A5100418903- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Epigenetics and DNA Methylation
- HIV/AIDS Research and Interventions
- Immune cells in cancer
- CAR-T cell therapy research
- Global Maternal and Child Health
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Child Nutrition and Water Access
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Influenza Virus Research Studies
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Birth, Development, and Health
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
Fudan University
2002-2025
Johns Hopkins University
2013-2025
Third Xiangya Hospital
2017-2025
Central South University
2012-2025
Peking University
2008-2025
Peking University First Hospital
2008-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Qatar Airways (Qatar)
2024-2025
The Fifth People’s Hospital of Suzhou
2023-2025
Jiangsu Provincial Center for Disease Control and Prevention
2019-2025
BackgroundDespite remarkable progress in the improvement of child survival between 1990 and 2015, Millennium Development Goal (MDG) 4 target a two-thirds reduction under-5 mortality rate (U5MR) was not achieved globally. In this paper, we updated our annual estimates by cause to 2000–15 reflect on toward MDG consider implications for Sustainable Goals (SDG) survival.MethodsWe increased estimation input data causes deaths 43% among neonates 23% 1–59-month-olds, respectively. We used adequate...
Angiogenesis and signaling through the RAF/mitogen-activated protein/extracellular signal-regulated kinase (ERK) (MEK)/ERK cascade have been reported to play important roles in development of hepatocellular carcinomas (HCC). Sorafenib (BAY 43-9006, Nexavar) is a multikinase inhibitor with activity against Raf several receptor tyrosine kinases, including vascular endothelial growth factor 2 (VEGFR2), platelet-derived (PDGFR), FLT3, Ret, c-Kit. In this study, we investigated vitro effects...
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern CoVs (MERS-CoV), and H7N9, cause fatal lung injury (ALI) by driving hypercytokinemia aggressive inflammation through mechanisms that remain elusive. In SARS-CoV/macaque models, we determined anti–spike IgG (S-IgG), in productively infected lungs, causes ALI skewing inflammation-resolving response. Alveolar macrophages underwent functional polarization acutely macaques, demonstrating...
ContextGlucose-insulin-potassium (GIK) infusion is a widely applicable, low-cost therapy that has been postulated to improve mortality in patients with acute ST-segment elevation myocardial infarction (STEMI). Given the potential global importance of GIK infusion, large, adequately powered randomized trial required determine effect on STEMI.ObjectiveTo high-dose STEMI.Design, Setting, and ParticipantsRandomized controlled conducted 470 centers worldwide among 20 201 STEMI who presented...
ABSTRACT The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. source high loads saliva, however, remains elusive. Here we investigate the early target cells infection entire array tissues Chinese macaques after intranasal inoculations with single-cycle pseudotyped virus and pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2 + ) were widely distributed upper tract, ACE2...
Abstract Purpose: To assess the immunologic effects of dabrafenib and trametinib in vitro to test whether potentiates or antagonizes activity immunomodulatory antibodies vivo. Experimental Design: Immune were evaluated human CD4+ CD8+ T cells from healthy volunteers, a panel tumor cell lines, vivo using CT26 mouse model. Results: Dabrafenib enhanced pERK expression levels did not suppress T-cell function. Trametinib reduced levels, resulted partial/transient inhibition...
ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) infection is highly endemic in China, but estimates of the burden are lacking. We established incidence CRE from a multicenter study that covered 25 tertiary hospitals 14 provinces. cases defined as carbapenem-nonsusceptible Citrobacter freundii , Escherichia coli Enterobacter cloacae or Klebsiella pneumoniae infections during January to December 2015 were collected and reviewed medical records. Antimicrobial susceptibility testing...
Recent results from clinical trials with the BRAF inhibitors GSK2118436 (dabrafenib) and PLX4032 (vemurafenib) have shown encouraging response rates; however, duration of has been limited. To identify determinants acquired resistance to strategies overcome resistance, we isolated drug-resistant clones A375 BRAF(V600E) YUSIT1 BRAF(V600K) melanoma cell lines. These also showed reduced sensitivity allosteric mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitor...
Significance Statement Although reports indicate that patients receiving maintenance hemodialysis are at risk for severe illness with coronavirus disease 2019 (COVID-19), information about this population of is limited. Using data retrospectively collected from a registration system included 7154 undergoing 65 hospitals in Wuhan, China, the authors found 154 had laboratory-confirmed COVID-19. In detailed analysis epidemiologic and clinical characteristics 131 COVID-19 who provided oral...
In situ forming hydrogels with simple sol–gel transition are more practicable as injectable for drug delivery and tissue regeneration. State-of-the-art in gelling systems can easily efficiently be formed by different mechanisms situ. Chitosan is a kind of natural polysaccharide that widely exploited biomedical applications due to its good biocompatibility, low immunogenicity specific biological activities. Chitosan-based have already gained much attention smart biomaterials the development...
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes NKTCL based on genomic structural alterations EBV sequences, we performed multi-omics study 128 biopsy samples newly diagnosed defined three prominent subtypes, which differ significantly in origin, gene expression, transcriptional signatures, responses to asparaginase-based regimens targeted...
China has achieved Millennium Development Goal 4 to reduce under-5 mortality rate by two-thirds between 1990 and 2015. In this study, we estimated the national subnational levels causes of child in annually from 1996 2015 draw implications for achievement SDGs other low-income middle-income countries.
Abstract The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding this tumor-specific ecosystem is necessary to enhance cancer diagnosis, therapeutics, prognosis. However, recent advances based on bulk RNA sequencing remain insufficient construct an in-depth landscape infiltrating cells in NPC. Here we apply single-cell 66,627 from 14 patients, integrated with clonotype identification T B cells....
Coronavirus disease 2019 (COVID-19) has a wide spectrum of severity from mild upper respiratory symptoms to failure. The role neutralizing antibody (NAb) response in progression remains elusive. This study determined the seroprevalence 733 non-COVID-19 individuals April 2018 February 2020 Hong Kong Special Administrative Region and compared responses eight COVID-19 patients admitted intensive care unit (ICU) with those 42 not ICU. We found that NAb against SARS-CoV-2 was detectable any...
Abstract Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical interventions against COVID-19 disease. However, their common genetic and biologic features remain elusive. Here we interrogate a total of 165 from eight patients, find that potent nAbs different patients have disproportionally high representation IGHV3-53/3-66 usage, therefore termed as public antibodies. Crystal structural comparison these reveals they share similar angle approach RBD, overlap in...
Background There were seven novel and easily accessed insulin resistance (IR) surrogates established, including the Chinese visceral adiposity index (CVAI), (VAI), lipid accumulation product (LAP), triglyceride glucose (TyG) index, TyG-body mass (TyG-BMI), TyG-waist circumference (TyG-WC) to height ratio (TyG-WHtR). We aimed explore association between IR incident coronary heart disease (CHD), compare their predictive powers among population. Methods This is a 10-year prospective cohort...