Levels of obesity-linked non–insulin-dependent diabetes mellitus (NIDDM) and hypertension are highest among indigenous communities in North America. This is linked to changes dietary pattern towards high calorie foods such as sugar, refined grain flour, sweetened beverages. Therefore, a return traditional patterns may help reduce these disease problems because better balance calories beneficial nutrients. Further protective non-nutrient phenolic phytochemicals against NIDDM potentially but...

ABSTRACT Natural α-amylase and α-glucosidase inhibitors from food-grade plants offer an attractive strategy to manage postprandial hyperglycemia for type 2 diabetes management via control of starch breakdown intestinal glucose absorption. In this study, four random sources red white wines as well types teas were investigated inhibitory potential. Water extracts black tea had the highest activity, followed by oolong tea. All randomly selected significant activity compared wine. The correlated...

Ascophyllum nodosum is a brown seaweed that grows abundantly in the Northeast coastal region. In this study, potential of A. for type 2 diabetes management through antioxidant-mediated alpha-glucosidase and alpha-amylase inhibition was investigated. After initial screening 4 locally harvested seaweeds, chosen its highest phenolic content subjected to water extraction. Among extraction ratios 50 g 100 1000 mL at room temperature, g/400 yielded 4.5 mg/g wet weight. For evaluation temperature...

Natural α-amylase and α-glucosidase inhibitors from food-grade plants offer an attractive strategy to control postprandial hyperglycemia for type 2 diabetes management. Concurrently associated macrovascular complication of hypertension can be managed by similar extracts inhibition angiotensin I-converting enzyme (ACE ). In this study, nine types pepper were investigated inhibitory activity against said enzymes. Several had high activity, which was not correlated total phenolic content free...

Fruits of seven fully ripened strawberry cultivars grown in Brazil (Dover, Camp Dover, Camarosa, Sweet Charlie, Toyonoka, Oso Grande, and Piedade) were evaluated for total phenolics, antioxidant activity based on DPPH radical scavenging assay, functionality such as inhibition alpha-amylase, alpha-glucosidase, angiotensin I-converting enzyme (ACE) relevant potentially managing hyperglycemia hypertension. The phenolics content ranged from 966 to 1571 microg gallic acid/g fruit fresh weight...

This study evaluates the potential mechanism of action and bioactivity black tea pomace for type 2 diabetes prevention via inhibition carbohydrate hydrolyzing enzymes. Black leaves were extracted in hot water was 70% acetone. The phenolic content extract (WBT) acetone extracts (AOBT) 5.77 8.9 mg/mL, respectively, both based on same concentration solid extract. subjected to C18 extraction resulting hydrophobic fraction (HBBT) further LH-20 recover a low molecular weight enriched (LMW) high...

Staphylococcus aureus, a Gram-positive organism, is responsible for numerous infections ranging in severity from skin and soft tissue to endocarditis septic arthritis. Further, Staphylococcal food poisoning (SFP) caused by enterotoxigenic staphylococci one of the main food-borne diseases. In this study, several single-seed origin clonal lines herbs Lamiaceae family were screened antimicrobial applications against S. aureus. These have consistent total phenolic content, profile antioxidant...

Abstract The health-relevant functional benefits of Lactobacillus bulgaricus and acidophilus fermented milk soymilk were investigated targeted for management hyperglycemia related complication hypertension using in vitro models. Free radical scavenging-linked antioxidant activity enzyme inhibitory activities linked to (α – amylase α−glucosidase) (angiotensin I converting enzyme, ACE) substrates evaluated assays. These correlated phenolic lactic acid contents. In spite total content...

Local food diversity and traditional crops are essential for cost-effective management of the global epidemic type 2 diabetes associated complications hypertension. Water 12% ethanol extracts native Peruvian fruits such as Lucuma (Pouteria lucuma), Pacae (Inga feuille), Papayita arequipeña (Carica pubescens), Capuli (Prunus capuli), Aguaymanto (Physalis peruviana), Algarrobo (Prosopis pallida) were evaluated total phenolics, antioxidant activity based on 2, 2-diphenyl-1-picrylhydrazyl...

The health-relevant functionality of 10 thermally processed Peruvian Andean grains (five cereals, three pseudocereals, and two legumes) was evaluated for potential type 2 diabetes-relevant antihyperglycemia antihypertension activity using in vitro enzyme assays. Inhibition enzymes relevant managing early stages diabetes such as hyperglycemia-relevant alpha-glucosidase alpha-amylase hypertension-relevant angiotensin I-converting (ACE) were assayed along with the total phenolic content,...

Type 2 diabetes is a serious problem for developed countries. Prevention of prediabetes progression to type with the use natural products appears cost-effective solution. Previously we showed that enzymatically digested low molecular weight chitosan-oligosaccharide (MW) below 1,000 Da (GO2KA1) has potential hyperglycemia management. In this study evaluated effect long-term supplementation GO2KA1 on using db/db mice model. Additionally, sucrase and glucoamylase activities expression, same...

This research investigated the effect of enzymatically digested low molecular weight (MW) chitosan oligosaccharide on type 2 diabetes prevention. Three different samples with varying MW were evaluated in vitro for inhibition rat small intestinal α-glucosidase and porcine pancreatic α-amylase (GO2KA1; <1000 Da, GO2KA2; 1000-10,000 GO2KA3; > 10,000 Da). The results showed that all tested had similar inhibitory activity. Based these observations, we decided to further investigate three at a...

Abstract We have previously reported that administration of low molecular weight chitosan oligosaccharide (GO2KA1) significantly suppressed postprandial blood glucose rise with increased plasma adiponectin and HbA1c levels in animals humans. However, the cellular mechanisms whereby GO2KA1 exerts antihyperglycemic effects still remain to be determined. Using intestinal Caco‐2 cells 3T3‐L1 cells, here we show has dual modes antidiabetic action by (1) inhibiting α‐glucosidase as well...

ABSTRACT An increasing number of studies indicate that regular intake fruits and vegetables have clear links to reduced risk chronic diseases like diabetes cardiovascular disease. The beneficial effects in many cases been attributed the phenolic antioxidant content vegetables. Apples are a major source fiber contain good dietary phenolics with function. Previous epidemiological indicated apples reduces developing type 2 diabetes. Our this is potentially because modulation postprandial...

Red currants (Ribes rubrum L.), black nigrum red and green gooseberries uva-crispa) were evaluated for the total phenolics, antioxidant capacity based on 2, 2-diphenyl-1-picrylhydrazyl radical scavenging assay functionality such as in vitro inhibition of α-amylase, α-glucosidase angiotensin I-converting enzyme (ACE) relevant potential management hyperglycemia hypertension. The phenolics content ranged from 3.2 (green gooseberries) to 13.5 (black currants) mg/g fruit fresh weight. No...

Abstract: During the heat processing of raw ginseng to produce red ginseng, amino acid derivatives such as arginyl‐fructose (AF) and arginyl‐fructosyl‐glucose (AFG) are formed at high levels, through amadori rearrangement, early step Maillard reaction, from arginine glucose or maltose, respectively. However, very limited information is available about effect structural difference between AF AFG on various biological activities. This first report mode action type 2 diabetes management related...