A5010532230- Sirtuins and Resveratrol in Medicine
- Drug Solubulity and Delivery Systems
- Adipokines, Inflammation, and Metabolic Diseases
- TiO2 Photocatalysis and Solar Cells
- Antioxidant Activity and Oxidative Stress
- Pharmaceutical and Antibiotic Environmental Impacts
- Advanced Photocatalysis Techniques
- Tea Polyphenols and Effects
- Bone Tissue Engineering Materials
- Adipose Tissue and Metabolism
- Surfactants and Colloidal Systems
- Water Quality Monitoring and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Silk-based biomaterials and applications
- Cynara cardunculus studies
- Pomegranate: compositions and health benefits
- Electrospun Nanofibers in Biomedical Applications
- Enzyme Catalysis and Immobilization
- Bioactive natural compounds
- Microencapsulation and Drying Processes
- Calcium Carbonate Crystallization and Inhibition
- Polysaccharides Composition and Applications
- Thermal Regulation in Medicine
- Advanced Biosensing Techniques and Applications
- Protein Interaction Studies and Fluorescence Analysis
Universidad Católica San Antonio de Murcia
2016-2024
Universidad de Murcia
2009-2020
Centro Médico Sanitas Murcia
2020
Centro de Edafología y Biología Aplicada del Segura
2009-2014
Consejo Superior de Investigaciones Científicas
2011-2013
University of Florence
2009
The naturally occurring polyphenol resveratrol has been acknowledged with health-beneficial properties. Most of the studies dealing its in vivo effects assay huge doses, not representative from a dietary point view. Our aim was to ascertain whether can exert anti-inflammatory activity at an attainable dose. Rats were fed 1 mg resveratrol/kg/day (a human equivalent dose) for 25 days, and last 5 5% dextran sulfate sodium (DSS) administered induce colitis. Effects on colon tissue damage, gut...
The grape and wine polyphenol resveratrol exerts cardiovascular benefits but evidence from randomized human clinical trials is very limited. We investigated dose-depending effects of a resveratrol-containing supplement on stable patients with coronary artery disease (CAD) treated according to currently accepted guidelines for secondary prevention disease.In triple-blind, randomized, placebo-controlled, one-year follow-up, 3-arm pilot trial, 75 stable-CAD received 350 mg/day placebo, extract...
Scope Urolithins are bioactive metabolites produced by the gut microbiota from ellagitannins (ETs) and ellagic acid (EA). We investigated whether urolithins could be detected in colon tissues colorectal cancer (CRC) patients after pomegranate extract (PE) intake. Methods results CRC (n = 52) were divided into controls PEs consumers (900 mg/day for 15 days) before surgical resection. with low (PE-1) high (PE-2) punicalagin:EA ratio administered. Twenty-three metabolites, but no ellagitannins,...
Scope The cardioprotective role of resveratrol as part the human diet is not yet clear. Our aim was to investigate effect a grape supplement containing 8 mg in oxidized LDL ( ox), apolipoprotein‐ B A po ), and serum lipids on statin‐treated patients primary cardiovascular disease prevention PCP ). Methods results triple‐blind, randomized, placebo‐controlled trial conducted. Seventy‐five (three parallel arms) consumed one capsule (350 mg) daily for 6 months resveratrol‐enriched extract GE ‐...
Abstract Scope : trans ‐Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using pig, a mammal physiologically close humans. Methods results Forty‐seven tissues, organs fluids were analyzed 6 h after intragastric administration (5.9 mg/kg body weight) HPLC‐MS/MS. Twelve seven dihydroresveratrol (DH‐RES) detected. DH‐RES main metabolite cecum, colon rectum, whereas RES‐3‐ O ‐glucuronide most abundant one...
Scope Carnosic acid (CA) and derived diterpenes abundant in rosemary extracts (REs) exert anti‐obesity effects. The aim of this study was to investigate the bioavailability these compounds a rat model obesity. Methods results A total 26 were tentatively identified based on accurate mass information isotopic pattern provided by TOF‐MS analyzer. main metabolites detected gut content, liver, plasma glucuronide conjugates CA, carnosol, rosmanol. Two other also identified: CA 12‐methyl ether...
There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring polyphenol resveratrol exerts anti-inflammatory properties. However, its rapid metabolism diminishes effectiveness in the colon. design of prodrugs to targeting active molecules colon provides an opportunity therapy IBDs. Herein we explore efficacy different and pro-prodrugs ameliorate inflammation murine dextran sulfate sodium (DSS) model. Mice fed with a very low dose...
In this study, we investigated the ability of general anesthetic propofol (PR) to form inclusion complexes with modified β-cyclodextrins, including sulfobutylether-β-cyclodextrin (SBEβCD) and hydroxypropyl-β-cyclodextrin (HPβCD). The PR/SBEβCD PR/HPβCD were prepared characterized, blood-brain barrier (BBB) permeation potential formulated PR was examined in vivo for purpose controlled drug delivery. complex found be more stable solution a minimal degradation constant 0.25 h-1, t1/2 2.82 h, Kc...
The objective of the present study is to obtain linalool- cyclodextrin (CDs) solid complexes for possible applications in food industry. For this purpose, a detailed linalool complexation was carried out at different pH values, optimize type CDs and reaction medium that support highest quantity encapsulated linalool. Once demonstrated ability hydroxypropyl-β-cyclodextrin (HP-β-CDs), form inclusion with (KC = 921 ± 21 L mol−1) given their greater efficacy (6.788) neutral pH, HP-β-CDs were...
A number of pharmacokinetic studies have shown marked differences in the plasma metabolic profile resveratrol (RES) between humans and animals individuals same species, which complicates identification putative bioactive metabolites responsible for beneficial effects RES. On basis physiological similarity pigs humans, aim this work was to characterize pharmacokinetics RES compare values reported humans. (5.9 mg/kg body weight) orally administered pigs. The following were identified using...
Scope Carnosic acid (CA) and rosemary extracts (REs) have antiobesity effects but the mechanisms are not understood. We investigated some of potential contributing to metabolic an RE enriched in CA. Methods results An (∼40% CA) was administered lean (Le, fa /+) obese (Ob, / ) female Zucker rats for 64 days. Several adipocytokines, brain‐derived neurotrophic factor, phosphorylated AMP‐activated protein kinase, hepatic gene expression changes were investigated. The significantly decreased...
The presence of grape and wine polyphenol resveratrol (RES) in the diet is negligible. Therefore, cardiovascular benefits this molecule, a dietary context, remain to be established. We aimed investigate, through intervention, effects resveratrol-rich extract (GE-RES) on prevention early aortic lesions pigs fed an atherogenic (AD). These were compared with those produced by lacking RES (GE) or alone. Pigs AD for 4 months showed atherosclerotic thoracic aorta: degeneration fragmentation...