A5039072550- Metal-Catalyzed Oxygenation Mechanisms
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Microbial metabolism and enzyme function
- Forensic Anthropology and Bioarchaeology Studies
- Circadian rhythm and melatonin
- Forensic and Genetic Research
- Metabolism and Genetic Disorders
- Obesity, Physical Activity, Diet
- RNA Research and Splicing
- Heme Oxygenase-1 and Carbon Monoxide
- Breastfeeding Practices and Influences
- Hemoglobin structure and function
- Peroxisome Proliferator-Activated Receptors
- Redox biology and oxidative stress
- Magnolia and Illicium research
- Vasculitis and related conditions
- Gut microbiota and health
- Atherosclerosis and Cardiovascular Diseases
- Stress Responses and Cortisol
- Public Health and Nutrition
- Chromatography in Natural Products
Shandong Provincial QianFoShan Hospital
2022
Shandong First Medical University
2022
Xi'an Peihua University
2017-2020
University of Chicago
2014-2018
University of Pennsylvania
2018
Howard Hughes Medical Institute
2016-2018
The University of Texas at San Antonio
2017
Georgia State University
2009-2017
Xi'an Jiaotong University
2017
Air Force Medical University
2007-2016
Pirin is a nuclear nonheme Fe protein of unknown function present in all human tissues. Here we describe that pirin may act as redox sensor for the factor κB (NF-κB) transcription factor, critical mediator intracellular signaling has been linked to cellular responses proinflammatory signals and controls expression vast array genes involved immune stress responses. Pirin’s regulatory effect was tested with several metals at different oxidations states, our spectroscopic results show only...
[VO(Sal-L-tryp)(H2O)] 1 (where sal-L-tryp = N-salicylidene-L-tryptophanate) was used as a precursor to produce the novel complexes, [VO(Sal-L-tryp)(MeATSC)].1.5C2H5OH 2 MeATSC 9-Anthraldehyde-N(4)-methylthiosemicarbazone), [VO(Sal-L-tryp)(N-Ethhymethohcarbthio)].H2O 3 N-Ethhymethohcarbthio (E)-N-ethyl-2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide), and [VO(Sal-L-tryp)(acetylethTSC)].C2H5OH 4 acetylethTSC (E)-N-ethyl-2-(1-(thiazol-2-yl)ethylidene)hydrazinecarbothioamide), by...
ALKBH5, a member of AlkB family proteins, has been reported as mammalian N 6 ‐methyladenosine (m A) RNA demethylase. Here we report the crystal structure zebrafish ALKBH5 (fALKBH5) with resolution 1.65 Å. Structural superimposition shows that fALKBH5 is comprised conserved jelly‐roll motif. However, it possesses loop interferes potential binding duplex nucleic acid substrate, suggesting an important role in substrate selection. In addition, several active site residues are different between...
Overweight and obesity are major public health crises among children adolescents contribute to a significant economic burden. We aimed investigate the relationship between breastfeeding duration overweight in Qingdao, China 2017.This study conducted survey with 10,753 students (5370 boys 5383 girls) aged 6 16 years from Shibei District of 2017. Anthropometric measurements were taken by well-trained personnel self-completed questionnaires used collect data students. A variety statistical...
Despite the importance of tryptophan (Trp) radicals in biology, very few have been trapped and characterized a physiologically meaningful context. Here we demonstrate that diheme enzyme MauG uses Trp radical chemistry to catalyze formation Trp-derived tryptophylquinone cofactor on its substrate protein, premethylamine dehydrogenase. The unusual six-electron oxidation results occurs three discrete two-electron catalytic steps. exact order these steps processive biosynthetic reaction is...
// Bing He 1, * , Ting Li Lei Guan Fang-E Liu 2 Xue-Mei Chen 1 Jing Zhao Song Lin Zhi-Zhen Hu-Qin Zhang The Key Laboratory of Biomedical Information Engineering Ministry Education, School Life Science and Technology, Xi’an Jiaotong University, 710049, P.R. China Center Basic Medicine Teaching Experiments, Medicine, Fourth Military University (FMMU), 710032, These authors contributed equally to this work Correspondence to: Zhang, e-mail: huqzhang@mail.xjtu.edu.cn Keywords: CTNNA3,...
There are increasing evidences for gastrointestinal motility disorder (GIMD) and gastric stress ulcer induced by noise stress. The present study was to investigate the reversed effect of melatonin on GIMD potential mechanism.Noise rats, (15 mg/kg) administered rats intraperitoneal injection. Differences were assessed in residual rate (GRR), small intestine propulsion (SPR), Guth injury score, cortisol, hormones (calcitonin-gene-related peptide motilin) oxidative markers (superoxide dismutase...
ABSTRACT Human α‐amino‐β‐carboxymuconate‐ε‐semialdehyde decarboxylase determines the fate of tryptophan metabolites in kynurenine pathway by controlling quinolinate levels for de novo nicotinamide adenine dinucleotide biosynthesis. The unstable nature its substrate has made gaining insight into reaction mechanism difficult. Our electron paramagnetic resonance (EPR) spectroscopic study on Cu‐substituted human enzyme suggests that native does not directly ligate to metal ion. Substrate binding...
Abstract Aldehydes are ubiquitous intermediates in metabolic pathways and their innate reactivity can often make them quite unstable. There several aldehydic the pathway for tryptophan degradation that decay into neuroactive compounds have been associated with numerous neurological diseases. An enzyme of this pathway, 2-aminomuconate-6-semialdehyde dehydrogenase, is responsible ‘disarming’ final intermediate. Here we show crystal structures a bacterial analogue five catalytically relevant...
Patients with prehypertension are more likely to progress manifest hypertension than those optimal or normal blood pressure. However, the mechanisms underlying development from still remain largely elusive and drugs for antihypertensive treatment in absent. Here we determined effects of magnolol (MAG) on pressure aortic vasodilatation insulin, investigated mechanisms. Four-week-old male spontaneous hypertensive rats (SHR) age-matched normotensive Wistar-Kyoto (WKY) control were used. Our...
MEIS2 has been identified as one of the key transcription factors in gene regulatory network development and pathogenesis human cancers. Our study aims to identify mechanisms hepatocellular carcinoma (HCC), which could be targeted develop new therapeutic strategies.The variation levels were assayed a cohort HCC patients. The proliferation, clone-formation, migration, invasion abilities cells measured analyze effects MEIS2C MEIS2D (MEIS2C/D) knockdown with small hairpin RNAs vitro vivo....
MauG is a diheme enzyme that oxidizes two protein-bound tryptophan residues to generate catalytic tryptophylquinone cofactor within methylamine dehydrogenase. Upon the two-electron oxidation of bis-ferric MauG, c-type hemes exist as spin-uncoupled bis-Fe(IV) species with only one binding oxygen, which chemically equivalent single ferryl heme plus pi porphyrin cation radical ( Li , X. et al. 2008 ) Proc. Natl. Acad. Sci. U.S.A. 105 8597 - 8600 ). The EPR spectrum nitrosyl complex fully...
Apocynum venetum, a Chinese medicinal herb, is reported to be neuroprotective. However, whether venetum leaf extract (AVLE) protects against ischemic myocardium remains elusive. Our present study was aimed observe the effects of AVLE preconditioning on myocardial ischemia/reperfusion (MI/R) injury and investigate possible mechanisms. Rats were treated with (500 mg/kg/d, o.g.) or distilled water once daily for one week. Afterward, all animals subjected 30 min ischemia followed by 4 h...