A5019168728- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Memory Processes and Influences
- Neurobiology of Language and Bilingualism
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Reading and Literacy Development
- Cognitive Functions and Memory
- Cognitive and developmental aspects of mathematical skills
- Microfluidic and Capillary Electrophoresis Applications
- Sleep and related disorders
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Face Recognition and Perception
- Gut microbiota and health
- Cognitive Abilities and Testing
- Mental Health Research Topics
- Growth Hormone and Insulin-like Growth Factors
- Microfluidic and Bio-sensing Technologies
- Neural dynamics and brain function
- Language Development and Disorders
- Neuroscience, Education and Cognitive Function
Stockholm University
2016-2025
Karolinska Institutet
2016-2025
Örebro University
2019-2025
Karolinska University Hospital
2024
Swedish Defence Research Agency
1992-2020
KTH Royal Institute of Technology
2020
Umeå University
2000-2014
Svenska Örtmedicinska Institute
2012-2013
Imagerie et Cerveau
2013
Centre for Biomedical Engineering and Physics
2013
To explore neural correlates of cognitive decline in aging, we used longitudinal behavioral data to identify two groups older adults (n = 40) that differed with regard whether their performance on tests episodic memory remained stable or declined over a decade. Analysis structural and diffusion tensor imaging (DTI) revealed heterogeneous set differences associated decline. Manual tracing hippocampal volume showed significant reduction those declining as did DTI-measured fractional anisotropy...
The network of regions shown by functional imaging studies to be deactivated experimental tasks relative nominally more passive baselines (task < baseline) may reflect processes engaged during the resting state or "default mode." Deactivation result when attention and resources are diverted from default-mode toward task processes. Aging is associated with altered patterns deactivation which related declining resources, difficulties resource allocation, both. These possibilities predict that...
Cross-sectional estimates of age-related changes in brain structure and function were compared with 6-y longitudinal estimates. The results indicated increased sensitivity the approach as well qualitative differences. Critically, cross-sectional analyses suggestive frontal overrecruitment, whereas revealed underrecruitment advancing age. observation overrecruitment reflected a select elderly sample. However, when followed over time, this sample showed reduced recruitment. These findings...
By integrating behavioral measures and imaging data, previous investigations have explored the relationship between biological markers of aging cognitive functions. Evidence from functional structural neuroimaging has revealed that hippocampal volume activation patterns in medial temporal lobe (MTL) may predict performance old age. Most past demonstrations age-related differences brain structure–function were based on cross-sectional comparisons. Here, 6-year intraindividual change magnetic...
Previous research has shown that polymorphisms of apolipoprotein E (APOE) represent genetic risk factors for dementia and cognitive impairment in the elderly. The neural mechanisms by which these variations influence behavioral performance or clinical severity are not well understood.The authors used diffusion tensor imaging to investigate ultrastructural properties brain white matter detect pathologic processes modify tissue integrity. Sixty participants were included study 30 homozygous...
Some elderly appear to resist age-related decline in cognitive functions, but the neural correlates of successful aging are not well known. Here, older human participants from a longitudinal study were classified as or average relative mean attrition-corrected development across 15–20 years population-based sample ( n = 1561). Fifty-one and 51 age-matched (mean age: 68.8 years) underwent functional magnetic resonance imaging while performing an episodic memory face–name paired-associates...
Abstract Large-scale networks of brain regions are believed to mediate cognitive processes, including episodic memory. Analyses regional differences in activity, measured by functional neuroimaging, have begun identify putative components these networks. To more fully characterize neurocognitive networks, however, it is necessary use analytical methods that quantify neural network interactions. Here, we used positron emission tomography (PET) measure activity during initial encoding and...
Functional brain-imaging data document overlapping sites of activation in prefrontal cortex across memory tasks, suggesting that these tasks may share common executive components. We leveraged this evidence to develop a training regimen and set transfer examine the trainability putative executive-control process: interference resolution. Eight days on high-interference versions three different working increased efficiency with which proactive was resolved those particular tasks. Moreover, an...
The dorsolateral pFC (DLPFC) is a key region for working memory. It has been proposed that the DLPFC dynamically recruited depending on task demands. By this view, high recruitment low-demanding tasks along with weak upregulation at higher demands reflects low efficiency. Here, fMRI BOLD signal during memory maintenance and manipulation was examined in relation to aging catechol-O-methyltransferase (COMT) Val(158)Met status large representative sample (n = 287). efficiency hypothesis...
Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and 2 diabetes. Here we studied some phenotypic features of a well-established animal model diabetes, leptin receptor-deficient db − /db mouse, also effect long-term (6 mo) treatment with coenzyme Q10 (CoQ10), an endogenous antioxidant. mice at 8 mo age exhibited loss sensation, hypoalgesia (an increase mechanical threshold), decreases hyperalgesia, cold allodynia, sciatic nerve conduction velocity. All these...
Abstract Executive control coordinates, prioritizes, and selects task-relevant representations under conditions of conflict. Behavioral evidence has documented that executive resources are separable, finite, can be temporarily depleted; however, the neural basis for such resource limits largely unknown. Here, we investigate correlates underlying fatigue or depletion interference control, an process hypothesized to mediate competition among candidate memory representations. Using a pre/post...
Probiotics can alter brain function via the gut-brain axis. We investigated effect of a probiotic mixture containing Bifidobacterium longum, Lactobacillus helveticus and Lactiplantibacillus plantarum. In randomized, placebo-controlled, double-blinded crossover design, 22 healthy subjects (6 m/16 f; 24.2 ± 3.4 years) underwent four-week intervention periods with probiotics placebo, separated by washout period. Voxel-based morphometry indicated that affected gray matter volume cluster covering...