A5003407293- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Neural and Behavioral Psychology Studies
- Autism Spectrum Disorder Research
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- EEG and Brain-Computer Interfaces
- Substance Abuse Treatment and Outcomes
- Mental Health and Psychiatry
- Congenital heart defects research
- Health, Environment, Cognitive Aging
- Behavioral Health and Interventions
- Bipolar Disorder and Treatment
Yale University
2016-2025
Connecticut Mental Health Center
2014-2025
University of Ljubljana
2022-2023
National Center for PTSD
2016-2023
VA Connecticut Healthcare System
2023
TU Dresden
2022
Baylor College of Medicine
2022
Ljubljana University Medical Centre
2022
National Institute on Alcohol Abuse and Alcoholism
2011-2022
University Psychiatric Hospital
2022
Control of thought and behavior is fundamental to human intelligence. Evidence suggests a frontoparietal brain network implements such cognitive control across diverse contexts. We identify mechanism--global connectivity--by which components this might coordinate other networks. A lateral prefrontal cortex (LPFC) region's activity was found predict performance in high demand working memory task also exhibit global connectivity. Critically, connectivity LPFC region, involving connections both...
Schizophrenia is a devastating neuropsychiatric syndrome associated with distributed brain dysconnectivity that may involve large-scale thalamo-cortical systems. Incomplete characterization of thalamic connectivity in schizophrenia limits our understanding its relationship to symptoms and diagnoses shared clinical presentation, such as bipolar illness, which exist on spectrum. Using resting-state functional magnetic resonance imaging, we characterized 90 patients versus matched controls via:...
Studies of large-scale brain organization have revealed interesting relationships between spatial gradients in maps across multiple modalities. Evaluating the significance these findings requires establishing statistical expectations under a null hypothesis interest. Through generative modeling synthetic data that instantiate specific hypothesis, quantitative benchmarks can be derived for arbitrarily complex measures. Here, we present model, provided as an open-access software platform,...
Significance This study identified elevated global brain signal variability in schizophrenia, but not bipolar illness. was related to schizophrenia symptoms. A commonly used analytic procedure neuroimaging, regression, attenuated clinical effects and altered inferences. Furthermore, local voxel-wise variance increased independent of regression. Finally, neurobiologically grounded computational modeling suggests a putative mechanism, whereby overall connection strength may underlie observed...
The large-scale organization of dynamical neural activity across cortex emerges through long-range interactions among local circuits. We hypothesized that dynamics are also shaped by heterogeneity intrinsic properties cortical areas. One key axis along which microcircuit specialized relates to hierarchical levels organization. developed a circuit model human incorporates synaptic strengths, following inferred from magnetic resonance imaging (MRI)-derived T1- T2-weighted (T1w/T2w) mapping and...
Severe neuropsychiatric conditions, such as schizophrenia, affect distributed neural computations. One candidate system profoundly altered in chronic schizophrenia involves the thalamocortical networks. It is widely acknowledged that a neurodevelopmental disorder likely affects brain before onset of clinical symptoms. However, no investigation has tested whether connectivity individuals at risk for psychosis or this pattern more severe who later develop full-blown illness.To determine...
Background: Lysergic acid diethylamide (LSD) has agonist activity at various serotonin (5-HT) and dopamine receptors. Despite the therapeutic scientific interest in LSD, specific receptor contributions to its neurobiological effects remain unknown. Methods: We therefore conducted a double-blind, randomized, counterbalanced, cross-over studyduring which 24 healthy human participants received either (i) placebo+placebo, (ii) placebo+LSD (100 µg po), or (iii) Ketanserin, selective 5-HT2A...
Glutamatergic neurotransmission mediated by N -methyl- d -aspartate (NMDA) receptors is vital for the cortical computations underlying cognition and might be disrupted in severe neuropsychiatric illnesses such as schizophrenia. Studies on this topic have been limited to processes local circuits; however, involves large-scale brain systems with multiple interacting regions. A prominent feature of human brain’s global architecture anticorrelation default-mode vs. task-positive systems. Here,...
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
Abstract Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict onset of psychosis and distinguish patients from healthy controls, regardless paradigm. Here, using multi-paradigm fMRI data North American Prodrome Longitudinal Study consortium, we show individuals at high risk for display an intrinsic...