Maria Carmela Tartaglia
A5015941834- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Prion Diseases and Protein Misfolding
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Cerebral Palsy and Movement Disorders
- Systemic Lupus Erythematosus Research
- Neurological diseases and metabolism
- Cerebrospinal fluid and hydrocephalus
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Multiple Sclerosis Research Studies
- Genetic Neurodegenerative Diseases
- Cardiac Arrest and Resuscitation
- Advanced MRI Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Neurobiology of Language and Bilingualism
- Neuroinflammation and Neurodegeneration Mechanisms
- Folate and B Vitamins Research
- Health, Environment, Cognitive Aging
University of Toronto
2016-2025
University Health Network
2016-2025
Occupational Cancer Research Centre
2016-2025
Toronto Western Hospital
2016-2025
Ontario Brain Institute
2020-2025
Women's Brain Project
2020-2025
University of California, San Francisco
2009-2024
Discovery Centre
2015-2024
Munich Cluster for Systems Neurology
2024
Ludwig-Maximilians-Universität München
2022-2024
<h3>Objective</h3> To assess axonal damage and its contribution to disability at different stages of multiple sclerosis (MS). <h3>Background</h3> Recent in vivo imaging situ pathologic studies have demonstrated that substantial accompanies the inflammatory lesions MS. However, relation duration MS disease remain poorly defined. <h3>Design</h3> We performed proton magnetic resonance spectroscopic 88 patients with a wide range clinical measure<i>N</i>-acetylaspartate (NAA, an index integrity)...
Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about third of patients, the disease caused by autosomal dominant genetic mutations usually in one three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9orf72). Findings from studies other dementias have shown neuroimaging and cognitive changes before symptoms onset, we aimed to identify whether such could be frontotemporal dementia.
Abstract The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct trajectories. Here we introduce machine-learning technique—Subtype Stage Inference (SuStaIn)—able uncover data-driven with temporal progression patterns, from widely available cross-sectional patient studies. Results imaging studies in two reveal subgroups their trajectories regional...
Primary progressive aphasia is a clinical syndrome that encompasses three major phenotypes: non-fluent/agrammatic, semantic and logopenic. These entities have been associated with characteristic patterns of focal grey matter atrophy in left posterior frontoinsular, anterior temporal temporoparietal regions, respectively. Recently, network-level dysfunction has hypothesized but research to date focused largely on studying damage. The aim this study was assess the integrity white tracts...
Accurately predicting the underlying neuropathological diagnosis in patients with behavioural variant frontotemporal dementia (bvFTD) poses a daunting challenge for clinicians but will be critical success of disease-modifying therapies. We sought to improve pathological prediction by exploring clinicopathological correlations large bvFTD cohort. Among 438 whom was either top or an alternative possible clinical diagnosis, 117 had available autopsy data, including 98 primary lobar degeneration...
We examined recovery from postconcussion syndrome (PCS) in a series of 285 patients diagnosed with concussion based on international sport criteria who received questionnaire regarding recovery. Of 141 respondents, those symptoms lasting less than 3 months, positive computed tomography (CT) and/or magnetic resonance imaging (MRI), litigants, and known Test Memory Malingering (TOMM)-positive cases were excluded, leaving 110 eligible respondents. found that only 27% our population eventually...
Abstract Objective To evaluate cerebrospinal fluid ( CSF ) and serum neurofilament light chain (NfL) levels in genetic frontotemporal dementia FTD as a potential biomarker the presymptomatic stage during conversion into symptomatic stage. Additionally, to correlate NfL clinical neuroimaging parameters. Methods In this multicenter case–control study, we investigated 174 subjects (48 controls, 40 carriers 86 patients with microtubule‐associated protein tau MAPT ), progranulin GRN chromosome 9...
There are few validated fluid biomarkers in frontotemporal dementia (FTD). Glial fibrillary acidic protein (GFAP) is a measure of astrogliosis, known pathological process FTD, but has yet to be explored as potential biomarker.Plasma GFAP and neurofilament light chain (NfL) concentration were measured 469 individuals enrolled the Genetic FTD Initiative: 114 C9orf72 expansion carriers (74 presymptomatic, 40 symptomatic), 119 GRN mutation (88 31 53 MAPT (34 19 symptomatic) 183 non-carrier...
<h3>Importance</h3> Neurofibrillary tangles composed of aggregated tau protein are one the neuropathological hallmarks Alzheimer disease (AD) and correlate with clinical severity. Monoclonal antibodies targeting may have potential to ameliorate AD progression by slowing or stopping spread and/or accumulation pathological tau. <h3>Objective</h3> To evaluate safety efficacy monoclonal anti-tau antibody semorinemab in prodromal mild AD. <h3>Design, Setting, Participants</h3> This phase 2...
<h3>Background</h3> Fatigue is a common and distressing symptom for patients with multiple sclerosis (MS). There growing evidence that fatigue in MS has central nervous system component. We hypothesized diffuse cerebral axonal damage could be associated used proton magnetic resonance spectroscopy to noninvasively measure or loss the brains of MS. <h3>Objective</h3> To assess strength relationship between brain<i>N</i>-acetylaspartate fatigue. <h3>Design</h3> Data from 73 who had undergone...
Background: Although in situ pathological studies and vivo magnetic resonance (MR) investigations have shown that axonal injury can be significant the early stages of multiple sclerosis (MS), diffuse is generally considered a secondary event.Cerebral damage specifically assessed by measuring levels brain N-acetylaspartate (NAA, specific index integrity detected MR spectroscopy).Other new measurements such as magnetization transfer ratio (MTr) or computed estimation volume provide less...
Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes. In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed among 3 common forms FTD (mutations in C9orf72, GRN, MAPT). Participants from the Genetic Initiative (GENFI) cohort suitable volumetric T1 magnetic resonance imaging scan included (319): 144 nonmutation carriers, 128 presymptomatic mutation 47 clinically affected carriers. Cross-sectional GM volume between...
Clinical diagnosis of Alzheimer's disease (AD) prior to the age 65 years is classified as young-onset (YOAD), whereas after considered late-onset (LOAD). Although rare autosomal mutations more commonly associate with YOAD, most YOAD and LOAD cases are sporadic. share amyloid tau pathology, but many patients show increased severity rate progression. The current study examined microRNA (miRNA) expression profile from exosomes isolated cerebrospinal fluid (CSF) biomarker-confirmed AD. Results...
Chronic traumatic encephalopathy (CTE) is the term coined for neurodegenerative disease often suspected in athletes with histories of repeated concussion and progressive dementia. Histologically, CTE defined as a tauopathy distribution tau-positive neurofibrillary tangles (NFTs) that distinct from other tauopathies, usually shows an absence beta-amyloid deposits, contrast to Alzheimer's (AD). Although connection between concussions CTE-type neurodegeneration has been recently proposed, this...
OBJECTIVE The objective of this study was to determine the demographics and predictors postconcussion syndrome (PCS) in a large series patients using novel definition PCS. METHODS authors conducted retrospective cohort 284 consecutive concussed patients, 221 whom had PCS on basis at least 3 symptoms persisting 1 month. This uniformly employed is unique accepting an expanded list symptoms, shortening interval month from months, excluding those with focal injuries such as hemorrhages...
Transactive response DNA-binding protein 43 (TDP-43) is a major pathological in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). There are many disease-associated mutations TDP-43, several cellular animal models with ectopic overexpression of mutant TDP-43 have been established. Here we sought to study altered molecular events FTD ALS by using induced pluripotent stem cell (iPSC) derived patient neurons. We generated multiple iPSC lines from an FTD/ALS the TARDBP A90V...
The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generated multiple induced pluripotent stem cell lines from a control subject, patient with sporadic FTD, and an FTD novel heterozygous GRN mutation (progranulin [PGRN] S116X). In neurons microglia differentiated PGRN S116X cells, the levels intracellular secreted were reduced, establishing patient-specific cellular models haploinsufficiency. Through systematic screen inducers stress, found that...
<h3>Background</h3> Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer9s disease (AD) and mild cognitive impairment (MCI) criteria. However, previous studies have failed to detect alterations species other primary tauopathies. We assessed protein abnormalities AD, tauopathy with prominent Aβ pathology, progressive supranuclear palsy (PSP), characterised by deposition four microtubule-binding repeat (4R) minimal pathology. <h3>Methods</h3> 26 normal...
The frontotemporal cortical network is associated with behaviours such as impulsivity and aggression. health of the uncinate fasciculus (UF) that connects orbitofrontal cortex (OFC) anterior temporal lobe (ATL) may be a crucial determinant behavioural regulation. Behavioural changes can emerge after repeated concussion thus we used MRI to examine UF connected gray matter it relates aggression in retired professional football players who had sustained multiple concussions. Behaviourally,...