A5088156747- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Vanadium and Halogenation Chemistry
- Radioactive element chemistry and processing
- Metal-Catalyzed Oxygenation Mechanisms
- Molecular Sensors and Ion Detection
- Metalloenzymes and iron-sulfur proteins
- Organometallic Complex Synthesis and Catalysis
- Magnetism in coordination complexes
- DNA and Nucleic Acid Chemistry
- Synthesis and biological activity
- Electrocatalysts for Energy Conversion
- Synthesis and Characterization of Heterocyclic Compounds
- Polyoxometalates: Synthesis and Applications
- Asymmetric Hydrogenation and Catalysis
- Cancer, Lipids, and Metabolism
- Click Chemistry and Applications
- Electrochemical Analysis and Applications
- Inflammatory mediators and NSAID effects
- Inorganic Chemistry and Materials
- Porphyrin and Phthalocyanine Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Carbon dioxide utilization in catalysis
- Advanced biosensing and bioanalysis techniques
Old Dominion University
2015-2024
Dominion University College
2013-2018
University of Southern Mississippi
2006-2013
Colorado State University
2005-2009
University of Trinidad and Tobago
2009
Charles University
2007
University of Southern California
2007
Loyola University Chicago
2007
University of Arkansas for Medical Sciences
2007
Virginia Tech
2002-2007
A novel microwave-assisted synthetic method has been used to synthesise a series of mixed ligand ruthenium(II) compounds containing diimine as well bidentate thiosemicarbazone ligands. The contain the 1,10-phenanthroline (phen) or 2,2′-bipyridine (bpy) and is derived from 9-anthraldehyde. Based on elemental analyses spectroscopic data, are best formulated [(phen)2Ru(thiosemicarbazone)](PF6)2 where = 9-anthraldehydethiosemicarbazone, 9-anthraldehyde-N(4)-methylthiosemicarbazone,...
Mixed-metal supramolecular complexes that couple ruthenium or osmium based light absorbers to a central rhodium(III) core have been designed which photocleave DNA upon irradiation with visible light. The [{(bpy)2Ru(dpp)}2RhCl2](PF6)5, [{(bpy)2Os(dpp)}2RhCl2](PF6)5, and [{(tpy)RuCl(dpp)}2RhCl2](PF6)3, where bpy = 2,2'-bipyridine, tpy 2,2':6',2' '-terpyridine, dpp 2,3-bis(2-pyridyl)pyrazine, all exhibit intense metal ligand charge transfer (MLCT) transitions in the but possess lower lying...
[VO(Sal-L-tryp)(H2O)] 1 (where sal-L-tryp = N-salicylidene-L-tryptophanate) was used as a precursor to produce the novel complexes, [VO(Sal-L-tryp)(MeATSC)].1.5C2H5OH 2 MeATSC 9-Anthraldehyde-N(4)-methylthiosemicarbazone), [VO(Sal-L-tryp)(N-Ethhymethohcarbthio)].H2O 3 N-Ethhymethohcarbthio (E)-N-ethyl-2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide), and [VO(Sal-L-tryp)(acetylethTSC)].C2H5OH 4 acetylethTSC (E)-N-ethyl-2-(1-(thiazol-2-yl)ethylidene)hydrazinecarbothioamide), by...
The in vitro photobiology of the supramolecular complexes [{(bpy)2Ru(dpp)}2RhCl2]Cl5 and [{(bpy)2Os(dpp)}2RhCl2]Cl5 [bpy = 2,2'-bipyridine; dpp 2,3-bis(2-pyridyl)pyrazine] with African green monkey kidney epithelial (Vero) cells was investigated. Previously, have been shown to photocleave DNA presence or absence O2. Vero cell replication uninhibited for exposed metal complex but protected from light. that were complex, rinsed, illuminated >460 nm light showed a response...
Design of inhibitors for amyloid-β (Aβ) peptide aggregation has been widely investigated over the years toward developing viable therapeutic agents Alzheimer's disease (AD). The biggest challenge seems to be inhibiting Aβ at early stages possibly monomeric level, because oligomers are known neurotoxic. In this regard, exploiting metal-chelating property generate molecules that can overcome impediment presents some promise. Recently, one such metal complex containing PtII ([Pt(BPS)Cl2]) was...
l-Ascorbic acid interacts with vanadium(V) over the pH range of 0.4−7.0 to form three different coordination complexes. Both inner- and outer-sphere electron-transfer pathways are proposed vanadium(IV) complexes l-ascorbate or dehydroascorbate, respectively. Effects on l-ascorbic center were observed presumably related speciation ion. Three using ambient-temperature electron paramagnetic resonance spectroscopy. Two these be complexes, one is consistent a dehydroascorbic complex earlier....
We report the synthesis and characterisation of mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes, which were used as potential photodynamic therapeutic agents for melanoma cell growth inhibition. The novel [Ru(pbt)2(phen2DTT)](PF6)2·1.5H2O 1 (where phen2DTT = 1,4-bis(1,10-phenanthrolin-5-ylsulfanyl)butane-2,3-diol pbt 2-(2'-pyridyl)benzothiazole) [Ru(pbt)2(tpphz)](PF6)2·3H2O 2 tpphz tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine) synthesised characterised. Compound was...
We report the synthesis and characterization of novel mixed-metal binuclear ruthenium(II)–cobalt(II) photocatalysts for hydrogen evolution in acidic acetonitrile. First, 2-(2′-pyridyl)benzothiazole (pbt), 1, was reacted with RuCl3·xH2O to produce [Ru(pbt)2Cl2]·0.25CH3COCH3, 2, which then 1,10-phenanthroline-5,6-dione (phendione), 3, order [Ru(pbt)2(phendione)](PF6)2·4H2O, 4. Compound 4 4-pyridinecarboxaldehyde [Ru(pbt)2(L-pyr)](PF6)2·9.5H2O, 5 (where L-pyr =...
Co(<sc>i</sc>)<italic>versus</italic>Co(<sc>ii</sc>) in cobaloximes. The effect of a coordinated pyridine.
In situ reactions of metal ions or their compounds are important mechanisms by which particles alter lung immune responses. The authors hypothesized that major determinants the immunomodulatory effect any include its redox behavior/properties, oxidation state, and/or solubility, and toxicities arising from differences in physicochemical parameters manifest, part, via differential shifts iron (Fe) homeostasis. To test hypotheses, potentials for both pentavalent vanadium (VV; as soluble...
Background/Aims: Targeting survivin, an anti-apoptotic protein and mitotic regulator, is considered as effective therapeutic option for pancreatic cancer (PaCa). Tolfenamic acid (TA) showed anti-cancer activity in pre-clinical studies. A recent discovery demonstrated a copper(II) complex of TA (Cu-TA) can result higher activity. In this study, the ability Cu-TA to inhibit survivin its transcription factors, Specificity (Sp) 1 3 PaCa cell lines tumor growth mouse xenograft model were...
The electrochemical behavior of a trinuclear ruthenium(II)-containing complex, [((phen)(2)Ru(dpp))(2)RhCl(2)](5+) (where phen = 1,10-phenanthroline, dpp 2,3-bis(2-pyridyl)pyrazine), was studied in acetonitrile (MeCN) and aqueous solutions. In MeCN containing 0.10 M tetra-n-butylammonium perchlorate (TBAP), the complex displayed reversible, overlapping Ru(II/III) redox process with E(1/2) +1.21 V vs Ag/Ag(+) (10 mM), an irreversible reduction Rh(III/I) at -0.73 Ag/Ag(+), two quasi-reversible...
The Mo(3)SnS(4)(6+) single cube is obtained by direct addition of Sn(2+) to [Mo(3)S(4)(H(2)O)(9)](4+). UV-vis spectra the product (0.13 mM) in 2.00 M HClO(4), Hpts, and HCl indicate a marked affinity Sn for Cl(-), with formation more strongly yellow [Mo(3)(SnCl(3))S(4)(H(2)O)(9)](3+) complex complete as little 0.050 Cl(-). X-ray crystal structure (Me(2)NH(2))(6)[Mo(3)(SnCl(3))S(4)(NCS)(9)].0.5H(2)O has been determined gives Mo-Mo (mean 2.730 Å) Mo-Sn 3.732 distances, difference close 1 Å....
Increasing the understanding of how metal ions/complexes react in situ will allow for improved specificity and controlled toxicity novel synthetic metallocompounds that be used as inhaled diagnostics or therapeutics. Our previous work showed inhalation select metals (e.g., chromium, vanadium, nickel, iron) caused alterations lung immune cell function local bacterial resistance. The data also suggested variations degree immuno-modulation induced were not solely dependent on amount deposited...
The in situ reactions of metal ions/complexes are important understanding the mechanisms by which environmental and occupational particles alter lung immune responses. A better these will also allow for improved specificity controlled toxicity novel metallocompounds to be used as inhaled diagnostics or therapeutics. Our previous work showed that inhalation metals (e.g., chromium, vanadium, nickel) caused altered cell function host resistance. data suggested degree immunomodulation induced...