A5043516060- Neuroscience and Neuropharmacology Research
- Pain Management and Placebo Effect
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Neural dynamics and brain function
- Bipolar Disorder and Treatment
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Reading and Literacy Development
- Schizophrenia research and treatment
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Psychosomatic Disorders and Their Treatments
- Neonatal and fetal brain pathology
Karolinska Institutet
2016-2025
Karolinska University Hospital
2008-2022
University of Gothenburg
2016-2021
Dalhousie University
2021
Stanford University
2021
National Institute of Mental Health
1985-2015
United States Public Health Service
2015
KTH Royal Institute of Technology
2013
National Institutes of Health
2013
The University of Texas Southwestern Medical Center
2009
It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex (rACC) the brainstem are implicated in analgesia, suggesting a similar role for these structures analgesia. Using positron emission tomography, we confirmed associated with increased activity rACC. We also observed covariation between rACC during but not pain-only condition. These findings indicate related neural mechanism
Despite decades of research, the pathophysiology bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies inconsistent. To address this, we performed largest study to date cortical gray matter thickness and surface area measures magnetic resonance imaging scans 6503 individuals including 1837 unrelated adults BD 2582 healthy controls for group while also examining effects commonly prescribed...
This study was undertaken to explore whether the neural substrates demonstrated in brain imaging studies on experimentally induced pain are involved perception of chronic neuropathic pain. We investigated cerebral representation lateralised ongoing patients with painful mononeuropathy (PMN, i.e., distribution a nerve, neuralgia) positron emission tomography (PET), using regional blood flow (rCBF) as an index for neuronal activity. Eight (29-53 years) PMN lower extremity (4 right, 4 left)...
To explore neural correlates of cognitive decline in aging, we used longitudinal behavioral data to identify two groups older adults (n = 40) that differed with regard whether their performance on tests episodic memory remained stable or declined over a decade. Analysis structural and diffusion tensor imaging (DTI) revealed heterogeneous set differences associated decline. Manual tracing hippocampal volume showed significant reduction those declining as did DTI-measured fractional anisotropy...
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying sources of can help generate novel clinical hypotheses etiology assist in development biomarkers for indexing disease progression prognosis. Here we were interested case-control differences intracranial volume (ICV) each eight subcortical measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a...
It has previously been suggested that the activity in sensory regions of brain can be modulated by attentional mechanisms during parallel cognitive processing. To investigate whether such attention-related modulations are present processing pain, regional cerebral blood flow was measured using [(15)O]butanol and positron emission tomography conditions involving both pain demands. The painful stimulus consisted standard cold pressor test task a computerised perceptual maze test. activations...
While the importance of physical abilities and motor coordination is non-contested in sport, more focus has recently been turned toward cognitive processes important for different sports. However, this line studies often investigated sport-specific traits, while few have focused on general traits. We explored if measures executive functions can predict success a soccer player. The present study used standardized neuropsychological assessment tools assessing players' including on-line...
Over the years, many have viewed Fibromyalgia syndrome (FMS) as a so-called "functional disorder" and patients experienced concomitant lack of interest legitimacy from medical profession. The symptoms not been explained by peripheral mechanisms alone nor specific central nervous system mechanisms. In this study, we objectively evaluated cerebral response to individually calibrated pain provocations pain-free body region (thumbnail). study comprised 16 female FMS age-matched controls. Brain...
The dominant theories of human placebo effects rely on a notion that consciously perceptible cues, such as verbal information or distinct stimuli in classical conditioning, provide signals activate effects. However, growing evidence suggest behavior can be triggered by presented outside conscious awareness. Here, we performed two experiments which the responses to thermal pain were assessed. first experiment assessed whether conditioning paradigm, using clearly visible cues for high and low...
Conditioning procedures are used in many placebo studies because evidence suggests that conditioning-related responses usually more robust than those induced by verbal suggestions alone. However, it has not been shown whether there is a causal relation between the number of conditioning trials and resistance to extinction nocebo responses. Here we test effects either one or four sessions on modulation both non-painful painful stimuli delivered dorsum foot. Placebo manipulations were obtained...
Background: There is evidence for augmented processing of pain and impaired endogenous inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved FM pathology, there a need closer investigation modulation. present study, we compared functional connectivity descending inhibitory network age-matched patients healthy controls (HC). We performed magnetic resonance imaging (fMRI) 42 subjects; 14 28 (2 per HC), during randomly presented, subjectively calibrated...
Physical capacity and coordination cannot alone predict success in team sports such as soccer. Instead, more focus has been directed towards the importance of cognitive abilities, it suggested that executive functions (EF) are fundamentally important for However, going through a steep development from adolescence to adulthood. Moreover, complex EF involving manipulation information (higher level EF) develop later than simple those linked working memory (Core EF). The link between young...
Fibromyalgia (FM) is characterized by widespread pain and co-morbid symptoms such as fatigue depression. For FM, medical treatments alone appear insufficient. Recent meta-analyses point to the utility of cognitive behaviour therapy (CBT), but effects are moderate. Within continuous development CBT, empirical support for acceptance commitment (ACT) has increased rapidly. ACT focuses on improving functioning increasing patient's ability act in accordance with personal values also presence...
Interventions based on Cognitive Behavioral Therapy (CBT) are widely used to treat chronic pain, but the brain mechanisms responsible for these treatment effects poorly understood. The aim of this study was validate relevance cortical control theory in response an exposure-based form CBT, Acceptance and Commitment Therapy, patients with pain. Forty-three female diagnosed fibromyalgia syndrome were enrolled a randomized, 12-week, waiting-list controlled clinical trial (CBT n=25; controls...
Abstract Neuronal necrosis in the brain resulting from status epilepticus of 15 to 120 minutes duration ventilated and well‐oxygenated rats was assessed. Seizures were induced by inhalation convulsant gas flurothyl, terminated withdrawal flurothyl a single injection thiopental. The animals allowed recover for one week, neuronal damage assessed cell counts following subserial sectioning microscopical examination sections. Infarction pars reticulata substantia nigra occurred 5 6 with seizure...
Cognitive studies show that both younger and older adults can increase their memory performance after training in using a visuospatial mnemonic, although age-related deficits tend to be magnified rather than reduced training. Little is known about the changes functional brain activity accompany training-induced enhancement, whether are associated with size of training-related gains. Here, we demonstrate increased during encoding occipito-parietal frontal regions learning mnemonic. Older did...
The study was conducted to investigate which areas of the brain respond a painful encounter minor dermal injury (a model clinical pain) elicited by intracutaneous injection minute amount ethanol. Four healthy volunteers (27-46 years) were subjected positron emission tomographic (PET) investigation regional cerebral blood flow (rCBF), using [15O]butanol as tracer. ethanol (20 microliters, 70%) and saline 0.9%) injected intracutaneously 3 times in single-blinded, semi-randomised manner for...
1. We used functional positron emission tomography (PET), measuring regional cerebral blood flow (rCBF) as an index of neuronal activity, to investigate the central processing itch in 10 healthy volunteers subjected intracutaneous injections histamine. 2. The study has unraveled a representation that depicts motor intention urge scratch contingent on perception unpleasant itch. coactivation anterior cingulate cortex (ACC), supplementary area (SMA), premotor (PM), and inferior parietal lobule...
Abstract: Dopaminergic innervation of the caudate nucleus in adult rats can be partially restored by grafting embryonic substantia nigra into overlying parietal cortex with concomitant compensation certain behavioral abnormalities. In this study function such grafts was investigated neurochemically quantification transmitter metabolism and glucose utilization reinnervated target. Rats unilateral 6‐hydroxydopamine lesions nigrostriatal bundle received a single graft to dorsal caudateputamen...