A5065082245- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Coordination Chemistry and Organometallics
- Synthesis and characterization of novel inorganic/organometallic compounds
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Magnetism in coordination complexes
- Organometallic Compounds Synthesis and Characterization
- Metal-Organic Frameworks: Synthesis and Applications
- Asymmetric Hydrogenation and Catalysis
- Organoboron and organosilicon chemistry
- Asymmetric Synthesis and Catalysis
- Inorganic Chemistry and Materials
- Synthetic Organic Chemistry Methods
- Polyoxometalates: Synthesis and Applications
- Fluorine in Organic Chemistry
- Boron Compounds in Chemistry
- Metalloenzymes and iron-sulfur proteins
- Chemical Synthesis and Analysis
- Lanthanide and Transition Metal Complexes
- Catalytic Cross-Coupling Reactions
- Organic and Molecular Conductors Research
- Chemical Synthesis and Characterization
Newcastle University
2016-2025
Newcastle upon Tyne Hospital
2013-2020
Prudhoe Hospital
2019
University of Neuchâtel
2019
University of Cambridge
1987-2016
University of Newcastle Australia
2002-2011
University of Liverpool
2001-2010
University of St Andrews
1996-2010
University of Strathclyde
1991-2010
University of Warwick
1999-2010
The method of fitting a learnt and continually revised profile to X-ray diffraction step-scan measurements, previously described for protein crystals linear diffractometer, has been modified extended wider range samples four-circle diffractometer. Variation peak width is dealt with by assuming an anisotropic functional form, the parameters which are derived least-squares refinement from measurements selected strong reflexions. effect α doublet on reflexion shape treated empirical method,...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Highly π-Stacked Organic Semiconductor for Thin Film Transistors Based on Fused ThiophenesXiao-Chang Li, Henning Sirringhaus, Francis Garnier, Andrew B. Holmes, Stephen C. Moratti, Neil Feeder, William Clegg, Simon J. Teat, and Richard H. FriendView Author Information Melville Laboratory Polymer Synthesis Department of Chemistry, University Cambridge Pembroke Street, CB2 3RA, U.K. Cavendish Laboratory, Physics Madingley Road, CB3 0HE,...
The development of bimetallic aluminium-salen complexes [{Al(salen)}(2)O] as catalysts for the synthesis cyclic carbonates (including commercially important ethylene and propylene carbonates) from a wide range terminal epoxides in presence tetrabutylammonium bromide cocatalyst is reported. structure one complex was confirmed by X-ray crystallography. displayed exceptionally high catalytic activity could catalyse carbonate at atmospheric pressure room temperature. Catalyst-reuse experiments...
Co-crystal screening is routinely undertaken using high-throughput solution growth. We report a low- to medium-throughput approach, encompassing both melt and crystallization step as route the identification of co-crystals. Prior studies, growth was included utilizing Kofler mixed fusion method. This method allowed elucidation thermodynamic landscape within binary phase diagram found increase overall efficiency. The pharmaceutically acceptable adduct nicotinamide selected screened against...
Slow sublimation of the dithiadiazolyl radical 1 yields crystals a new polymorph 1β (orthorhombic, space group Fdd2). Below 36 K this phase exhibits spontaneous magnetic moment, which is described in terms canted antiferromagnetism.
The reactions of the BB-bonded compounds B2(cat)2 (cat = 1,2-O2C6H4) (1a), B2(4-Butcat)2 (1b), and B2(OCMe2CMe2O)2 (1c) with Pt(0)-bis(phosphine) complex [(PPh3)2Pt(η-C2H4)] (4) via oxidative addition BB bond yield cis-bis(boryl) Pt(II) complexes. molecular structures cis-[(PPh3)2Pt(Bcat)2]·C6D6 (3a) cis-[(PPh3)2Pt(B-4-Butcat)2] (3b) were determined by single-crystal X-ray diffraction. Reaction 3a 1 equiv bidentate phosphine dppe (Ph2PCH2CH2PPh2) or dppb (Ph2P(CH2)4PPh2) proceeds smoothly in...
A highly active and selective catalyst for the production of methyl propanoate via methoxycarbonylation ethene is described, based on new zero valent palladium complex L2Pd(dba) [where L2 = 1,2-bis(di-tert-butylphosphinomethyl)benzene dba trans,trans-dibenzylideneacetone].
Several diorganoscandium complexes stabilized by the β-diketiminato ligands (Ar)NC(R)CHC(R)N(Ar) (Ar = 2,6-iPr-C6H3; R CH3 (ligand a), tBu b)) have been synthesized. Reaction of lithium salts with ScCl3·3THF leads to LScCl2(THF)n, which may be readily alkylated form dialkyl derivatives. Most are isolated as base-free, four-coordinate complexes. characterized via X-ray crystallography, and a detailed discussion their structures is presented. Steric interactions between Ar Sc−alkyl groups...
Two new bis-bidentate bridging ligands have been prepared, L (naph) and (anth), which contain two chelating pyrazolyl-pyridine units connected to an aromatic spacer (naphthalene-1,5-diyl anthracene-9,10-diyl respectively) via methylene connectors. Each of these reacts with transition metal dications having a preference for octahedral coordination geometry afford {M 8L 12} (16+) cages (for M = Cu, Zn; (naph), Co, Ni, Cd) approximately cubic arrangement ions ligand spanning each the twelve...
Inhibition of the MDM2-p53 interaction has been shown to produce an antitumor effect, especially in MDM2 amplified tumors. The isoindolinone scaffold proved be versatile for discovery antagonists. Optimization previously reported inhibitors, example, NU8231 (7) and NU8165 (49), was guided by NMR titrations, which indicated key areas binding explored. Variation 2-N-benzyl 3-alkoxy substituents resulted identification...
Abstract Helically chiral N , O ‐boron chelated dipyrromethenes showed solution‐phase circularly polarized luminescence (CPL) in the red region of visible spectrum ( λ em (max) from 621 to 663 nm). The parent dipyrromethene is desymmetrised through chelation boron by 3,5‐ ortho ‐phenolic substituents, inducing a helical chirality fluorophore. combination high dissymmetry factors (| g lum | up 4.7 ×10 −3 ) and fluorescence quantum yields Φ F 0.73) gave exceptionally efficient emission these...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNew Bifunctional Perfluoroaryl Boranes. Synthesis and Reactivity of the ortho-Phenylene-Bridged Diboranes 1,2-[B(C6F5)2]2C6X4 (X = H, F)'V. Clifford Williams, Warren E. Piers, William Clegg, Mark R. J. Elsegood, Scott Collins, Todd B. MarderView Author Information Department Chemistry, University Calgary 2500 Drive N. W. Calgary, Alberta, Canada T2N 1N4 Newcastle upon Tyne NE1 7RU, England Waterloo Waterloo, Ontario, N2L 3G1 South Road...
A new single-crystal diffraction facility has been constructed on beamline 9 of the SRS at Daresbury Laboratory for study structural problems in chemistry and materials science. The station utilizes up to 3.8 mrad horizontally from 5 T wiggler magnet which can be focused vertically. horizontal focusing is provided by a choice gallium-cooled triangular bent Si (111) or (220) monochromators, giving wavelength range 0.3 1.5 Å. Focusing vertical plane achieved cylindrically zerodur mirror with...
Despite strong twisting of the conjugated system, tetrathiafulvalene homologue 1 reacts with electron acceptor tetracyanoquinonodimethane to give dication 12⊕. The anthracene moiety is embedded in 12⊕ [(TCNQ)4]2⊖, and dithiol rings are twisted 86° respect plane: 1:4 stoichiometry highly conductive salt (σ300K = 60S cm−1) very unusual for TCNQ complexes.
Treatment of ScCl3·THF3 with the lithium salts ligands ArNC(R)CHC(R)NAr, where Ar = 2,6-Pri-C6H3 and R CH3 But, gives LScCl2·nTHF derivatives (R CH3, n 1, 1a; 0, 1b). These compounds can be derivatized by alkylation methyllithium or benzylpotassium. The dibenzyl compound prepared from 1a, when treated B(C6F5)3, an ion pair, 4, in which cationic scandium center is stabilized a η6-aryl interaction abstracted borate benzyl group.
In contrast to the solid-state structures of individual compounds, arene-perfluoroarene face-to-face stacking and C–H‥F–C in-plane interactions dominate structure 1∶1 co-crystals 1,4-bis(phenylethynyl)-tetrafluorobenzene 1b 1,4-bis(pentafluorophenylethynyl)- benzene 1c, with this supramolecular aggregation leading stabilisation a nematic liquid crystalline phase.
The complexes [Pt(bipy){CC-(4-pyridyl)}(2)] (1) and [Pt(tBu(2)bipy){CC-(4-pyridyl)}(2)] (2) [Pt(tBu(2)-bipy)(CC-phen)(2)] (3) all contain a Pt(bipy)(diacetylide) core with pendant 4-pyridyl (1 2) or phenanthroline units which can be coordinated to {Ln(diketonate)(3)} fragments (Ln = lanthanide) make covalently-linked Pt(II)/Ln(III) polynuclear assemblies in the Pt(II) chromophore, absorbing visible region, used sensitise near-infrared luminescence from Ln(III) centres. For 1 2...
Alkali metal zincate reagents are attracting considerable attention at present in respect to their often special reactivity/selectivity hydrogen-metal and halogen-metal interconversion reactions. Heteroleptic diorgano-amidozincates, typified by lithium di-tert-butyltetramethylpiperidinozincate, have proved be especially useful such applications. In this paper the related sodium TMP-zincate, prepared as its TMEDA (N,N,N',N'-tetramethylethylenediamine) adduct,...
The πs have it: An unusual 2:1 arene–perfluoroarene π complex is formed between 1,4-bis(phenylethynyl)benzene and its perfluorinated analogue, this the first example of a non-1:1 type. interstack geometry (see picture; red H, green F) also unusual, as mesomorphism system. Supporting information for article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53828_s.pdf or from author. Please note: publisher not responsible content functionality any supporting supplied by...
The half-sandwich methylimido complexes [Nb(η-C5R5)(NMe)Cl2](R = H 1a, or Me 1b) have been prepared by treatment of [Nb(η-C5R5)Cl4] with NMe(SiMe3)2 in acetonitrile. sterically hindered alkyl- and aryl-imido analogues [Nb(η-C5H5)(NR)Cl2](R But1c, C6H3Pri2-2,6 1d), [Nb(η-C5Me5)(N-C6H3Pri2-2,6)Cl2]1e the tantalum compound [Ta(η-C5Me5)(N-C6H3Pri2-2,6)Cl2]1f are obtained [M(η-C5R5)Cl4] two equivalents NHR(SiMe3) chlorocarbon solvent. Crystal structures 1c, 1d 1f show that these mononuclear...
Move over directed ortho-metalation, here comes meta-metalation. The unprecedented meta-zincation of two anilides by a synergic mixed sodium/zinc dialkyl–amide base is presented. orientation the deprotonation remarkably switched to meta site using this heterometallic mixed-metal system. Supporting information for article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600720_s.pdf or from author. Please note: publisher not responsible content functionality any...
Reaction of 4,4′-bipyridine (4,4′-bipy) with barbituric (BAH), orotic (ORH), and uracil-5-carboxylic acids (U5CAH) yielded three new products, which have been characterized by single-crystal X-ray diffraction. The products include a co-crystal neutral species Z′ = 2 (4,4′-bipy/BAH), an organic complex ion pair (4,4′-bipy/ORH) compound containing both ionic hydrogen-bonded (4,4′-bipy/U5CAH). Partial proton transfer is observed in the cases, all structures crystal packing arrangement such that...