mental health screening 2) therapist-guided, digital CBT tailored challenges living with (compass adaptations IBD: COMPASS-IBD) UK National Health Service (NHS)...
Babesiosis, a disease in humans and animals is caused by piroplasms from the genus Babesia transmitted ixodid ticks. Bovine babesiosis, commonly called redwater fever, reported cattle many regions of British Isles. The presence questing ticks United Kingdom (UK) its potential impact on public animal health has not been widely studied. Therefore, this study aimed to assess spp. England Wales using collected over six-year period. Questing Ixodes ricinus nymphs were at 20 recreational areas...
Sindbis virus (SINV) is the causative agent of a febrile infection commonly called Ockelbo disease, Pogosta disease or Karelian fever in northern Europe. Finland, Sweden, Russia and South Africa experience periodic SINV outbreaks. classified within family Togaviridae genus Alphavirus. Symptoms humans include joint inflammation pain, fever, rash fatigue. In some cases, symptoms can persist for years after recovery from initial infection. Clinical signs are rarely reported animals, although...
Introduction: Co-morbid anxiety and depression (distress) in inflammatory bowel disease (IBD) results poorer outcomes increased healthcare burden. IBD services require scalable treatment pathways for distress to meet this need. This study aims evaluate the feasibility of implementing a new integrated care pathway including: 1) routine mental health screening 2) therapist-guided, digital CBT tailored challenges living with (compass adaptations IBD: COMPASS-IBD) large gastroenterology service...
vial residues considered as stable for 14 days (about 7400 € during the observation period). This study showed also that eribulin was correctly prescribed and exhibited a good tolerance profile considering low percentage of delayed prescriptions (3/292) dose modifications (12/292). Conclusions: An extended stability limit (14 days) compared to 24-hr period recommended by manufacturer should lead significant cost savings. The results be confirmed inclusion other patients hospitals. However,...
“Ageing in Place” remains the Holy Grail for aged care planning despite advances made healthcare, home technology, housing design and healthcare financing. It requires coordinated, multipronged efforts from policy, research practice to re-engineer ecosystem where people live, work, play age. One such re-engineering project has been initiated by Tsao Foundation, a Singapore-based but regionally oriented non-governmental organisation, 2013. This symposium showcases Foundation’s ground-up,...
The primary progressive aphasias (PPA) are clinically, anatomically and pathologically diverse, leading to considerable nosological diagnostic difficulties. A number of patients with PPA do not meet current consensus criteria for any the three canonical variants (logopenic aphasia, LPA; nonfluent variant PPA, nfvPPA; or semantic svPPA). This raises key issue as whether strategies in need be reviewed, prospect disease modifying therapies treatment trials these devastating diseases. Here we...
The Rose Report (Rose, 2009) outlined a set of recommendations for the management dyslexia in U.K after range issues were found. Despite these recommendations, recent reports, and review on SEND provision indicates that are still prevalent process diagnosis support dyslexic children. Delphi method was employed to gain parental consensus as most significant barriers delivery children with dyslexia, well solutions important overcoming barriers. Parents primary school recruited study presented...