A5079487560- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Drug Transport and Resistance Mechanisms
- Adipose Tissue and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects and Toxicity Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Diet, Metabolism, and Disease
- Toxic Organic Pollutants Impact
- Diet and metabolism studies
- Carcinogens and Genotoxicity Assessment
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacogenetics and Drug Metabolism
- Effects and risks of endocrine disrupting chemicals
- Pregnancy and Medication Impact
University of Washington
2018
University of Rhode Island
2007-2018
University of Illinois Urbana-Champaign
2018
University of Illinois Chicago
2018
Emory University
2018
University of Utah
2018
Yale Cancer Center
2016
Yale University
2016
The study herein determined the role of nuclear factor erythoid 2-related 2 (Nrf2) in pathogenesis hepatic steatosis, insulin resistance, obesity, and type diabetes. Lep(ob/ob)-Keap1-knockdown (KD) mice, which have increased Nrf2 activity, were generated. Markers obesity diabetes measured C57Bl/6J, Keap1-KD, Lep(ob/ob), Lep(ob/ob)-Keap1-KD mice. mice exhibited less lipid accumulation, smaller adipocytes, decreased food intake, reduced lipogenic gene expression. Enhanced activity impaired...
Aims: The purpose of this study was to determine whether 3′-5′-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) and Sirtuin-1 (SIRT1) dependent mechanisms modulate ATP-binding Cassette (ABC) transport protein expression. ABC proteins (ABCC2–4) are essential for chemical elimination from hepatocytes biliary excretion. Nuclear factor-E2 related-factor 2 (NRF2) is a transcription factor that mediates ABCC induction in response inducers liver injury. However, role NRF2 the regulation...
UDP-glucuronosyltransferases (Ugt) catalyze phase II conjugation reactions with glucuronic acid, which enhances chemical polarity and the elimination from body. Few studies have addressed whether Ugt expression activity are affected by liver disease, such as steatosis. The purpose of this study was to determine steatosis induced obesity or fasting could affect mRNA activity. Male C57BL/6J Lep<i><sup>ob/ob</sup></i> (<i>ob/ob</i>) mice were fed ad libitum food withheld for 24 h. In steatotic...
Sirtuin1 (Sirt1; mammalian homolog of Saccharomyces cerevisiae enzyme Sir2) is a transcriptional and transactivational regulator murine farnesoid X receptor (Fxr), which the primary bile acid (BA) sensor, critical BA metabolism in physiological pathophysiological conditions. Previous studies have suggested compromised Sirt1 expression rodent models cholestatic liver injury. We hypothesized that could be potentially targeted to alleviate In cultured human hepatocytes, SIRT1 messenger RNA was...
This article is a report on symposium entitled "Physiological Regulation of Drug Metabolism and Transport" sponsored by the American Society for Pharmacology Experimental Therapeutics held at Biology 2017 meeting in Chicago, IL. The contributions physiologic pathophysiological regulation drug-metabolizing enzymes transporters to interindividual variability drug metabolism are increasingly recognized but many cases not well understood. presentations herein discuss phenomenology, consequences,...
To evaluate whether Nrf2 deficiency impacts insulin resistance and lipid accumulation in liver white adipose tissue. Lep(ob/ob) mice (OB) with targeted deletion (OB-Nrf2KO) were generated. Pathogenesis of obesity type 2 diabetes was measured C57BL/6J, Nrf2KO, OB, OB-Nrf2KO mice. Hepatic content, clearance, very low-density lipoprotein (VLDL) secretion determined between OB exhibited decreased tissue mass adipogenic lipogenic gene expression compared prolonged hyperglycemia response to...
The multidrug resistance-associated proteins (Mrps) are a family of adenosine triphosphate-dependent transporters that facilitate the movement various compounds, including bile acids, out hepatocytes. current study was conducted to determine whether induction these alters acid disposition as means hepatoprotection during acid-induced cholestasis. Lithocholic (LCA) used induce intrahepatic C57BL/6 mice were pretreated with corn oil (CO) or known transporter inducers, phenobarbital (PB),...