A5100363628- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Medical Imaging Techniques and Applications
- Cancer Cells and Metastasis
- Drug Transport and Resistance Mechanisms
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Cancer-related Molecular Pathways
- Saffron Plant Research Studies
- Immune Cell Function and Interaction
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Gastric Cancer Management and Outcomes
- Action Observation and Synchronization
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Cancer Risks and Factors
- HER2/EGFR in Cancer Research
- Biosimilars and Bioanalytical Methods
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
National Institutes for Food and Drug Control
2025
University of Electronic Science and Technology of China
2024
Lanzhou University
2023
Lanzhou University Second Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
The University of Texas MD Anderson Cancer Center
2021-2023
Shanxi University
2015-2023
Second Affiliated Hospital of Shantou University Medical College
2023
Shantou University
2023
Guangzhou University of Chinese Medicine
2023
Hepatocellular carcinoma (HCC) is the major form of liver cancer for which there no effective therapy. Genetic modification with T‐cell receptors (TCRs) specific HCC‐associated antigens, such as α‐fetoprotein (AFP), can potentially redirect human T cells to specifically recognize and kill HCC tumor achieve antitumor effects. In this study, using lentivector peptide immunization, we identified a population cluster differentiation 8 (CD8) in leukocyte antigen (HLA)‐A2 transgenic AAD mice that...
Hyperuricemia was associated with the overproduction or inadequate excretion of uric acid, while its association gut microbiota has emerged although few studies were focused on it. Previously, we have reported a flavonoid extract from saffron floral bio-residues lowered acid in potassium oxonate-induced hyperuricemic mice. In this study, impacts rats evaluated through effects serum, renal, intestinal and xanthine oxidase activity. At same time, microbial metabolic features against...
167 Background: MET is a receptor tyrosine kinase associated with treatment resistance. amplification (MA) results in c-Met overexpression and activation through autodimerization, may be an important oncogenic driver patients (pts) advanced GEC. MA relatively rare primary tumors (<5%), but increase under the selective pressure of systemic therapy. ABT-700 anti-c-Met antibody significant preclinical single-agent activity against human xenograft tumors. Efficacy safety data for GEC are...
Abstract Pain empathy represents a fundamental building block of several social functions, which have been demonstrated to be impaired across various mental disorders by accumulating evidence from case-control functional magnetic resonance imaging (fMRI) studies. However, it remains unclear whether the dysregulations are underpinned robust neural alterations disorders. This study utilized coordinate-based meta-analyses quantitatively determine markers altered pain To support interpretation...
Unsafe practices during illegal plasma donation in the late 1980s and early 1990s spread bloodborne infections central China.A cross-sectional survey of a random sample 538 adult residents 12 villages rural Shanxi Province, where there had been an commercial plasma-collection center, was conducted 2003. Structured questionnaires were administered, blood samples tested for hepatitis C virus (HCV) antibodies.HCV seroprevalence rates 8.2% all subjects, 27.7% former plasma/blood donors, 2.6%...
Cancer stem-like cells (CSCs) have been reported to play major roles in tumorigenesis, tumor relapse, and metastasis after therapy against colorectal carcinoma (CRC). Therefore, identification of CSC regulators could provide promising targets for CRC. Ligand-of-Numb protein X1 (LNX1) is one E3 ubiquitin ligase which mediates the ubiquitination degradation Numb. Although several studies indicate LNX1 be a potential suppressor cancer diseases, functions mediating stemness remain poorly...
Abstract Background Metastasis and invasion are crucial in determining the mortality of cervical carcinoma (CC) patients. The epithelial–mesenchymal transition (EMT) is now a universal explanation for mechanisms tumor metastasis. Α-chimeric protein (α-chimaerin, CHN1) plays an important role regulation signal transduction development. However, molecular regulatory relationships between CHN1 CC progression relation to EMT have not yet been identified. Methods expression tissues, adjacent...
Although we currently have a good understanding of the role C-X-C chemokine receptor type 4 (CXCR4) plays in T cell acute lymphoblastic leukemia (T-ALL), mechanism CXCR4-mediated T-ALL migration remains elusive. Therefore, focus on downstream signals CXCR4 that contribute to this study. Rho GDP-dissociation inhibitor 2 (RhoGDI2) is expressed preferentially lymphocytes. It interacts with and regulates activation proteins by inhibiting dissociation GDP binding GTP. In previous study,...
Only the dried stigma of saffron, a flower deemed as most valuable spice globally, is utilized for industrial production. Hence, there exists growing interest in utilizing saffron floral bio-residues. The anti-hyperuricemic activity flavonoid extract from bio-residues was assessed potassium oxonate-induced hyperuricemia mice. In addition, an ultra-high performance liquid chromatography-triple quadrupole mass spectrometry method established and validated to determine pharmacokinetics five...
This study aimed to enhance the solubility of a poorly water-soluble drug, pranlukast, as well its transport across Madin-Darby canine kidney (MDCK) monolayers, thus increasing oral bioavailability. To accomplish this aim, we prepared pranlukast-phospholipid complex (PPC). The PPC was by solvent-evaporation and characterized transmission electron microscopy (TEM), X-ray diffraction (XRD), infrared (IR) spectroscopy, solubilization studies. pranlukast in increased from 1.03 ± 0.32 μg/ml...
Abstract Background: Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies. Adoptive cellular immunotherapy like chimeric antigen receptor (CAR) T therapy has demonstrated remarkable antitumor activity against B cell However, CAR-T exhibited very limited efficacy in treating AML due to heterogeneity cells and their similarity normal lack leukemic cell-specific targets.LILRB4 (also known as ILT3, CD85k) an immunosuppressive that highly expressed on monocyte blasts...
The aim of the study was to evaluate computed diffusion-weighted images (DWI) in image quality and diagnostic performance rectal cancer by comparing with acquired DWI. A total 103 consecutive patients primary were enrolled this study. All underwent two DWI sequences, namely, conventional acquisition b = 0 1,000 s/mm2 (aDWIb1,000) another 700 on a 3.0T MR scanner (MAGNETOM Prisma; Siemens Healthcare, Germany). (b s/mm2) used compute diffusion value (cDWIb1,000). Qualitative quantitative...