A5006953773- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Protein Interaction Studies and Fluorescence Analysis
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- Organometallic Compounds Synthesis and Characterization
- Drug Transport and Resistance Mechanisms
- Crystallography and molecular interactions
- Crystal structures of chemical compounds
- Inorganic and Organometallic Chemistry
- DNA and Nucleic Acid Chemistry
- Computational Drug Discovery Methods
- Electrochemical Analysis and Applications
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Chemical Reaction Mechanisms
- Ferrocene Chemistry and Applications
- Advanced oxidation water treatment
- Coordination Chemistry and Organometallics
- Protein Structure and Dynamics
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
Duke Kunshan University
2023
University of Virginia's College at Wise
2017-2020
University of Arkansas Community College at Batesville
2009-2016
Lyon College
2005-2016
In-Q-Tel
2011
University of the West Indies System
1993-2006
Texas A&M University
1998-2000
A novel microwave-assisted synthetic method has been used to synthesise a series of mixed ligand ruthenium(II) compounds containing diimine as well bidentate thiosemicarbazone ligands. The contain the 1,10-phenanthroline (phen) or 2,2′-bipyridine (bpy) and is derived from 9-anthraldehyde. Based on elemental analyses spectroscopic data, are best formulated [(phen)2Ru(thiosemicarbazone)](PF6)2 where = 9-anthraldehydethiosemicarbazone, 9-anthraldehyde-N(4)-methylthiosemicarbazone,...
Abstract The present study investigates the use of algorithm selection for automatically choosing an any given protein–ligand docking task. In drug discovery and design process, conceptualizing binding is a major problem. Targeting this problem through computational methods beneficial in order to substantially reduce resource time requirements overall development process. One way addressing model it as search optimization There have been variety algorithmic solutions respect. However, there...
[VO(Sal-L-tryp)(H2O)] 1 (where sal-L-tryp = N-salicylidene-L-tryptophanate) was used as a precursor to produce the novel complexes, [VO(Sal-L-tryp)(MeATSC)].1.5C2H5OH 2 MeATSC 9-Anthraldehyde-N(4)-methylthiosemicarbazone), [VO(Sal-L-tryp)(N-Ethhymethohcarbthio)].H2O 3 N-Ethhymethohcarbthio (E)-N-ethyl-2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide), and [VO(Sal-L-tryp)(acetylethTSC)].C2H5OH 4 acetylethTSC (E)-N-ethyl-2-(1-(thiazol-2-yl)ethylidene)hydrazinecarbothioamide), by...
We have synthesized and evaluated the biological properties of a compound type [η6-p-cymene)Ru(EtATSC)Cl]Cl (1) where EtATSC = 2-anthracen-9-ylmethylene-N-ethylhydrazinecarbothioamide, thiosemicarbazone. The complex has been characterized by elemental analysis, spectroscopically (NMR, UV-Vis, IR) structurally XRD. in vitro anticancer activity 1 against two human colon cancer cell lines. IC50 value for HCT-116 was 224 ± 7 μM 205 5 Caco-2 line. proficiency as an antibacterial agent also six...
The reaction of [(eta(6)-p-cymene)Ru(ATSC)Cl]PF(6) (ATSC = 9-anthraldehyde thiosemicarbazone) with human serum albumin was investigated at different temperatures using fluorescence and infrared spectrophotometry. binding constant, K, for the determined a number methods. Using modified Stern-Volmer equation, K to be 9.09 x 10(4), 12.1 13.1 10(4) M(-1) 293 298 308 respectively. A thermodynamic analysis showed that is spontaneous DeltaG being negative. enthalpy DeltaH 16.5kJ mol(-1) entropy...
We have used a novel microwave‐assisted method to synthesize pair of half‐sandwich ruthenium–arene–thiosemicarbazone complexes the type [(η 6 ‐C H Ru(TSC)Cl]PF . The thiosemicarbazone (TSC) ligands are 2‐(anthracen‐9‐ylmethylene)hydrazinecarbothioamide and 2‐(anthracen‐9‐ylmethylene)‐ N ‐ethylhydrazinecarbothioamide derived from 9‐anthraldehyde. moderately strong binders DNA, with binding constants 10 4 m −1 They also human serum albumin, having order 5 show some in vitro anticancer activity...
A novel thiosemicarbazone from 2-acetonaphthone (represented as acnTSC) has been synthesized and its basic coordination chemistry with zinc(II), cobalt(II), copper(II) explored. The complexes were characterized by elemental analysis various spectroscopic techniques are best formulated [M(acnTSC) 2 Cl ] the metal likely in an octahedral environment. anticancer activity of was determined against a panel human colon cancer cells (HCT-116 Caco-2). compounds bind to DNA via intercalative mode...
A series of half-sandwich ruthenium complexes, two containing an arene face-cap and the other a thiacrown ether were synthesized to investigate necessity for anticancer activity in this class compounds.The complexes are formulated as [(η 6 -p-cymene)Ru(dmabTSC)Cl]PF , -benzene) Ru(dmabTSC)Cl]PF (arene complexes), [([9]aneS 3 (dmabTSC)Cl]PF (dmabTSC = dimethylaminobenzaldehye thiosemicarbazone).It was observed that none showed good vitro against HCT-116 Caco-2 (colon adenocarcinoma) cells.All...
Abstract Ruthenium organometallic compounds represent an attractive avenue in developing alternatives to platinum-based chemotherapeutic agents. While evidence has been presented indicating ruthenium-based interact with isolated DNA vitro, it is unclear what effect these exert cells. Moreover, the antibiotic efficacy of polynuclear ruthenium remains uncertain. In present study, we report that exposure induces recruitment damaged sensing protein Xeroderma pigmentosum Group C into...
The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) has been recognized as a promising anticancer drug target because it is overexpressed in various types of cancer and associated with poor prognosis. In the present study, we aimed to discover potential inhibitors from Enamine HTS library which consists over one million compounds. A consensus docking-based virtual screening workflow was adopted two hits, E96 E41, were identified for being ranked top 5 all docking...
The oxidation of L-ascorbic acid by the iron(III) dimeric complex [Fe2(CN)10]4– in acidic aqueous solution at an ionic strength 1.0 mol dm–3(NaClO4) has been studied stopped-flow spectrophotometry. overall reaction, which entails reduction both centres followed aquation resulting formation 2 [Fe(CN)5(OH2)]3–, takes place three stages. first is a one-electron to form mixed-valence iron(III, II) dimer second other centre iron(II) dimer. third stage occurs with very small absorbance change was...