A5055758842- Plant-Derived Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Essential Oils and Antimicrobial Activity
- Natural Antidiabetic Agents Studies
- Plant biochemistry and biosynthesis
- Psidium guajava Extracts and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Pomegranate: compositions and health benefits
- Phytochemistry and Biological Activities
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Medicinal Plants and Neuroprotection
- Gut microbiota and health
- Tryptophan and brain disorders
- Fungal Biology and Applications
- Phytochemical compounds biological activities
- Natural Compound Pharmacology Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Sesquiterpenes and Asteraceae Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
Zhejiang Ocean University
2023-2025
Zhejiang University
2023-2025
Northeastern University
2016-2025
Guangzhou Eighth People's Hospital
2020-2024
Guangzhou Medical University
2020-2024
Second Affiliated Hospital of Dalian Medical University
2017-2024
City University of Macau
2022-2024
Dalian Medical University
2017-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Sanya University
2023-2024
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in pharyngeal swab, blood, and anal swab detected by real-time PCR clinical lab. Unexpectedly, 2109-nCoV RNA was readily blood (6 of 57 patients) swabs (11 28 patients). Importantly, all 6 patients with detectable viral cohort progressed to severe symptom stage, indicating a strong correlation serum disease severity (p-value = 0.0001). Meanwhile, 8 11 annal virus-positive stage....
Dietary phytochemicals are known to exhibit a variety of anticarcinogenic properties. This study investigated the chemopreventive activity blueberry extract in triple-negative breast cancer cell lines vitro and vivo. Blueberry decreased proliferation HCC38, HCC1937, MDA-MB-231 cells with no effect on nontumorigenic MCF-10A line. Decreased metastatic potential by was shown through inhibition motility using wound-healing assays migration polyethylene terephthalate membrane. treatment matrix...
Twenty-three phenolic compounds were isolated from a butanol extract of Canadian maple syrup (MS-BuOH) using chromatographic methods. The identified their nuclear magnetic resonance and mass spectral data as 7 lignans [lyoniresinol (1), secoisolariciresinol (2), dehydroconiferyl alcohol (3), 5′-methoxy-dehydroconiferyl (4), erythro-guaiacylglycerol-β-O-4′-coniferyl (5), erythro-guaiacylglycerol-β-O-4′-dihydroconiferyl (6),...
Recent data suggest that ellagitannins (ETs), a class of hydrolyzable tannins found in some fruits and nuts, may have beneficial effects against colon cancer. In the stomach gut, ETs hydrolyze to release ellagic acid (EA) are converted by gut microbiota urolithin A (UA; 3,8-dihydroxy-6H-dibenzopyran-6-one) type metabolites, which persist through enterohepatic circulation. However, little is known about mechanisms action either native compounds or their metabolites on carcinogenesis....
The ripe purple berries of the native Indian plant Eugenia jambolana Lam., known as Jamun, are popularly consumed and available in United States Florida Hawaii. Despite growing body data on chemopreventive potential edible berry extracts, there is paucity such for Jamun fruit. Therefore our laboratory initiated current study with following objectives: (1) to prepare a standardized fruit extract (JFE) biological studies (2) investigate antiproliferative pro-apoptotic effects JFE estrogen...
Emerging data suggest that urolithins, gut microbiota metabolites of ellagitannins, contribute toward multiple health benefits attributed to ellagitannin-rich foods, including walnuts, red raspberry, strawberry, and pomegranate. However, there is limited on whether the potential neuroprotective effects these foods are mediated by urolithins. Herein, we evaluated mechanisms antineuroinflammatory urolithins (urolithins A, B, C; 8-methyl-O-urolithin A; 8,9-dimethyl-O-urolithin C) in BV2 murine...
Chronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators neuroinflammation. In addition to providing energy cells, mitochondria also participate immunoinflammatory response disorders including Alzheimer's disease, Parkinson's multiple sclerosis epilepsy, by regulating processes such cell death inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, dynamics...
Maple syrup is made by boiling the sap collected from certain maple ( Acer ) species. During this process, phytochemicals naturally present in tree are concentrated syrup. Twenty-three a butanol extract of Canadian (MS-BuOH) had previously been reported; paper reports isolation and identification 30 additional compounds (1-30) its ethyl acetate (MS-EtOAc) not reported MS-BuOH. Of these, 4 new (1-3, 18) 20 (4-7, 10-12, 14-17, 19, 20, 22-24, 26, 28-30) being for first time. The include 3...
Plants of the Carex genus (Family: Cyperaceae) have attracted recent attention as potential food additives because they contain high levels bioactive polyphenols commonly found in plant foods. Seven compounds, which included two resveratrol oligomers and five flavonoids, were isolated from seeds folliculata L. (northern long sedge), a forage prevalent northern United States. The compounds identified by 1H 13C nuclear magnetic resonance mass spectrometry data. pallidol (1), dimer reported to...
A novel microwave-assisted synthetic method has been used to synthesise a series of mixed ligand ruthenium(II) compounds containing diimine as well bidentate thiosemicarbazone ligands. The contain the 1,10-phenanthroline (phen) or 2,2′-bipyridine (bpy) and is derived from 9-anthraldehyde. Based on elemental analyses spectroscopic data, are best formulated [(phen)2Ru(thiosemicarbazone)](PF6)2 where = 9-anthraldehydethiosemicarbazone, 9-anthraldehyde-N(4)-methylthiosemicarbazone,...
The antiproliferative effects of Canadian maple syrup (grades C and D) extracts fifty-one purified phenolic constituents were evaluated against human tumourigenic (HT-29, HCT-116, CaCo-2) non-tumourigenic (CCD-18Co) colon cells. Overall, ethyl acetate (MS-EtOAc), butanol (MS-BuOH), methanol (MS-MeOH) more active the versus At equivalent levels, activities grade D > syrup, MS-BuOH MS-MeOH MS-EtOAc. Among isolates, gallic acid, catechaldehyde, syringaldehyde, catechol most their higher levels...
We evaluated whether fruit selection by autumn-migrating birds at an important stopover site in southern New England was related to water-soluble antioxidant content of fruits. measured total anthocyanins, phenolics, and capacity fruits from common native non-native plant species this estimates free-living birds. Birds selected certain over others, with arrowwood (Viburnum recognitum, V. dentatum) consumed the highest rate, followed Virginia creeper (Parthenocissus quinquefolia) much lower...
The red raspberry ( Rubus idaeus ) fruit contains bioactive polyphenols including anthocyanins and ellagitannins with reported anti-inflammatory properties. This study sought to investigate the cartilage-protecting effects of a polyphenolic-enriched extract (RRE; standardized total polyphenol, anthocyanin, ellagitannin contents) using (1) an in vitro bovine nasal explant cell culture model (2) vivo adjuvant-induced arthritis rat model. RRE contained 20% (as gallic acid equivalents), 5%...
UDP-glucuronosyltransferases (Ugt) catalyze phase II conjugation reactions with glucuronic acid, which enhances chemical polarity and the elimination from body. Few studies have addressed whether Ugt expression activity are affected by liver disease, such as steatosis. The purpose of this study was to determine steatosis induced obesity or fasting could affect mRNA activity. Male C57BL/6J Lep<i><sup>ob/ob</sup></i> (<i>ob/ob</i>) mice were fed ad libitum food withheld for 24 h. In steatotic...
Phenolic‐enriched extracts of maple sap and syrup, obtained from the sugar red species ( Acer saccharum Marsh, A. rubrum L., respectively), are reported to show anticancer effects. Despite traditional medicinal uses various other parts these plants by Native Americans, they have not been investigated for activity. Here leaves, stems/twigs, barks sapwoods both were evaluated antiproliferative effects against human colon tumorigenic (HCT‐116, HT‐29, Caco‐2) non‐tumorigenic (CCD‐18Co) cells....
Three new hydrolyzable tannins including two gallotannins, jamutannins A (1) and B (2), an ellagitannin, iso-oenothein C (3), along with eight known phenolic compounds were isolated from the seeds of Eugenia jambolana fruit. The structures elucidated on basis spectroscopic data analysis. All evaluated for α-glucosidase inhibitory effects compared to clinical drug acarbose.
Scope Published data support that gut microbiota play an important role in the pathological process of obesity and related metabolic disorders. In current study, it is investigated whether a standardized extract from Jamun ( Eugenia jambolana ), widely consumed tropical fruit, could alleviate alter microbial community high‐fat diet (HFD)‐fed mice. Methods results C57BL/6 mice are fed either standard (SD) or HFD with without fruit (JFE; 100 mg kg −1 day ) by oral gavage for 8 weeks. JFE...