A5065013242- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Adolescent and Pediatric Healthcare
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Electrolyte and hormonal disorders
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- Electroconvulsive Therapy Studies
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Mental Health and Psychiatry
- Extracellular vesicles in disease
- HIV Research and Treatment
- Inflammasome and immune disorders
- Phosphodiesterase function and regulation
Karolinska Institutet
2016-2025
Stockholm Health Care Services
2020-2025
Lithuanian Sports University
2025
Karolinska University Hospital
2015-2024
Stockholm County Council
2020-2023
University of Pavia
2022
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
2022
Technical University of Denmark
2022
Merck (Germany)
2022
KTH Royal Institute of Technology
2022
Accumulating evidence indicates that schizophrenia is associated with brain immune activation. While a number of reports suggest increased cytokine levels in patients schizophrenia, many these studies have been limited by their focus on peripheral cytokines or confounded various antipsychotic treatments. Here, well-characterized all receiving olanzapine treatment, and healthy volunteers were analyzed regard to cerebrospinal fluid (CSF) cytokines. We correlated the CSF previously metabolites...
Abstract Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved neuroinflammation regulates glutamate neurotransmission. In the cerebrospinal fluid (CSF) of patients, levels inflammatory cytokines metabolite quinolinic acid (QUIN), an N -methyl- d -aspartate receptor agonist, are increased. enzyme amino-β-carboxymuconate-semialdehyde-decarboxylase (ACMSD) limits QUIN formation by competitive production...
Abstract Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but mechanisms these effects unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that infection initiate neuronal cell death cause loss post-synaptic termini. Despite limited neurotropism decelerating viral replication, observe threefold increase microglial engulfment postsynaptic termini after exposure. We define responses to...
Importance Cognitive impairment contributes significantly to clinical outcome and level of function in individuals with psychotic disorders. These impairments are present already at psychosis onset a group level; however, the question heterogeneity cognitive among patients has not been systematically investigated. Objective To provide an updated quantification before receive potentially confounding antipsychotic treatment, investigate variability compared healthy controls. Data Sources In...
Sellgren C, Landén M, Lichtenstein P, Hultman CM, Långström N. Validity of bipolar disorder hospital discharge diagnoses: file review and multiple register linkage in Sweden. Objective: Hospital registers (HDRs) are frequently used epidemiological research. However, the validity several important psychiatric diagnostic entities, including disorder, remains uncertain. Hence, we aimed to develop an optimal algorithm for register‐based identification DSM‐IV‐TR disorder. Method: We identified...
Engulfment of synapses and neural progenitor cells (NPCs) by microglia is critical for the development maintenance proper brain circuitry, has been implicated in neurodevelopmental as well neurodegenerative disease etiology. We have developed validated models these mechanisms reprogramming microglia-like from peripheral blood mononuclear cells, combining them with NPCs neurons derived induced pluripotent stem to create patient-specific cellular complement-dependent synaptic pruning...
Bipolar disorder (BD) is a common chronic psychiatric mainly characterized by episodes of mania, hypomania and depression. The associated with cognitive impairments structural brain abnormalities, such as lower cortical volumes in primarily frontal regions than healthy controls. Although bipolar types I (BDI) II (BDII) exhibit different symptoms severity, previous studies have focused on BDI. Furthermore, the most frequently investigated measure this population volume. aim our study was to...
Higher numbers of manic episodes in bipolar patients has, cross-sectional studies, been associated with less grey matter volume prefrontal brain areas. Longitudinal studies are needed to determine if set off progressive cortical changes, or the association is better explained by premorbid conditions that increase risk for mania. We followed disorder type 1 6 years. Structural magnetic resonance imaging scans were performed at baseline and follow-up. compared who had least one episode between...
Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels schizophrenia result from pathological shift kynurenine pathway toward enhanced formation, away other branch leading to quinolinic (QUIN). Here we investigate QUIN cerebrospinal fluid (CSF) patients with and healthy controls, relate those CSF metabolites same individuals. stable outpatients treated olanzapine (n = 22) controls 26) were...
Although evidence for mitochondrial dysfunction in the pathogenesis of bipolar disorder (BD) has been reported, precise biological basis remains unknown, hampering search novel biomarkers. In this study, we performed metabolomics cerebrospinal fluid (CSF) from male BD patients (n=54) and age-matched healthy controls (n=40). Subsequently, post-mortem brain analyses, genetic CSF samples rats treated with lithium or valproic acid were also performed. After multivariate logistic regression,...
Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we conducted a genome-wide association study based on CSF KYNA disorder found support for an with common variant within 1p21.3. After replication independent cohort, linked this genetic variant-associated reduced SNX7 expression-to positive psychotic symptoms executive function deficits A...
Neuroinflammation is increasingly recognized as contributing to the pathogenesis of depression. Key inflammatory markers well kynurenic acid (KYNA) and quinolinic (QUIN), both tryptophan metabolites, have been associated with depressive symptoms suicidality. The aim present study investigate peripheral concentration cytokines kynurenine metabolites in patients unipolar treatment-resistant depression before after electroconvulsive therapy (ECT), most effective treatment for Cytokines plasma...
Bipolar disorder (BD) is a severe and debilitating psychiatric disorder. However, the precise biological basis remains unknown, hampering search for novel biomarkers. We performed metabolomics analysis to discover peripheral biomarkers BD. quantified serum levels of 116 metabolites in mood-stabilized male BD patients (n = 54) age-matched healthy controls 39). After multivariate logistic regression, pyruvate, N-acetylglutamic acid, α-ketoglutarate, arginine were significantly higher than...
Bipolar disorder is associated with medical comorbidities that have been linked to systemic inflammatory mechanisms. There is, however, limited evidence supporting a role of neuroinflammation in bipolar disorder. Here we tested whether microglial activation and tissue remodelling processes are related by analyzing markers cerebrospinal fluid (CSF) serum from patients healthy controls.Serum was sampled euthymic controls, CSF large subset these individuals. The levels monocyte chemoattractant...
Schizophrenia is a neurodevelopmental disorder characterized by an excessive loss of synapses. Kynurenic acid (KYNA), neuroactive metabolite tryptophan along the kynurenine pathway, can induce schizophrenia-related phenotypes in rodents, and clinical studies have revealed elevated KYNA levels CNS individuals with schizophrenia. However, factors that cause schizophrenia, mechanisms which contributes to pathophysiology, remain largely elusive. The authors used patient-derived cellular modeling...
Olsson SK, Sellgren C, Engberg G, Landén M, Erhardt S. Cerebrospinal fluid kynurenic acid is associated with manic and psychotic features in patients bipolar I disorder. Bipolar Disord 2012: 14: 719–726. © 2012 The Authors. Journal compilation John Wiley & Sons A/S. Objectives: Kynurenic (KYNA), an end metabolite of tryptophan degradation, antagonizes glutamatergic cholinergic receptors the brain. Recently, we reported elevated levels cerebrospinal (CSF) KYNA male Here, investigate...
Objective Recent studies indicate that inflammation may play a role in the pathophysiology of suicidality. Interleukin‐8 ( IL ‐8) is chemokine addition to its function immune system also exert neuroprotective properties. The involvement this neuropsychiatric conditions incompletely known. Method We measured plasma and cerebrospinal fluid CSF ) ‐8, as well genotype frequency single nucleotide polymorphism (‐251A/T, rs4073) promoter region 8 gene, suicide attempters n = 206) healthy controls...
Abstract The ability of small secretory microvesicles known as exosomes to influence neuronal and glial function via their microRNA (miRNA) cargo has positioned them a novel effective method cell-to-cell communication. However, little is about the role exosome-secreted miRNAs in regulation glutamate receptor gene expression relevance for schizophrenia (SCZ) bipolar disorder (BD). Using mature miRNA profiling quantitative real-time PCR (qRT-PCR) orbitofrontal cortex (OFC) SCZ ( N = 29; 20...
Abstract Metabolites of the kynurenine pathway tryptophan degradation, in particular, N -Methyl- d -aspartic acid receptor antagonist kynurenic (KYNA), are increasingly recognized as primary pathophysiological promoters several psychiatric diseases. Studies analyzing central KYNA levels from subjects with psychotic disorders have reported increased levels. However, sample sizes limited and contrast many larger studies examining this compound blood patients commonly report a decrease. A major...