A5085508118- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Traumatic Brain Injury Research
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- S100 Proteins and Annexins
- Neuroblastoma Research and Treatments
- Cardiac Arrest and Resuscitation
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Telomeres, Telomerase, and Senescence
- Fetal and Pediatric Neurological Disorders
- RNA regulation and disease
- Muscle Physiology and Disorders
- Neurological Disease Mechanisms and Treatments
- Chromatin Remodeling and Cancer
- Prion Diseases and Protein Misfolding
McGill University
2021-2025
University of Toronto
2015-2024
Hospital for Sick Children
2013-2024
SickKids Foundation
2008-2023
Toronto Western Hospital
2012-2022
University Health Network
2007-2022
Canada Research Chairs
2021-2022
Systems, Applications & Products in Data Processing (Canada)
2021
CancerCare Manitoba
2021
University of Manitoba
2021
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features manifesting LRRK2 mutation carriers generally indistinguishable from those patients with sporadic PD. However, some PD cases associated mutations lack Lewy bodies (LBs), a neuropathological hallmark We investigated whether presence or absence LBs correlates different LRRK2-related PD.We describe genetic, clinical, and findings 37 including 33...
We examined recovery from postconcussion syndrome (PCS) in a series of 285 patients diagnosed with concussion based on international sport criteria who received questionnaire regarding recovery. Of 141 respondents, those symptoms lasting less than 3 months, positive computed tomography (CT) and/or magnetic resonance imaging (MRI), litigants, and known Test Memory Malingering (TOMM)-positive cases were excluded, leaving 110 eligible respondents. found that only 27% our population eventually...
Abstract The organization of the efferent connections subthalamic nucleus was studied in squirrel monkey ( Saimiri sciureus ) by using lectin Phaseolus vulgaris ‐leucoagglutinin (PHA‐L) as an anterograde tracer. At level basal forebrain, anterogradely labeled fibers and axon terminals were mostly found striatopallidal complex substantia innominata. In cases which PHA‐L injection sites placed central or lateral third nuclus, numerous seen to arise from loci innervate massively globus...
Clinical case reports of parkinsonism co-occurring with hemizygous 22q11.2 deletions and the associated multisystem syndrome, deletion syndrome (22q11.2DS), suggest that may lead to increased risk early-onset Parkinson disease (PD). The frequency PD its neuropathological presentation remain unknown in this common genetic condition.To evaluate a possible association between PD.An observational study occurrence world's largest cohort well-characterized adults molecularly confirmed diagnosis...
Chronic traumatic encephalopathy (CTE) is the term coined for neurodegenerative disease often suspected in athletes with histories of repeated concussion and progressive dementia. Histologically, CTE defined as a tauopathy distribution tau-positive neurofibrillary tangles (NFTs) that distinct from other tauopathies, usually shows an absence beta-amyloid deposits, contrast to Alzheimer's (AD). Although connection between concussions CTE-type neurodegeneration has been recently proposed, this...
Well-formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH PD is unknown but may involve structures mediating processing such as the inferior temporal cortex. Serotonergic type 2A (5-HT(2A)) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5-HT(2A) receptor levels be involved PD. Autoradiographic binding using [(3)H]-ketanserin and spiperone, define receptors, was performed...
Multiple system atrophy (MSA) is a neurodegenerative disease leading to severe physical impairment, with duration from onset death of 6-9 years.The clinical and neuropathological features 4 MSA cases 15 years or more were analyzed.All patients presented parkinsonism had mean latency 11 before the development dysautonomia. Mean first symptoms anterocollis, inspiratory stridor, dysphagia was 9 years. Despite limited levodopa response, all developed levodopa-induced dyskinesia.Late appearance...
PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes current chemoradiotherapy strategies. Our aim was to study the role of targeted inhibition in these tumors. PATIENTS AND METHODS We collected clinical, imaging, molecular, and outcome information from patients V600E–mutated glioma treated across 29 centers multiple countries. RESULTS Sixty-seven were (pediatric low-grade [PLGGs], n = 56; high-grade [PHGGs], 11) for up 5.6 years. Objective responses...
Mild traumatic brain injury (mTBI) is an important public health issue, as it can lead to long-term neurological symptoms and risk of neurodegenerative disease. The pathophysiological mechanisms driving this remain unclear, currently there are no effective therapies for mTBI. In study on repeated mTBI (rmTBI), we have induced three mild closed-skull injuries or sham procedures, separated by 24 h, in C57BL/6 mice. We show that rmTBI mice prolonged righting reflexes astrogliosis, with...
Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of aggregated tau proteins in astrocytes, neurons, and oligodendrocytes. Previous genome-wide association studies for PSP were based on genotype array, therefore, inadequate analysis variants as well larger mutations, such small insertions/deletions (indels) structural (SVs). Method In this study, we performed whole genome sequencing (WGS) conducted single nucleotide...
Sorting mechanisms that cause the amyloid precursor protein (APP) and β-secretases γ-secretases to colocalize in same compartment play an important role regulation of Aβ production Alzheimer's disease (AD). We others have reported genetic variants Sortilin-related receptor (SORL1) increased risk AD, SORL1 is involved trafficking APP, underexpression leads overproduction Aβ. Here we explored one its homologs, sortilin-related VPS10 domain containing 1 (SORCS1), AD.We analyzed associations...
OBJECTIVE To estimate the allele frequency of C9orf72 (G4C2) repeats in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer disease (AD), and Parkinson (PD). DESIGN The number was estimated by a 2-step genotyping strategy. For expansion carriers, we sequenced repeat flanking regions obtained APOE genotypes MAPT H1/H2 haplotypes. SETTING Hospitals specializing neurodegenerative disorders. SUBJECTS We analyzed 520 patients with FTLD, 389 ALS, 424 AD, 289...
<h3>Background and Objectives</h3> The macroscopic anatomy of a common paraneural sheath that surrounds the sciatic nerve in popliteal fossa has been studied recently human cadaveric study. It suggested an injection through this could be ideal location for local anesthetic administration block. aim present study was to evaluate hypothesis blockade results shorter onset time when compared with conventional postbifurcation external tissue. To illustrate microscopic tissues, we performed...