A5048580394- Nanoplatforms for cancer theranostics
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Simulation and Modeling Applications
- Nanoparticle-Based Drug Delivery
- Advanced Neural Network Applications
- Nanocluster Synthesis and Applications
- Domain Adaptation and Few-Shot Learning
- Analytical Chemistry and Chromatography
- Cardiac electrophysiology and arrhythmias
- Advanced Nanomaterials in Catalysis
- Robotic Path Planning Algorithms
- Misinformation and Its Impacts
- MRI in cancer diagnosis
- Cardiac pacing and defibrillation studies
- Lanthanide and Transition Metal Complexes
- Topic Modeling
- Advanced Measurement and Detection Methods
- Machine Learning and ELM
- Analytical chemistry methods development
- Advanced Computational Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Infrared Target Detection Methodologies
- Energy Harvesting in Wireless Networks
- Human Motion and Animation
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Soochow University
2024-2025
Peking University First Hospital
2025
Peking University
2025
Second Affiliated Hospital of Soochow University
2025
Fudan University
2025
Chinese Academy of Fishery Sciences
2025
Shanghai Ocean University
2025
Duke-NUS Medical School
2025
Hunan University
2021-2024
Ferroptosis exhibits potential to damage drug-resistant cancer cells. However, it is still restricted with the "off-target" toxicity from undesirable leakage of metal ions ferroptosis agents, and lack reliable imaging for monitoring process in living systems. Herein, we develop a novel ternary alloy PtWMn nanocube as Mn reservoir, further design microenvironment-triggered nanoplatform that can accurately release within tumor increase reactive oxygen species (ROS) generation, produce O2...
Hepatic ischemia–reperfusion (I/R) injury accompanied by oxidative stress is responsible for postoperative liver dysfunction and failure of surgery. However, the dynamic non-invasive mapping redox homeostasis in deep-seated during hepatic I/R remains a great challenge. Herein, inspired intrinsic reversibility disulfide bond proteins, kind reversible redox-responsive magnetic nanoparticles (RRMNs) designed imaging both oxidant antioxidant levels (ONOO–/GSH), based on sulfhydryl...
Ferroptosis, as a type of programmed cell death process, enables effective damage to various cancer cells. However, we discovered that persistent oxidative stress during ferroptosis can upregulate the apurinic/apyrimidinic endonuclease 1 (APE1) protein induces therapeutic resistance ("ferroptosis resistance"), resulting in an unsatisfactory treatment outcome. To address APE1-induced resistance, developed GSH/APE1 cascade activated nanoplatform (GAN). Specifically, GAN is self-assembled by...
Abstract The use of fibular graft for the reconstruction bone defects has been demonstrated to be a reliable method. aim this study was assess clinical outcome union, functional (hypertrophy bones) and complications both non-vascularized vascularized grafts. From 1981 2015, 10 patients were treated using or free graft. outcomes bony union time, hypertrophy based on radiograph according Musculoskeletal Tumor Society (MSTS) score. Mobility ankle at donor site evaluated Kofoed score system....
Abstract Background and objective Cardiovascular disease (CVD) is the leading cause of morbidity mortality in United States. However, current evidence on association between muscle quality CVD limited. This study investigates potential index (MQI) prevalence CVD-related mortality. Methods Participants were selected from National Health Nutrition Examination Survey (NHANES) 2011–2014. Data causes death obtained Death Index (NDI) records through December 31, 2019. Statistical analysis used...
Companion diagnostics using biomarkers have gained prominence in guiding radiotherapy. However, biopsy-based techniques fail to account for real-time variations target response and tumor heterogeneity. Herein, we design an activated afterglow/MRI probe as a companion tool dynamically assessing biomarker apurinic/apyrimidinic endonuclease 1(APE1) during radiotherapy vivo. We employ ultrabright afterglow nanoparticles ultrasmall FeMnOx dual contrast agents, significantly broadening signal...
In recent years, significant progress has been made in China the field of deep-sea large yellow croaker (Larimichthys crocea) farming. Compared with traditional inshore aquaculture model, culture enjoys a wider growing space better water quality, thus enhancing fish quality. However, also faces challenges such as typhoons and strong currents, which often lead to prolonged starvation fish. Therefore, order further promote technological advancement aquaculture, this experiment aimed...
Abstract C 18 H 17 BrFN 5 O 2 , monoclinic, P 1 / c (no. 14), a = 19.3571(8) Å, b 13.4295(12) 7.3036(5) β 93.372(5)°, V 1895.3(2) Å 3 Z 4, R gt ( F ) 0.0407, wR ref 0.0939, T 293(2) K.
An association between white blood cell count (WBC-C) before percutaneous coronary intervention (PCI) and prognosis has been established in patients undergoing PCI. However, the effect of WBC-C after PCI on long-term with unstable angina pectoris (UA) is unclear. A retrospective cohort study was conducted 1811 consecutive UA. The changes WBC subgroup counts early postoperative stages were observed by paired Wilcoxon signed-rank test. Kaplan-Meier method COX proportional regression model used...
Abstract Liver fibrosis (LF) is characterized by excessive production of reactive oxygen species (ROS), abnormal activation hepatic stellate cells (HSCs), and subsequent extracellular matrix (ECM) deposition. The complexity multiple interrelated pathways involved in this process makes it challenging for monotherapy to achieve the desired therapeutic effects. To address issue, study designs a ROS‐activated heterodimer conjugate (VTO) collaboratively alleviate LF. Additionally, biomimetic...
Objective To explore the acceptability of family support through an AI-enabled mobile app and identify preferences for its novel module features among patients with type 2 diabetes (T2DM) members. Methods Semi-structured interviews were conducted T2DM A mock wireframe FAMILY was created to help participants visualize features. All audio-recorded transcribed verbatim. Inductive thematic analysis using constant-comparative method performed interpret patterns within data. Results total 25...
Abstract Ferroptosis exhibits potential to damage drug‐resistant cancer cells. However, it is still restricted with the “off‐target” toxicity from undesirable leakage of metal ions ferroptosis agents, and lack reliable imaging for monitoring process in living systems. Herein, we develop a novel ternary alloy PtWMn nanocube as Mn reservoir, further design microenvironment‐triggered nanoplatform that can accurately release within tumor increase reactive oxygen species (ROS) generation, produce...
Modern convolutional neural networks (CNNs) play a crucial role in computer vision applications. The intricacy of the application scenarios and growing dataset both significantly raise complexity CNNs. As result, they are often overparameterized have significant computational costs. One potential solution for optimizing compressing CNNs is to replace layers with low-rank tensor decomposition. most suitable technique this Canonical Polyadic (CP) However, there two primary issues CP...
Abstract Sulfonate esters, one of the genetic impurities, have gained significant attention in recent years due to their potential cause mutations and cancer. In this study, we reported a novel on‐line column‐switching liquid chromatography method for quantitative analysis three p‐toluene sulfonate alkyl esters active pharmaceutical ingredients (APIs). The sensitivity was improved by large‐volume injection. A diluting modulation‐based sampling procedure specifically devised mitigate impact...