Francesca Assogna
A5008991810- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Functional Brain Connectivity Studies
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Dementia and Cognitive Impairment Research
- Attention Deficit Hyperactivity Disorder
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Schizophrenia research and treatment
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Neurobiology of Language and Bilingualism
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Vestibular and auditory disorders
- Advanced Glycation End Products research
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2023
Fondazione Santa Lucia
2014-2023
Center for Translational Research in Neuroimaging and Data Science
2020
Georgia Institute of Technology
2020
University of California, Irvine
2020
Enrico Fermi Center for Study and Research
2017-2019
Amsterdam UMC Location Vrije Universiteit Amsterdam
2019
Sunovion (United States)
2019
Sapienza University of Rome
2012
Anna Needs Neuroblastoma Answers
2012
One objective of modern neuroimaging is to identify markers that can aid in diagnosis, disease progression monitoring and long-term drug impact analysis. In this study, Parkinson-associated physiopathological modifications were characterized six subcortical structures by simultaneously measuring quantitative magnetic resonance parameters sensitive complementary tissue characteristics (i.e. volume atrophy, iron deposition microstructural damage). Thirty patients with Parkinson's 22 control...
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
Attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), and obsessive-compulsive (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these using structural brain imaging data from ENIGMA consortium data.
Investigating in a case-control study whether the performance scores of group patients with Parkinson disease (PD) without dementia on tests declarative memory could be predicted by hippocampal volume reduction (as assessed automatic segmentation cerebral magnetic resonance [MR] images) or rate microstructural alterations evaluated diffusion tensor analysis MR images).Twenty-five individuals PD and 25 matched healthy control subjects underwent 3-T MRI protocol whole-brain T1-weighted imaging...
ABSTRACT Background Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective Using a multicenter approach and harmonized analysis methods, we aimed shed light on stage‐specific profiles pathology, as suggested by in vivo neuroimaging. Methods Individual brain MRI clinical data from 2357 patients 1182 healthy controls were collected 19 sources. We analyzed regional cortical thickness, surface area, subcortical volume using...
No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures cortical thickness, surface area subcortical volume tested classification performance cross-validation. Classification vs. complete sample different classifiers cross-validation strategies was...
Freezing of Gait (FoG) is a common symptom in Parkinson’s Disease (PD) occurring with significant variability and severity associated increased risk falls. FoG detection everyday life not trivial, particularly patients manifesting the only specific conditions. Various wearable devices have been proposed to detect PD symptoms, primarily based on inertial sensors. We here report results validation novel system pair pressure insoles equipped 3D accelerometer episodes. Twenty attended motor...
Microstructural alterations in cortico-subcortical connections are thought to be present obsessive-compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power detect subtle abnormalities. Here we investigated microstructural white matter and their relation clinical features the largest dataset of adult pediatric OCD date. We analyzed diffusion tensor imaging metrics from 700 patients 645 controls, as...
Abstract Microstructural analyses by MRI brain scans and DTI analysis of MR images were used to investigate the possible relationship between deep gray matter structures (amygdala hippocampus) dreaming in healthy subjects. Thirty‐four subjects ranging age 20s 70s underwent a protocol for assessment volume mean diffusivity (MD) amygdala hippocampus asked fill out dream diary via audiotape recording upon morning awakening two weeks. Multiple regression evaluated relationships anatomical...
Background Mobile health, predominantly wearable technology and mobile apps, have been considered in Parkinson disease to provide valuable ecological data between face-to-face visits improve monitoring of motor symptoms remotely. Objective We explored the feasibility using a technology-based mHealth platform comprising smartphone combination with smartwatch pair smart insoles, described this study as PD_manager system, collect clinically meaningful data. also outcomes disease-related factors...
Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.Nevertheless, the potential impact of age on plasma has not yet been systematically examined.In present study, we quantified a focused panel ceramides dihydroceramides cohort 164 subjects (84 women) 19 to 80 years age.After adjusting for confounders, multivariable linear regression analysis revealed positive association between (d18:1/24:0) (β (SE)...
Background: The coronavirus disease 2019 (COVID-19) pandemic had a great impact on patients with cognitive decline or dementia. lockdown period may exacerbate behavioral disorders and worsen distress of caregivers. aim this study is to evaluate the effectiveness family support intervention negative effects that COVID-19 have related Methods: We recruited whose caregivers attended course before lockdown. was for members dementia consisted in eight meetings during which participants received...
The role of inflammation in Parkinson’s Disease (PD) is well appreciated, but its underlying mechanisms are still unclear. Our objective was to determine whether dendritic cells (DC), a unique type migratory immune that regulate immunological response and have an impact on PD. In case-control study including 80 PD patients age- gender-matched healthy control subjects, the two main blood subsets plasmacytoid myeloid DC were defined by flow cytometry analysis. Clinical evaluation subjects...
A recent publication reported an exciting polygenic effect of schizophrenia (SCZ) risk variants, identified by a large genome-wide association study (GWAS), on total brain and white matter volumes in schizophrenic patients and, even more prominently, healthy subjects. The aim the present work was to replicate then potentially extend these findings. According original publication, scores-using single nucleotide polymorphism (SNP) information SCZ GWAS-(polygenic scores; PSS) were calculated...
Abstract Background Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non‐motor functioning remain be elucidated. Objective To quantify cross‐sectional lobule volumes using three dimensional T1‐weighted anatomical brain magnetic resonance imaging from global ENIGMA‐PD working group. Methods Cerebellar parcellation was performed deep learning‐based approach 2487 people PD 1212...