A5070481752- Pomegranate: compositions and health benefits
- Phytochemicals and Antioxidant Activities
- Cynara cardunculus studies
- Sesame and Sesamin Research
- Antioxidant Activity and Oxidative Stress
- Metal complexes synthesis and properties
- Bioactive Compounds in Plants
- Sirtuins and Resveratrol in Medicine
- Plant-Derived Bioactive Compounds
- Tea Polyphenols and Effects
- Garlic and Onion Studies
- Curcumin's Biomedical Applications
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Ginkgo biloba and Cashew Applications
- Tannin, Tannase and Anticancer Activities
- Synthesis and biological activity
- Phytoestrogen effects and research
- Angiogenesis and VEGF in Cancer
- Extracellular vesicles in disease
- Pharmacological Effects of Natural Compounds
- Hops Chemistry and Applications
- Gut microbiota and health
- Crystallization and Solubility Studies
- Protein Interaction Studies and Fluorescence Analysis
Centro de Edafología y Biología Aplicada del Segura
2016-2025
Consejo Superior de Investigaciones Científicas
2012-2025
Centre d'Etudes Biologiques de Chizé
2013-2025
Quality Research
2018-2019
Universidad de Murcia
2009-2018
University of Rhode Island
2011-2016
Centro Médico Sanitas Murcia
2015
Madrid Institute for Advanced Studies
2015
Universidad Autónoma de Madrid
2015
University of Parma
2015
The naturally occurring polyphenol resveratrol has been acknowledged with health-beneficial properties. Most of the studies dealing its in vivo effects assay huge doses, not representative from a dietary point view. Our aim was to ascertain whether can exert anti-inflammatory activity at an attainable dose. Rats were fed 1 mg resveratrol/kg/day (a human equivalent dose) for 25 days, and last 5 5% dextran sulfate sodium (DSS) administered induce colitis. Effects on colon tissue damage, gut...
Scope Urolithins are bioactive metabolites produced by the gut microbiota from ellagitannins (ETs) and ellagic acid (EA). We investigated whether urolithins could be detected in colon tissues colorectal cancer (CRC) patients after pomegranate extract (PE) intake. Methods results CRC (n = 52) were divided into controls PEs consumers (900 mg/day for 15 days) before surgical resection. with low (PE-1) high (PE-2) punicalagin:EA ratio administered. Twenty-three metabolites, but no ellagitannins,...
Scope The pomegranate lipid‐lowering properties remain controversial, probably due to the interindividual variability in polyphenol (ellagitannins) metabolism. Objective We aimed at investigating whether microbially derived ellagitannin‐metabolizing phenotypes, i.e. urolithin metabotypes A, (UM‐A), B (UM‐B), and 0 (UM‐0), influence effects of extract (PE) consumption on 18 cardiovascular risk biomarkers healthy overweight‐obese individuals. Methods results A double‐blind, crossover,...
Urolithins A and B (hydroxy-6H-dibenzo[b,d]pyran-6-one derivatives) are colonic microflora metabolites recently proposed as biomarkers of human exposure to dietary ellagic acid derivatives. Molecular models suggest that urolithins could display estrogenic and/or antiestrogenic activity. To this purpose, both other known phytoestrogens (genistein, daidzein, resveratrol, enterolactone) were assayed evaluate the capacity induce cell proliferation on estrogen-sensitive breast cancer MCF-7 cells...
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly attributed to PJ ellagitannins (ETs). Our aim was assess whether ETs or their metabolites ellagic acid and urolithins reach human upon consumption ET-rich foods evaluate effect on expression three proliferation biomarkers. Sixty-three patients with BPH PCa were divided into controls consumers walnuts (35 g walnuts/day) pomegranate...
Previous studies have reported the anti-inflammatory properties of pomegranate extracts, suggesting that ellagitannins (ET) and ellagic acid (EA) are main compounds. However, both ET EA metabolised in vivo by gut microbiota to yield urolithins (Uro) which can be found systemic bloodstream. The present study was carried out evaluate individual effect their microbiota-derived metabolites Uro on colon fibroblasts upon IL-1β treatment as an vitro inflammation model. Uro-A Uro-B (10 μ m )...
Scope Numerous in vitro and vivo studies indicate that ellagitannins exhibit anti‐inflammatory, anti‐atherosclerotic anti‐angiogenic activity which support their potential preventive effect against cardiovascular diseases. Ellagitannins low bioavailability are transformed the gut to ellagic acid its microbiota metabolites urolithin A (Uro‐A) B (Uro‐B). Urolithins found plasma mostly as glucuronides at μ M concentrations. We investigated whether aglycones vascular protective effects. Methods...
Ellagic acid (EA) is a polyphenol that must be released from the non-bioavailable ellagitannins in pomegranates, walnuts or strawberries to absorbed. To estimate whether EA bioavailability could improved after consumption of high free amount, we conducted crossover pharmacokinetic study healthy volunteers consumed two pomegranate extracts providing either 130 mg punicalagin+524 (PE-1) 279 punicalagin+25 (PE-2). Targeted metabolomics (UPLC-ESI-qTOF-MS/MS) identified plasma but not phase-II...
Human urolithin gut microbiota metabotypes are mainly determined by aging.
Novel gene expression profiles and cellular functions modulated in Caco-2 cells response to the dietary polyphenol, ellagic acid (EA), its colonic metabolites, urolithin-A (3,8-dihydroxy-6H-dibenzo[b,d] pyran-6-one) urolithin-B (3-hydroxy-6H-dibenzo[b,d] have been identified. Exposure of EA urolithins arrested cell growth at S- G(2)/M-phases. Transcriptional profiling using microarray functional analysis revealed changes levels MAPK signalling genes such as, factor receptors (FGFR2, EGFR),...
Oxidative stress is involved in cell death neurodegenerative diseases. Dietary polyphenols can exert health benefits, but their direct effects on neuronal cells are debatable because most phenolics metabolized and do not reach the brain as they occur dietary sources. Herein, we evaluate of a panel bioavailable derived metabolites at physiologically relevant conditions against H2O2-induced apoptosis human neuroblastoma SH-SY5Y cells. Among 19 tested, 3,4-dihydroxyphenylpropionic acid,...
Gut microbiota dysbiosis, intestinal barrier failure, obesity, metabolic endotoxemia, and pro-inflammatory status promote cardiovascular risk. However, the modulation of gut microbiome to prevent endotoxemia in obesity has been scarcely studied. We investigated association between plasma lipopolysaccharide-binding protein (LBP), a surrogate marker overweight-obese individuals.In randomized trial, 49 subjects (body mass index> 27 kg m-2 ) with mild hypelipidemia daily consumed, cross-over...
The ellagic acid-derived gut microbiota metabolite, urolithin A, at concentrations achievable in the human colorectum, enhances anticancer effects of 5-FU-chemotherapy on three different colon cancer cells.