A5001094886- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Psychedelics and Drug Studies
- Mast cells and histamine
- Treatment of Major Depression
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Body Image and Dysmorphia Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Eating Disorders and Behaviors
- Neuroendocrine regulation and behavior
- Attention Deficit Hyperactivity Disorder
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Chemical synthesis and alkaloids
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Genetic Associations and Epidemiology
- Olfactory and Sensory Function Studies
Yale University
2016-2025
Multidisciplinary Association for Psychedelic Studies
2023
ORCID
2022
Massachusetts General Hospital
2014-2020
University at Buffalo, State University of New York
2020
New Haven Public Schools
2019
National Center for PTSD
2018
The University of Texas Health Science Center at Houston
2017
Michigan Medicine
2017
Michigan United
2017
Significance This study identified elevated global brain signal variability in schizophrenia, but not bipolar illness. was related to schizophrenia symptoms. A commonly used analytic procedure neuroimaging, regression, attenuated clinical effects and altered inferences. Furthermore, local voxel-wise variance increased independent of regression. Finally, neurobiologically grounded computational modeling suggests a putative mechanism, whereby overall connection strength may underlie observed...
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify attributable all interrogated variants. We have quantified variance liability disease explained by SNPs for two phenotypically-related neurobehavioral disorders, obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), using GCTA. Our analysis yielded point estimate 0.58 (se = 0.09, p 5.64e-12) TS, 0.37...
Abstract A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartate receptor (NMDAR) antagonists such as act preferentially on GABAergic neurons. However, cortical interneurons are heterogeneous. particular, somatostatin-expressing (SST) selectively inhibit dendrites regulate synaptic inputs, yet their response to systemic NMDAR antagonism is...
We have constructed a strain of Saccharomyces cerevisiae with deletion the YKL510 open reading frame, which was initially identified in chromosome XI as homolog RAD2 nucleotide excision repair gene (A. Jacquier, P. Legrain, and B. Dujon, Yeast 8:121-132, 1992). The mutant exhibits increased sensitivity to UV light alkylating agent methylmethane sulfonate but not ionizing radiation. renamed frame RAD27 gene, keeping accepted nomenclature for radiation-sensitive yeast mutants. Epistasis...
Anxiety is a core human emotion but can become pathologically dysregulated. We used functional magnetic resonance imaging (fMRI) neurofeedback (NF) to noninvasively alter patterns of brain connectivity, as measured by resting-state fMRI, and reduce contamination anxiety. Activity region the orbitofrontal cortex associated with anxiety was in real time provided subjects significant subclinical NF signal, permitting them learn modulate target region. altered network connectivity regions...