A5061437207- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Bipolar Disorder and Treatment
- Menstrual Health and Disorders
- Advanced Breast Cancer Therapies
- Schizophrenia research and treatment
- Mental Health Research Topics
- Computational Drug Discovery Methods
- Treatment of Major Depression
- Child and Adolescent Psychosocial and Emotional Development
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS drug development and treatment
- Genetics, Bioinformatics, and Biomedical Research
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Mental Health and Psychiatry
- Genetics and Neurodevelopmental Disorders
- Biochemical effects in animals
- Chronic Lymphocytic Leukemia Research
- DNA Repair Mechanisms
- Genetic Associations and Epidemiology
Newcastle University
2016-2025
Cancer Research UK
2020-2022
Google (United States)
2018
The University of Arizona Global Campus
2018
Newcastle upon Tyne Hospital
2018
University of Oxford
2007-2016
University of Newcastle Australia
2014
Columbia University
1997-2012
New York State Psychiatric Institute
1993-2012
MRC Laboratory of Molecular Biology
2002-2012
It is frequently reported that patients with psychotic disorders have poor insight into their illness. Previous research has suggested may considerable power in predicting the long-term course of chronic mental and an impact on patients' compliance treatment plans. The authors, proposing best viewed as a multidimensional phenomenon, developed Scale to Assess Unawareness Mental Disorder, which samples discrete global aspects across variety manifestations This article reports reliability...
Background:The goal of this study was to investigate psychosocial disability in relation depressive symptom severity during the long-term course unipolar major disorder (MDD).Methods: Monthly ratings impairment life functions and social relationships were obtained an average 10 years' systematic follow-up 371 patients with MDD National Institute Mental Health Collaborative Depression Study.Random regression models used examine variations functioning associated 3 levels asymptomatic...
<b><i>Background:</i></b> Migraine is a highly prevalent and disabling illness that remains substantially undiagnosed in primary care. Because of the potential value screening tool, current study was designed to establish validity reliability brief, self-administered migraine screener patients with headache complaints care setting. <b><i>Methods:</i></b> A total 563 presenting for routine appointments reporting headaches past 3 months completed screener. All were then referred an independent...
Abstract CDK1 is the only essential cell cycle CDK in human cells and required for successful completion of M-phase. It founding member family conserved across all eukaryotes. Here we report crystal structures complexes CDK1–Cks1 CDK1–cyclin B–Cks2. These confirm nature inactive monomeric fold its ability to be remodelled by cyclin binding. Relative CDK2–cyclin A, B less thermally stable, has a smaller interfacial surface, more susceptible activation segment dephosphorylation shows...
This analysis aimed to quantify the long-term stability of distinctions between nonbipolar, bipolar II, and I affective disorders determine predictors shifts in patients' diagnoses among these categories.Probands entered study as they sought treatment for manic, major depressive, or schizoaffective disorder diagnosed according Research Diagnostic Criteria. After thorough baseline evaluations, 605 patients with nonbipolar depressive disorder, depressed type; 96 II disorder; 231 manic type,...
The Premenstrual Assessment Form (PAF) is a new self report procedure designed to measure changes in mood, behavior, and physical condition during the premenstrual period. It reflects great variability of syndromes as opposed common practice viewing these single entity. In comparison commonly used procedures, PAF 1) contains broader variety more specific descriptions positive well negative changes; 2) provides Unipolar Summary Scales Bipolar Continua which are sensitive measures for indexing...
Of 316 patients with a major depressive disorder who were followed for between 6 months and 2 years, 80 (25%) had preexisting chronic minor depression of at least years' duration. The reduced the apparent effect known predictors recovery relapse from predicted very pernicious course depression. Furthermore, longer patient continued to suffer after recovering depression, greater probability that into another would preempt
Ninety-one patients with panic attacks limited historically to depressive episodes had more severe symptoms and were less likely recover during a 2-year follow-up than 417 depressed who did not have attacks. Family study data clearly distinguished another 15 disorder secondary depression; interviewed relatives of significantly primary depression various anxiety disorders. These support the hierarchical system by which many contemporary diagnostic systems separate major depression.
Background. The literature documents that functional impairment is associated with affective disorders. Nevertheless, the choice among thorough, yet brief, well-validated assessments of limited. objective this study was to evaluate psychometric properties a brief scale impairment, Range Impaired Functioning Tool (LIFE–RIFT). Method. sample included subjects who presented major depressive disorder at intake into NIMH Collaborative Depression Study (CDS). LIFE–RIFT composed items are in...
We have prepared phosphorylated cyclin-dependent protein kinase 2 (CDK2) for crystallization using the CDK-activating 1 (CAK1) fromSaccharomyces cerevisiae and grown crystals microseeding techniques. Phosphorylation of monomeric human CDK2 by CAK1 is more efficient than phosphorylation binary CDK2-cyclin A complex. Phosphorylated exhibits histone H1 activity corresponding to approximately 0.3% that observed with fully activated Fluorescence measurements shown Thr160 increases affinity both...
Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 A3/CDK2 soaked into crystals monomeric CDK2. O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor CDK1 CDK2 with respect to ATP (Ki values: CDK1, 5 ± 1 μM; CDK2, 12 3 μM) formed triplet hydrogen bonds (i.e., NH-9 Glu 81, N-3 Leu 83, 2-NH2 83). The bonding CDK inhibition reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU6027, Ki 2.5 0.4 1.3 0.2 μM). Against human tumor cells,...