A5013274485- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Trace Elements in Health
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Botulinum Toxin and Related Neurological Disorders
- Heavy Metal Exposure and Toxicity
- RNA regulation and disease
- Infectious Encephalopathies and Encephalitis
- Autism Spectrum Disorder Research
- Neurological and metabolic disorders
- Virology and Viral Diseases
- Genomics and Rare Diseases
- Aluminum toxicity and tolerance in plants and animals
- Restless Legs Syndrome Research
- Muscle activation and electromyography studies
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Vaccine Coverage and Hesitancy
- Lysosomal Storage Disorders Research
- Syphilis Diagnosis and Treatment
- Extraction and Separation Processes
- Genetic Associations and Epidemiology
- Neurogenetic and Muscular Disorders Research
Bangalore Diabetes Centre
2015-2025
Manipal Hospital
2022-2025
St. Joseph Dental College
2024
All India Institute of Medical Sciences Rishikesh
2022-2023
John Wiley & Sons (United States)
2023
MedStar Georgetown University Hospital
2022
Georgetown University
2022
Vikram Hospital
2019-2021
Parkinson's Foundation
2021
Deleted Institution
2021
Multiple system atrophy (MSA) is a neurodegenerative disease leading to severe physical impairment, with duration from onset death of 6-9 years.The clinical and neuropathological features 4 MSA cases 15 years or more were analyzed.All patients presented parkinsonism had mean latency 11 before the development dysautonomia. Mean first symptoms anterocollis, inspiratory stridor, dysphagia was 9 years. Despite limited levodopa response, all developed levodopa-induced dyskinesia.Late appearance...
Therapeutic outcome of Wilson's disease (WD) significantly depends upon its early recognition. However, because rarity in community and protean manifestations, the diagnosis treatment are often delayed.To ascertain diagnostic errors at initial evaluation these patients.Analysis medical records 307 patients WD registered over 30 years was done regarding presenting omissions, interval between onset symptoms to treatment.Of by referring doctors from different specialties health care were...
Recently, symptoms similar to addictive drug withdrawal have been reported in a structured longitudinal study of patients with idiopathic Parkinson's Disease (PD) withdrawing from dopamine agonists (DA): the agonist syndrome (DAWS).The objective this was establish frequency, predictors, and outcomes DAWS movement disorders clinic.We conducted retrospective chart review sample clinical diagnosis PD treated DA whom or attempted carried out because adverse effects, for any other reason. Out 487...
Magnetic resonance imaging (MRI) is frequently used in the evaluation of various extrapyramidal disorders. Among plethora MRI features Wilson's disease (WD), only "face giant panda" sign has been recognized to distinguish WD from other early onset disorders (EOEPD). To ascertain value differentiating neuropsychiatric form EOEPD. This retrospective analysis included 100 patients (M:F = 56:44) EOEPD (5-40 years), who had undergone during Jan'03 Nov'08. Their clinical were recorded and...
Abstract The facial phenotype of psychogenic movement disorders has not been fully characterized. Seven tertiary‐referral centers using a standardized data collection on computerized database performed retrospective chart review involving the face. Patients with organic forms dystonia or any medical neurological disorder known to affect muscles were excluded. Sixty‐one patients fulfilled inclusion criteria for (91.8% females; age: 37.0 ± 11.3 years). Phasic tonic muscular spasms resembling...
Abstract The benefits of large-scale genetic studies for healthcare the populations studied are well documented, but these have traditionally ignored people from some parts world, such as South Asia. Here we describe whole genome sequence (WGS) data 4806 individuals recruited delivery systems Pakistan, India and Bangladesh, combined with WGS 927 isolated Asian populations. We characterize population structure in Asia a genotyping array (SARGAM) imputation reference panel that optimized...
The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic clinical data for use in large-scale analyses to dramatically expand our understanding of architecture PD. This report details workflow cohort integration into complex arm GP2, together with outline monogenic hub a companion paper, provides generalizable blueprint establishing large scale collaborative research consortia.
Wilson's disease (WD) is clinically and radiologically a dynamic disorder. However, there paucity of studies involving sequential MRI changes in this with or without therapy This study looked at serial their clinical correlate patients WD The severity using 1.5 T 50 was graded based on alteration signal intensity focal lesions atrophy. Details manifestations, Schwab England Activities daily living (MSEADL) score, Neurological Symptom Score (NSS) Chu staging were recorded. Clinical disability...
ABSTRACT Background Glial cytoplasmic inclusions containing α‐synuclein are the pathological hallmark of multiple system atrophy (MSA). Minimal change (MC‐MSA) is an unusual MSA subtype with neuronal loss largely restricted to substantia nigra and locus coeruleus. Methods Immunohistochemistry on selected brain regions semiquantitative assessment were performed six MC‐MSA eight control cases. Results More seen in caudate than controls ( P = 0.002), without any statistical difference glial...
Abstract Growing evidence suggests that non-motor symptoms (NMS) in Parkinson’s disease (PD) have differential progression patterns a different natural history from motor and may be geographically influenced. We conducted cross-sectional analysis of 1607 PD patients whom 1327 were Europe, 208 the Americas, 72 Asia. The primary objective was to assess baseline burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying factors predicting quality life,...
Abstract Background Recent studies have advanced our understanding of the genetic drivers Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and latest PD genome‐wide association study (GWAS) identified 90 independent risk loci. However, there remains a gap genetics outside European populations which vast majority these were focused. Objective The aim was to identify factors South Asian population. Methods A total 674 subjects predominantly with age...
Clinical and laboratory characteristics of 39 patients with adult onset subacute sclerosing panencephalitis (SSPE) are described compared to those juvenile regarding preceding measles, age at onset, gender, interval between diagnosis, clinical profile, course during follow up. Diagnosis was based on electroencephalographic findings raised anti-measles antibody titres in cerebrospinal fluid. Mean SSPE symptom 20.9±4.9 years mean from diagnosis 6.3±9.6 months. Referral accurate only 12...
Background: Wilson's disease (WD), a metabolic disorder, is believed to be potentially reversible, even in its severe form. However, some patients do not respond treatment.
Behavioral and psychiatric abnormalities in Wilson's disease (WD) have a variable frequency spectrum. This study involved evaluation of the comorbidities patients disease, using structured clinical interview for DSM-IV Axis-I disorders (SCID). Among 50 confirmed with recruited this study, 12 (24%) fulfilled diagnostic criteria syndromic diagnosis: bipolar affective disorder (18%), major depression (4%), dysthymia (2%). Formal assessment psychopathology all may therapeutic significance.