Amalia Guerrero‐Pedraza
A5036025060- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
- Mental Health Research Topics
- Genetic Associations and Epidemiology
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Hemispheric Asymmetry in Neuroscience
- Face Recognition and Perception
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Music Perception
- Tryptophan and brain disorders
- Identity, Memory, and Therapy
- Evolutionary Psychology and Human Behavior
- Diet and metabolism studies
- Attention Deficit Hyperactivity Disorder
- Neural dynamics and brain function
- Hallucinations in medical conditions
- Neural and Behavioral Psychology Studies
- Fetal and Pediatric Neurological Disorders
Hospital Mare de Déu de la Mercè
2016-2024
Fidmag Sisters Hospitallers
2012-2024
Cambridgeshire and Peterborough NHS Foundation Trust
2021
Universidad de Cádiz
2021
Universitätsklinikum Aachen
2019
RWTH Aachen University
2019
Centro de Investigación Biomédica en Red de Salud Mental
2015
Universitat Autònoma de Barcelona
2011
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
A relatively large number of studies have investigated the power structural magnetic resonance imaging (sMRI) data to discriminate patients with schizophrenia from healthy controls. However, very few them also included bipolar disorder, allowing clinically relevant discrimination between both psychotic diagnostics. To assess efficacy sMRI for diagnostic prediction in psychosis we objectively evaluated discriminative a wide range commonly used machine learning algorithms (ridge, lasso,...
The profiles of cortical abnormalities in schizophrenia and bipolar disorder, how far they resemble each other, have only been studied to a limited extent. aim this study was identify compare the changes morphology associated with these pathologies.A total 384 subjects, including 128 patients schizophrenia, disorder 127 sex-age-matched healthy were examined using surface-based morphology. Four structural measures studied: volume (CV), thickness (CT), surface area (SA) gyrification index...
Patients with schizophrenia are known to have increased prevalence of abnormalities in midline brain structures, such as a failure the septum pellucidum fuse (cavum pellucidum) and absence adhesio interthalamica. This is first study investigate these across large multidiagnostic sample. Presence cavum interthalamica was assessed 639 patients chronic schizophrenia, delusional disorder, schizoaffective bipolar major depressive or episode psychosis, mania unipolar depression. compared 223...
Magnetic resonance imaging (MRI) has been proposed as a source of information for automatic prediction individual diagnosis in schizophrenia. Optimal integration data from different MRI modalities is an active area research aimed at increasing diagnostic accuracy. Based on sample 96 patients with schizophrenia and matched 115 healthy controls that had undergone single multimodal session, we generated brain maps gray matter vbm, 1back, 2back levels activation (nback fMRI), amplitude...
Given the shared ectodermal origin and integrated development of face brain, facial biomarkers emerge as potential candidates to assess vulnerability for disorders in which neurodevelopment is compromised, such Schizophrenia (SZ) bipolar disorder (BD). The sample comprised 188 individuals (67 SZ patients, 46 BD patients 75 healthy controls (HC)). Using a landmark-based approach on 3D reconstructions, we quantified global local shape differences between SZ/BD HC using geometric morphometrics....
Background It is not known whether first-episode psychosis characterized by the same prefrontal cortex functional imaging abnormalities as chronic schizophrenia. Method Thirty patients with a first episode of non-affective and 28 healthy controls underwent magnetic resonance (fMRI) during performance n-back working memory task. Voxel-based analyses brain activations deactivations were carried out compared between groups. The connectivity regions significant difference was also examined....
Abstract Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited group-level analyses, small and selective samples inpatients long time lags between exposure outcome. Methods This cross-sectional study pooled data from 20 sites participating the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted diffusion-weighted...
An alteration in self/other differentiation has been proposed as a basis for several symptoms schizophrenia, including delusions of reference and social functioning deficits. Dysfunction the right temporo-parietal junction (TPJ), region linked with cognition, this alteration. However, imaging studies self- other-processing schizophrenia have shown, so far, inconsistent results. Patients healthy controls underwent fMRI scanning while performing task three conditions: self-reflection,...
The experience of auditory verbal hallucinations (AVH, “hearing voices”) in schizophrenia has been found to be associated with reduced cortex activation during perception real stimuli like tones and speech. We re-examined this finding using 46 patients (23 frequent AVH 23 hallucination-free), who underwent fMRI scanning while they heard words, sentences reversed Twenty-five matched healthy controls were also examined. Perception speech all elicited the bilateral superior temporal cortex,...
Abstract Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, whether this was clinical characteristics a prospective meta-analytic study conducted by the ENIGMA Working Group. The included data from 26 cohorts worldwide, total 2803 patients (mean age 34.2 years; range 18-72 67% male) 2598 healthy controls 33.8 years, 18-73 55%...
Individuals with schizophrenia exhibit greater inter-patient variability in functional brain activity during neurocognitive task performance. Some studies have shown associations of age and illness duration function; however, the association these variables function is not known. In order to better understand progressive effects across disorders, we examined relationship individual activity.Neuroimaging behavioural data were extracted from harmonized datasets collectively including 212...
Introduction: Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted alogia) amotivation/pleasure (MAP) (anhedonia, asociality). The aim of this article was examine potential sex differences among first-episode schizophrenia (FES) patients analyze sex-related predictors NS factors (EXP MAP) functional outcome. Material Methods:...
The brain functional correlates of autobiographical recall are well established, but have been little studied in schizophrenia. Additionally, memory is one a small number cognitive tasks that activates rather than de-activates the default mode network, which has found to be dysfunctional this disorder.Twenty-seven schizophrenic patients and 30 healthy controls underwent magnetic resonance imaging while viewing cue words evoked memories. Control conditions included both non-memory-evoking...
Included in the neurotrophins family, Neuritin 1 gene (NRN1) has emerged as an attractive candidate for schizophrenia (SZ) since it been associated with risk disorder and general cognitive performance. In this work, we aimed to further investigate association of NRN1 SZ by exploring its role on age at onset brain activity correlates. First, developed two genetic analyses using a family-based sample (80 early-onset (EO) trios (offspring ≤ 18 years) 71 adult-onset (AO) trios) independent...
Abstract Auditory verbal hallucinations (AVH, ‘hearing voices’) are an important symptom of schizophrenia but their biological basis is not well understood. One longstanding approach proposes that they perceptual in nature, specifically reflect spontaneous abnormal neuronal activity the auditory cortex, perhaps with additional ‘top down’ cognitive influences. Functional imaging studies employing capture technique—where when patients experience AVH compared to times do not—have had mixed...
Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases poorly understood. Previous research, mainly focused on emotional face and recognition deficits, has shown controverted results. Furthermore, the use faces been questioned for not entailing an appropriate stimulus to study processing. This highlights importance investigating abnormalities using evocative stimuli. For first time, we have studied brain responses scenic stimuli patients with...