A5009278015- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Traumatic Brain Injury Research
- Posttraumatic Stress Disorder Research
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Psychosomatic Disorders and Their Treatments
- Advanced Mathematical Physics Problems
- Autism Spectrum Disorder Research
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Xiamen University
2024-2025
Zhejiang University
2013-2025
Guangzhou University of Chinese Medicine
2025
Zhujiang Hospital
2025
Southern Medical University
2025
University of Maryland, College Park
2023-2024
Guangxi University of Science and Technology
2023-2024
Most of what we know about antipsychotic drug effects is at the receptor level, distal from neural system that mediate their clinical efficacy. Studying cerebral function in antipsychotic-naive patients with schizophrenia before and after pharmacotherapy can enhance understanding therapeutic mechanisms these clinically effective treatments.To examine alterations regional network first-episode treatment second-generation medication.Case-control study.Huaxi MR Research Center Mental Health...
Objective: The authors used resting-state functional connectivity MRI to evaluate brain networks in patients with refractory and nonrefractory major depressive disorder. Method: In a cross-sectional study, 28 depression, 32 48 healthy comparison subjects underwent scanning using gradient-echo echo-planar imaging sequence on 3-T MR system. Thirteen regions of interest that have been identified the literature as relevant mood regulation were selected seed areas. A reference time series was...
The purpose of the present study was to characterize association between clinical symptoms and anatomical functional cerebral deficits in a relatively large sample antipsychotic-naive first-episode schizophrenia patients using optimized voxel-based morphometry resting state connectivity analysis.Participants were 68 matched healthy comparison subjects. Both subjects scanned volumetric three-dimensional spoiled gradient recall sequence gradient-echo echo-planar imaging sequence....
Abstract The large majority of structural MRI studies major depressive disorder (MDD) investigated volumetric changes in chronic medicated patients whom course illness and treatment effects may impact anatomic measurements. Further, few studies, separate measurements cortical thickness surface area have been performed that reflect different neurobiological processes regulated by genetic mechanisms. In the present study, we both first-episode, treatment-naïve, mid-life MDD to elucidate core...
Strong evidence implicates prefrontal cortex (PFC) as a major source of functional impairment in severe mental illness such schizophrenia. Numerous schizophrenia studies report deficits PFC structure, activation, and connectivity patients with chronic illness, suggesting that deficient occurs this disorder. However, the patterns during onset its longitudinal progression remain uncharacterized. Emerging suggests early-course involves increased glutamate, which might elevate connectivity. To...
<h3>Importance</h3> Accumulating evidence supports the hypothesis that cerebral white matter abnormalities are involved in pathophysiology of schizophrenia; however, findings from vivo neuroimaging studies have been inconsistent. Besides confounding factors, including age, illness duration, and medication effects, an additional cause for inconsistent results may be heterogeneity nature alterations associated with disorder. <h3>Objective</h3> To investigate whether different patterns exist a...
The authors sought to explore whether anatomical and functional brain deficits are present in similar or different regions early the course of schizophrenia, before antipsychotic treatment, these more severe otherwise patients with prominent negative symptoms. A total 100 drug-naive first-episode schizophrenia matched healthy comparison subjects underwent structural resting-state MRI scanning. Gray matter volume amplitude low-frequency fluctuations during studies were measured. Group...
Purpose To use resting-state functional magnetic resonance (MR) imaging and graph theory approaches to systematically investigate the topological organization of connectome patients with posttraumatic stress disorder (PTSD). Materials Methods This study was approved by research ethics committee, all subjects provided informed consent for participation. Seventy-six PTSD caused an earthquake 76 control who experienced same disaster were matched age, sex, years education. The underwent MR...
Objective: Suicide is a major social and public health problem, but its neurobiology in depressive disorder poorly understood. The purpose of this study was to use magnetic resonance diffusion tensor imaging characterize abnormalities white matter integrity patients with without history suicide attempts. Method: Participants were 52 disorder, (N=16) (N=36) attempts, healthy comparison subjects matched for age, gender, education, ethnicity. Diffusion 3.0 Tesla scanner performed. Whole-brain...
Besides the enormous medical and economic consequences, national disasters, such as Wenchuan 8.0 earthquake, also pose a risk to mental health of survivors. In this context, better understanding is needed how functional brain systems adapt severe emotional stress. Previous animal studies have demonstrated importance limbic, paralimbic, striatal, prefrontal structures in stress fear responses. Human studies, which focused primarily on patients with clinically established posttraumatic...
Purpose To identify cerebral radiomic features related to diagnosis and subtyping of attention deficit hyperactivity disorder (ADHD) build evaluate classification models for ADHD on the basis identified features. Materials Methods A consecutive cohort 83 age- sex-matched children with newly diagnosed never-treated (mean age 10.83 years ± 2.30; range, 7–14 years; 71 boys, 40 ADHD-inattentive [ADHD-I] 43 ADHD-combined [ADHD-C, or inattentive hyperactive]) 87 healthy control subjects age, 11.21...