A5041047931- Birth, Development, and Health
- Dementia and Cognitive Impairment Research
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cholesterol and Lipid Metabolism
- Gestational Diabetes Research and Management
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Sleep and related disorders
- Pharmaceutical studies and practices
- Biochemical Analysis and Sensing Techniques
- Pregnancy and preeclampsia studies
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Hippo pathway signaling and YAP/TAZ
- Forensic Anthropology and Bioarchaeology Studies
- Forensic and Genetic Research
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Cancer-related gene regulation
- Olfactory and Sensory Function Studies
Shandong Provincial Hospital
2017-2025
Shandong First Medical University
2020-2025
Yinchuan First People's Hospital
2024
Ningxia Medical University
2016-2024
Children's Hospital of Chongqing Medical University
2015-2024
Chongqing Medical University
2015-2024
Shandong University
2017-2024
China International Science and Technology Cooperation
2017-2024
Nanjing Medical University
2007-2024
Huaian First People’s Hospital
2024
Abstract Exosomes are nanosized membrane vesicles released from cells after fusion of multivesicular bodies (MVBs) with the plasma (PM) and play important roles in intercellular communication numerous biological processes. However, molecular mechanisms regulating exosome secretion remain poorly understood. Here we identify KIBRA as an adaptor-like protein that stabilizes Rab27a, which turn controls both vitro vivo. Knockdown or overexpression neuronal podocyte cell lines leads to a decrease...
By using specific anti-ACAT-1 antibodies in immunodepletion studies, we previously found that ACAT-1, a 50-kDa protein, plays major catalytic role the adult human liver, adrenal glands, macrophages, and kidneys but not intestine. Acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity intestine may be largely derived from different ACAT protein. To test this hypothesis, produced polyclonal anti-ACAT-2 quantitatively immunodepleted ACAT-2, 46-kDa protein expressed Chinese hamster ovary...
To investigate the prevalence and associated factors of poor sleep quality among community-dwelling elderly population in a rural area Northern China.We conducted cross-sectional survey August-December 2014 recruited 2195 participants who were aged 65 years or older living Yanlou Town Yanggu County western Shandong Province, China. Data on demographics, health-related behaviors, clinical conditions collected through structured interviews. The Pittsburgh Sleep Quality Index (PSQI) was used to...
Background and Purpose Excessive fructose consumption is a risk factor for liver fibrosis. Pterostilbene protects against Here, we investigated the potential role mechanisms underlying hepatocyte epithelial‐mesenchymal transition (EMT) in fructose‐induced fibrosis protection by pterostilbene. Experimental Approach Characteristic features of 10% fructose‐fed rats EMT 5 mM fructose‐exposed BRL‐3A cells with or without pterostilbene change miR‐34a/Sirt1/p53 transforming growth factor‐β1...
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial mutation with simultaneous or consecutive binocular painless loss of vision and central visual field (VF) defects.1Lam B.L. Feuer W.J. Schiffman J.C. et al.Trial end points natural history in patients G11778A Leber neuropathy: preparation for gene therapy clinical trial.JAMA Ophthalmol. 2014; 132: 428-436Crossref PubMed Scopus (77) Google Scholar In 2008, we initiated recombinant adeno-associated...
Individuals deficient in vitamin D are more likely to have higher circulating cholesterol levels and cardiovascular diseases. However, the underlying mechanisms still unclear.A cross-sectional survey, animal study, vitro experiments were conducted investigate effect of deficiency on endogenous metabolism. We demonstrated that was positively associated with an increase total serum low-density lipoprotein northern Chinese individuals. The deficiency-induced concentration mainly due enhanced...
Obesity is considered to be accompanied by a chronic low-grade inflammatory state that contributes the occurrence of many diseases. Our previous study has demonstrated histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women. However, vivo potential mechanisms are not known. The present was conducted investigate underlying effects on high-fat diet (HFD)-induced female rat model. An model established Sprague–Dawley rats HFD feeding for 8 weeks...
Fructose consumption can induce insulin resistance and metabolic syndrome, which are associated with glomerular podocyte dysfunction proteinuria. This study investigated whether fructose caused signaling impairment in injury, curcumin reduced these disturbances.Rats were fed 10% for 6 weeks then orally cotreated next weeks. Metabolic microRNA expression, evaluated. Curcumin significantly alleviated fructose-induced injury proteinuria, miR-206 low-expression, protein tyrosine phosphatase 1B...
Acyl-CoA:cholesterol acyltransferase (ACAT) is a membrane-bound enzyme that produces cholesteryl esters intracellularly. Two ACAT genes (ACAT1 and ACAT2) have been identified. The expression of ACAT1 ubiquitous, whereas ACAT2 tissue restricted. Previous research indicates may contain seven transmembrane domains (TMDs). To study topology, we inserted two different antigenic tags (hemagglutinin, monoclonal antibody Mab1) at various hydrophilic regions flanking each its predicted TMDs,...
Acyl-CoA:cholesterol acyltransferase (ACAT) plays important roles in cellular cholesterol homeostasis and is involved atherosclerosis. ACAT-1 protein located mainly the ER. The hydropathy plot suggests that contains multiple transmembrane segments. We inserted either hemagglutinin tag or HisT7 at various hydrophilic regions within human used immunofluorescence microscopy to determine topography of tagged proteins expressed mutant Chinese hamster ovary cells lacking endogenous ACAT. All are...
// Bing He 1, * , Ting Li Lei Guan Fang-E Liu 2 Xue-Mei Chen 1 Jing Zhao Song Lin Zhi-Zhen Hu-Qin Zhang The Key Laboratory of Biomedical Information Engineering Ministry Education, School Life Science and Technology, Xi’an Jiaotong University, 710049, P.R. China Center Basic Medicine Teaching Experiments, Medicine, Fourth Military University (FMMU), 710032, These authors contributed equally to this work Correspondence to: Zhang, e-mail: huqzhang@mail.xjtu.edu.cn Keywords: CTNNA3,...
Fructose induces insulin resistance with kidney inflammation and injury. MicroRNAs are emerged as key regulators of signaling. Morin has insulin-mimetic effect the improvement This study investigated protective mechanisms morin against fructose-induced injury, particular focus on miR-330 expression change, inflammatory response, signaling impairment.miR-330, sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/S1P receptor (S1PR)1/3 signaling, nuclear factor-κB (NF-κB)/NOD-like family,...
This study aimed to determine how the rat placenta and fetus respond maternal high-fat (HF) diet during gestation identify possible mechanisms.Pregnant Sprague-Dawley rats were fed with standard chow (13.5% fat) or HF (60% gestation. Placentas collected on day 21.HF dams had greater fat mass, higher plasma leptin, lower adiponectin, impaired glucose tolerance pregnancy. The placental labyrinth thickness was reduced in both male female fetuses of dams. In placentas, transporter 3 gene...