A5050653184- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- Crystal structures of chemical compounds
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Advanced Chemical Sensor Technologies
- Metal complexes synthesis and properties
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Spectroscopy and Chemometric Analyses
- Pesticide Residue Analysis and Safety
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Mycotoxins in Agriculture and Food
- Analytical chemistry methods development
- Hepatitis C virus research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microfluidic and Capillary Electrophoresis Applications
- Traditional Chinese Medicine Analysis
- Advanced biosensing and bioanalysis techniques
- Chemical Analysis and Environmental Impact
- Chromatography in Natural Products
- Mosquito-borne diseases and control
- Quinazolinone synthesis and applications
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Peking Union Medical College Hospital
2015-2023
GTx (United States)
2020
Jingdong (China)
2015
Abstract C 18 H 17 BrFN 5 O 2 , monoclinic, P 1 / c (no. 14), a = 19.3571(8) Å, b 13.4295(12) 7.3036(5) β 93.372(5)°, V 1895.3(2) Å 3 Z 4, R gt ( F ) 0.0407, wR ref 0.0939, T 293(2) K.
The narrow therapeutic index and significant toxicity of colchicine (COL) underscore the importance content uniformity dosage units to ensure drug safety efficacy. In this study, transmission Raman spectroscopy (TRS) technology combined with partial least squares (PLS) regression was used for non-destructive determination low concentration levels COL in commercial tablets (0.83 % w/w). Based on a multifactor orthogonal design experiment, one hundred calibration ranging from 70 130 label...
The novel coronavirus disease (2019-nCoV) has been affecting global health since the end of 2019, and there is no sign that epidemic abating. Targeting interaction between severe acute respiratory syndrome 2 (SARS-CoV-2) spike protein human angiotensin-converting enzyme (ACE2) receptor a promising therapeutic strategy. In this study, surface plasmon resonance (SPR) was used as primary method to screen library 960 compounds. A compound 02B05 (demethylzeylasteral, CAS number: 107316-88-1) had...
Abstract Sulfonate esters, one of the genetic impurities, have gained significant attention in recent years due to their potential cause mutations and cancer. In this study, we reported a novel on‐line column‐switching liquid chromatography method for quantitative analysis three p‐toluene sulfonate alkyl esters active pharmaceutical ingredients (APIs). The sensitivity was improved by large‐volume injection. A diluting modulation‐based sampling procedure specifically devised mitigate impact...
Previous studies have suggested that geldanamycin (GA) inhibits the replication of several viruses in vitro. Here, we aimed to synthesize and evaluate antiviral activity 17-amino-17-demethoxygeldanamycin derivatives.A series 17-substituted 17-,19-disubstituted GA derivatives were screened for activities against eight different viral strains, including herpesvirus, hepatitis virus, retrovirus picornavirus.Most tested compounds showed inhibitory reduced cytotoxicity vitro as compared with...
In recent years, transmission Raman spectroscopy (TRS) has emerged as a potent new tool for rapid, nondestructive quantitation in pharmaceutical manufacturing. order to expand the applicability of TRS and enhance its use product quality monitoring during drug production, we aimed, present study, apply partial least-squares (PLS) approaches build model consisting 150 handmade tablets covering 15 levels through multifactor orthogonal design experiment (DOE), which was used predict...
Human BST-2 inhibits HIV-1 replication by tethering nascent virions to the cell surface. codes Vpu that counteracts down-regulating this restriction factor from This important function makes a potential therapeutic target. Yet, no agents have been reported block antagonizing BST-2. In study, we report small molecule compound IMB-LA abrogates of and thereby strongly suppresses sensitizing virus restriction. Further studies revealed specifically Vpu-mediated degradation restores expression at...
Two new geldanamycin (GDM) analogues, (4S)-4,5-dihydro-4-hydroxygeldanamycin (1) and (4R)-4,5-dihydro-4-hydroxygeldanamycin (2), were identified from Streptomyces hygroscopicus 17997. Compounds 1 2 not normal intermediates of GDM biosynthesis but shunt products C-4,5 oxidation catalyzed by GdmP, a cytochrome P450 oxidase acting as desaturase in biosynthesis. Preliminary assays implied that, compared with GDM, exhibited decreased cytotoxicity.
Genome mining has become an important tool for discovering new natural products and identifying the cryptic biosynthesis gene clusters. Here, we utilized flavin-dependent halogenase GedL as probe in combination with characteristic halogen isotope patterns to mine halogenated secondary metabolites from our in-house fungal database. As a result, two pairs of atropisomers, pestalachlorides A1a (1a)/A1b (1b) A2a (2a)/A2b (2b), along known compounds pestalachloride A (3) SB87-H (4), were...
Summarization of fragmentation behavior saponins in <italic>C. oleifera</italic> for the first time, which was confirmed by LTQ-orbitrap.