A5100318403- Metal complexes synthesis and properties
- Enzyme Catalysis and Immobilization
- Magnetism in coordination complexes
- Ferrocene Chemistry and Applications
- Crystal structures of chemical compounds
- Synthesis and biological activity
- Biochemical and Molecular Research
- Breast Cancer Treatment Studies
- Air Quality and Health Impacts
- Metal-Organic Frameworks: Synthesis and Applications
- Drug Solubulity and Delivery Systems
- Synthesis of Tetrazole Derivatives
- Breast Lesions and Carcinomas
- Flavonoids in Medical Research
- Climate Change and Health Impacts
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Microbial Metabolic Engineering and Bioproduction
- HER2/EGFR in Cancer Research
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Coronary Interventions and Diagnostics
- Plant-based Medicinal Research
- Adipose Tissue and Metabolism
Chongqing Medical University
2014-2025
Harbin Medical University
2009-2025
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Weifang Medical University
2024
Yale University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2024
Fu Wai Hospital
2007-2024
State Key Laboratory of Cardiovascular Disease
2023-2024
Chongqing Cancer Hospital
2024
Second Hospital of Shandong University
2024
ContextGlucose-insulin-potassium (GIK) infusion is a widely applicable, low-cost therapy that has been postulated to improve mortality in patients with acute ST-segment elevation myocardial infarction (STEMI). Given the potential global importance of GIK infusion, large, adequately powered randomized trial required determine effect on STEMI.ObjectiveTo high-dose STEMI.Design, Setting, and ParticipantsRandomized controlled conducted 470 centers worldwide among 20 201 STEMI who presented...
Abstract The randomized, multicenter, double-blind, placebo-controlled, phase III PEONY trial (NCT02586025) demonstrated significantly improved total pathologic complete response (primary endpoint) with dual HER2 blockade in HER2-positive early/locally advanced breast cancer, as previously reported. Here, we present the final, long-term efficacy (secondary endpoints: event-free survival, disease-free overall survival) and safety analysis (62.9 months’ median follow-up). Patients (female; n =...
ACE2 appears to counterbalance the vasopressor effect of angiotensin I converting enzyme (ACE) in reninangiotensin system. We hypothesized that polymorphisms could confer a high risk hypertension and have an impact on antihypertensive response ACE inhibitors. The hypothesis was tested two casecontrol studies clinical trial 3,408 untreated hypertensive patients randomized Atenolol, Hydrochlorothiazide, Captopril, or Nifedipine treatments for 4 weeks. rs2106809 T allele found 1.6-fold women...
Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and leading infant hospitalization worldwide. Uncontrolled response to RSV mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses anti-RSV activity an inhibitor TRIF/TBK1/IRF-3 complex. We hypothesize that resveratrol inhibits TRIF-dependent pathway through upregulation SARM post-RSV infection. BALB/c mice were infected with injected 1 h...
A series of (8-hydroxyquinoline) gallium(III) complexes (CP-1-4) was synthesized and characterized by single X-ray crystallography density functional theory (DFT) calculation. The cytotoxicity the four gallium toward a human nonsmall cell lung cancer line (A549), colon (HCT116), normal hepatocyte (LO2) evaluated using MTT assays. CP-4 exhibited excellent against HCT116 cells (IC50 = 1.2 ± 0.3 μM) lower toxicity than cisplatin oxaliplatin. We also anticancer mechanism studies in uptake,...
Abstract Objectives Baicalin (BCL) has potential therapeutic benefits, but its clinical outcomes are restricted mainly because of low water solubility. This study sought to improve the solubility BCL by formation inclusion complex with β-cyclodextrin (β-CD). Methods The was studied test, differential scanning calorimeter (DSC), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), 1H Nuclear magnetic resonance (1HNMR) and electron microscopy (SEM). Molecular docking...
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, but no drugs can cure this disease. Chalcones possess good antioxidant activity, anti-neuroinflammatory neuroprotective effects, inhibitory effects on Aβ aggregation, and disaggregation ability. Therefore, chalcones are ideal lead compounds, discovery of novel anti-AD agent-based necessary. Hydroxy groups aryl benzyl ether were introduced into chalcone scaffolds to obtain a series 2-hydroxyl-4-benzyloxy derivatives....
Menopausal women undergo substantial physiological changes that can impact their overall health. We examined relationships between circadian rest-activity rhythms (CRARs) and multimorbidity progression in this population. used UK Biobank data, involving 10,138 participants, who were initially free of chronic conditions. primarily focused on the relative amplitude (RA) CRARs, tracking incident first conditions (FCC), multimorbidity, all-cause mortality. Multimorbidity was indicated by...
Three complexes were synthesized and characterized. The cytotoxicity, apoptosis, cellular uptake, reactive oxygen species, mitochondrial membrane potential, cell cycle arrest western blot analysis investigated.
Berberine hydrochloride-loaded carboxymethyl β-cyclodextrin-functionalized montmorillonite nanosheet networks strongly suppressed the bacterial growth over three days.
The development of amorphous solid dispersions (ASD) is one way to overcome the bioavailability challenges poorly water-soluble drug. Herein, Curcumin (CUR) was dispersed in polymeric matrix Eudragit®E100 by solvent evaporation, giving ASD, donated as CUR@Eudragit®E100. Solubility and stability CUR were greatly enhanced. DSC XRD analysis confirmed that incorporated present an state. interaction between investigated through FTIR molecular modelling studies which implied -OH groups CUR,...
During the usage of Rhizopus oryzae whole cell instead immobilized enzyme for biodiesel production, intracellular lipase was found to have 1,3-positional specificity when used catalyze methanolysis triglycerides. Thus, application R. in production from triglycerides is restrained some extent. However, it might be a promising catalyst free fatty acids (FFAs). In this paper, IFO4697 [immobilized within biomass support particles (BSPs)] catalyzed oleic acid studied systematically. It has been...
The supported ionic liquids (SILs) were prepared via immobilizing silane-functionalized (IL) onto the monodispersive silica nanoparticles, and composite material was then applied in immobilization of penicillin G acylase (PGA, EC 3.5.1.11), an important industrial enzyme for production semisynthetic antibiotics. This a novel approach PGA proposed our previous report, which we had studied effects IL types on performance this support. Here, focused loading properties SILs their immobilization....
Enzymes are biocatalysts. In this study, a novel biocatalyst consisting of magnetic combined cross-linked enzyme aggregates (combi-CLEAs) 3-quinuclidinone reductase (QNR) and glucose dehydrogenase (GDH) for enantioselective synthesis (R)-3-quinuclidinolwith regeneration cofactors in situ was developed. The combi-CLEAs were fabricated with the use ammonium sulfate as precipitant glutaraldehyde cross-linker direct immobilization QNR GDH from E. coli BL(21) cell lysates onto...
Abstract Background The objective of this study was to develop a model combining ultrasound (US) and clinicopathological characteristics predict the pathologic response neoadjuvant chemotherapy (NACT) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Materials methods This is retrospective that included 248 patients with HER2-positive cancer who underwent NACT from March 2018 2022. US were collected all study, obtained using univariate analysis at p < 0.1...