A5086704861- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Restless Legs Syndrome Research
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Lysosomal Storage Disorders Research
- Hereditary Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Prion Diseases and Protein Misfolding
- Ginkgo biloba and Cashew Applications
- Balance, Gait, and Falls Prevention
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Autism Spectrum Disorder Research
- Autophagy in Disease and Therapy
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Wuxi Fourth People's Hospital
2025
Jiangnan University
2025
Shanxi Medical University
2025
Guangzhou University of Chinese Medicine
2025
Institute for Neurodegenerative Disorders
2021-2024
Hua Medicine (China)
2024
National Institute of Mental Health and Neurosciences
2023-2024
The Royal College Of Anesthesiologists Of Thailand
2024
Neurodegeneration with brain iron accumulation (NBIA) defines a group of genetic disorders characterized by deposition and associated neuronal death. The known causes NBIA include pantothenate kinase-associated neurodegeneration (PKAN), neuroferritinopathy, infantile neuroaxonal dystrophy (INAD), aceruloplasminemia.To define the radiologic features each subtype.Brain MRIs from patients molecularly confirmed PKAN (26 cases), neuroferritinopathy (21 INAD (four aceruloplasminemia (10 cases)...
This study aimed to determine the mutational spectrum of familial Parkinson's disease and sporadic early-onset (sEOPD) in a mainland Chinese population clinical features mutation carriers. We performed multiplex ligation-dependent probe amplification assays whole-exome sequencing for 1676 unrelated patients with population, including 192 probands from families autosomal-recessive disease, 242 autosomal-dominant 1242 sEOPD (age at onset ≤ 50). According standards guidelines American College...
Emerging evidence has suggested a close correlation between COVID-19 and neurodegenerative disorders. However, whether there exists causal association the effect direction remains unknown. To examine causative role of in risk disorders, we estimated their genetic correlation, then conducted two-sample Mendelian randomization analysis using summary statistics from genome-wide studies susceptibility, hospitalization, severity COVID-19, as well six major disorders including Alzheimer's disease...
Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies performed in just one population at a time. Here we large-scale multi-ancestry meta-analysis of with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals European, East Asian, Latin American African ancestry. In meta-analysis, 78 significant loci, 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2,...
Genome-wide association studies (GWAS) on Parkinson's disease (PD) have mostly been done in Europeans and Japanese. No study has Han Chinese, which make up nearly a fifth of the world population. We conducted first Chinese GWAS analysing total 22,729 subjects (5,125 PD cases 17,604 controls) from Singapore, Hong Kong, Malaysia, Korea, mainland China Taiwan. performed imputation, merging logistic regression analyses 2,402,394 SNPs passing quality control filters 779 cases, 13,227 controls,...
Abstract In recent years, biomarkers have been integrated into the diagnostic process and become increasingly indispensable for obtaining knowledge of neurodegenerative processes in Alzheimer’s disease (AD). Peripheral blood mononuclear cells (PBMCs) human reported to participate a variety activities. Here, single-cell RNA sequencing analysis PBMCs from 4 AD patients (2 early stage, 2 late stage) normal controls was performed explore differential cell subpopulations patients. A significant...
Reactive astrogliosis has been demonstrated to have a role in Parkinson's disease (PD); however, astrocyte-specific plasma glial fibrillary acidic protein (GFAP)'s correlation with PD progression remains unknown. We aimed determine whether GFAP can monitor and predict progression.A total of 184 patients 95 healthy controls (HCs) were included this prospective cohort study followed-up for 5 years. Plasma GFAP, amyloid-beta (Aβ), p-tau181, neurofilament light chain (NfL) measured at baseline...
Abstract Parkinson’s disease (PD) is a heterogeneous movement disorder with different motor subtypes including tremor dominant (TD), indeterminate and postural instability, gait disturbance (PIGD) subtypes. Plasma glial fibrillary acidic protein (GFAP) was elevated in PD patients may be regarded as biomarker for cognitive progression. Here we explore if there an association between plasma GFAP whether baseline level can predict subtype conversion. Patients classified TD, PIGD or underwent...
Abstract Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple atrophy, diagnosis established requires manifestation dysfunction in with poorly...
<h3>Objective</h3> This study used resting-state functional MRI (fMRI) to evaluate regional and network alterations in patients with Parkinson9s disease (PD) without depression. <h3>Method</h3> We recruited 29 PD depression (PD-Dep), 30 (PD-NDep), normal controls. All participants underwent fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) blood oxygen level-dependent signals was characterise cerebral function. Functional integration the brain evaluated by...
Significance Parkinson’s disease (PD) is the second most common neurodegenerative disorder in world. Several and rare genetic risk variants associated with PD pathogenesis have been identified, predominantly persons of European descent, but contributions to familial are largely unknown for Han Chinese. Here, we present a trio-based study explore association between de novo-altered genes early onset We found that 12 novo mutations were biologically connected each other likely be disease-risk...
Abstract Background The nature and frequency of nonmotor symptoms in primary adult‐onset cervical dystonia ( CD ) blepharospasm BSP patients Chinese populations remain unknown. Methods Hamilton's Depression Scale HAMD ), Anxiety HAMA Addenbrooke's Cognitive Examination Revised ACE ‐R), Pittsburgh Sleep Quality Index Epworth Sleepiness were used to evaluate NMS 120 with focal (60 60 age‐, sex‐, education level‐ matched healthy controls HC s). Motor evaluated by Jankovic rating scale Toronto...