Rosa Ayesa‐Arriola
A5011508137- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Cannabis and Cannabinoid Research
- Genetics and Neurodevelopmental Disorders
- Mental Health Treatment and Access
- COVID-19 Impact on Reproduction
- Attention Deficit Hyperactivity Disorder
- Obsessive-Compulsive Spectrum Disorders
- Suicide and Self-Harm Studies
- Diet and metabolism studies
- Infant Development and Preterm Care
- Cognitive Abilities and Testing
- Dementia and Cognitive Impairment Research
- Family Caregiving in Mental Illness
- COVID-19 and Mental Health
- Treatment of Major Depression
Centro de Investigación Biomédica en Red de Salud Mental
2016-2025
Marqués de Valdecilla University Hospital
2016-2025
Instituto de Investigación Marqués de Valdecilla
2016-2025
Universidad de Cantabria
2016-2025
Instituto de Salud Carlos III
2016-2025
National University of Distance Education
2022-2025
Biomedical Research Institute
2020-2024
Universitat de Lleida
2023
Institut de Biomedicina de la Universitat de Barcelona
2022
Spanish Clinical Research Network
2022
<h3>Importance</h3> Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these is not well understood. <h3>Objective</h3> To determine neurobiologic correlates of between cases and controls 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), bipolar (BD), major depressive (MDD), obsessive-compulsive (OCD), schizophrenia. <h3>Design, Setting,...
The two hemispheres of the human brain differ functionally and structurally. Despite over a century research, extent to which asymmetry is influenced by sex, handedness, age, genetic factors still controversial. Here we present largest ever analysis subcortical asymmetries, in harmonized multi-site study using meta-analysis methods. Volumetric seven structures was assessed 15,847 MRI scans from 52 datasets worldwide. There were sex differences globus pallidus putamen. Heritability estimates,...
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
Objective Impaired cognitive function has been identified as a core feature of schizophrenia. However, significant proportion patients do not show any deficits. The aim this study was to assess if there were differences in white matter integrity between with and without impairment. Method A diffusion tensor imaging neurocognitive assessment conducted 49 first-episode psychosis 41 healthy comparison subjects. Subjects assessed using the Continuous Performance Test, Grooved Pegboard Rey...
Prisons are major reservoirs of hepatitis C virus (HCV) in which a therapeutic approach has been particularly difficult so far. Our aim was to create permanent program HCV elimination prison based on "test and treat" strategy.This open-label clinical trial conducted the Spanish "El Dueso" between May 2016 July 2017. Viremic patients were treated with ledipasvir-sofosbuvir regimen (8-12 weeks) according 2015 Guidelines. A teleconsultation established follow-up from hospital. Non-responders...
• We present Neuroharmony, a harmonization tool for images from unseen scanners. developed Neuroharmony using total of 15,026 sMRI images. The was able to reduce scanner-related bias scans. represents significant step towards imaging-based clinical tools. is available at https://github.com/garciadias/Neuroharmony .
In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with early stages of psychosis in hope that these could aid prediction onset and clinical outcome. Despite advancements field, has yet to deliver. This is part explained by use univariate analytical techniques, small samples lack statistical power, external validation potential biomarkers, integration nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN an international,...
Different effectiveness profiles among antipsychotics may be a key point to optimize treatment in patients suffering first episode of psychosis impact on long-term outcome. The aim this study is compare the clinical olanzapine, risperidone, haloperidol, aripiprazole, ziprasidone, and quetiapine at 3-year follow-up.From February 2001 January 2011, 2 phases prospective, randomized, open-label were undertaken. A total 376 first-episode drug-naïve randomly assigned olanzapine (n = 55),...
We present an empirically benchmarked framework for sex-specific normative modeling of brain morphometry that can inform about the biological and behavioral significance deviations from typical age-related neuroanatomical changes support future study designs. This was developed using regional morphometric data 37,407 healthy individuals (53% female; aged 3-90 years) following a comparative evaluation eight algorithms multiple covariate combinations pertaining to image acquisition quality,...
Background Understanding the evolution of negative symptoms in first-episode psychosis (FEP) requires long-term longitudinal study designs that capture progression this condition and associated brain changes. Aims To explore factors underlying their association with abnormal trajectories. Method We followed up 357 people FEP over a 10-year period. Factor analyses were conducted to symptom dimensionality. Latent growth mixture modelling (LGMM) was used identify latent classes. Analysis...
The aim of this study was to assess the effects a school intervention programme based on modern board games during hours basic executive functions and academic skills (reading maths). A total 522 (age in years = 8.83 ± 1.85 SD; % female 45.5) primary students were enrolled. We conducted cluster-randomised controlled trial, with one experimental group (playing class) control (regular classes) all grades from first sixth. Mixed model analysis applied. In pre-post comparisons, children showed...
Abstract While sex differences in schizophrenia have long been reported and discussed, long-term outcomes among first episode of psychosis (FEP) patients terms the efficacy Early Intervention Services (EIS) has an under-explored area. A total 209 FEP (95 females 114 males) were reassessed after a time window ranging from 8 to 16 years their contact with EIS program (PAFIP) that we will call 10-year PAFIP cohort. Multiple clinical, cognitive, functioning, premorbid, sociodemographic variables...
Abstract The COVID-19 pandemic can seize the opportunity to explore hypothesis of prenatal exposure viral infections increases risk for neurodevelopmental disorders. Advancing our knowledge in this regard would improve primary prevention mental disorders children. For pilot study, six-week-old infants born mothers exposed (n = 21) or unexposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were assessed Santander-Cantabria (Spain) using Neonatal Behavioral Assessment Scale...
Article AbstractObjective: To investigate the neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode schizophrenia-spectrum disorders.Method: This prospective, randomized, open-label study was conducted from February 2001 to 2005. Data for present investigation were obtained a large epidemiologic 3-year longitudinal intervention program psychosis (DSM-IV criteria) at outpatient clinic inpatient unit University Hospital Marques de Valdecilla, Santander,...