A5045556967- Organic Electronics and Photovoltaics
- Traditional Chinese Medicine Analysis
- Organic Light-Emitting Diodes Research
- Luminescence and Fluorescent Materials
- Conducting polymers and applications
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- Ginseng Biological Effects and Applications
- Advanced Sensor and Energy Harvesting Materials
- X-ray Diffraction in Crystallography
- Phytochemistry and biological activity of medicinal plants
- Analytical Methods in Pharmaceuticals
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Carbohydrate Chemistry and Synthesis
- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Enzyme Catalysis and Immobilization
- Free Radicals and Antioxidants
Tianjin University of Traditional Chinese Medicine
2016-2025
Sun Yat-sen University
2024-2025
Nanjing Tech University
2015-2024
Guangdong Academy of Agricultural Sciences
2024
Chongqing Medical University
2007-2024
Ministry of Agriculture and Rural Affairs
2024
Guangzhou Center for Disease Control and Prevention
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2021
The Synergetic Innovation Center for Advanced Materials
2019-2020
Lanzhou University
2020
Abstract The catalytic promiscuity of the novel benzophenone C‐glycosyltransferase, MiCGT, which is involved in biosynthesis mangiferin from Mangifera indica , was explored. MiCGT exhibited a robust capability to regio‐ and stereospecific C‐glycosylation 35 structurally diverse druglike scaffolds simple phenolics with UDP‐glucose, also formed O‐ N‐glycosides. Moreover, able generate C‐xylosides UDP‐xylose. OGT‐reversibility exploited C‐glucosides sugar donor. Three aryl‐C‐glycosides potent...
Emerging evidence highlights the role of gut microbiota in regulating pathogenesis coronary heart disease. Here, we performed 16S rRNA gene sequencing and UPLC-Q-TOF/MS-based metabolomics to investigate microbiome metabolomes cecal contents isoproterenol (ISO)-induced acute myocardial ischemia (AMI) rats. As expected, considerable alterations were observed AMI rats compared with control rats, paralleling intestinal inflammation apoptosis. At phylum level, abundance Firmicutes was...
Abstract Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development. A traditional Chinese herbal formula, Chaihu-Shu-Gan-San (CSGS), has been effectively used treatment of various gastrointestinal (GI) disorders. The present study was carried out to investigate whether CSGS modulates under condition dysbiosis. metabonomics studies biochemical changes urine feces antibiotic-induced rats...
C-Glycosyltransferases (CGTs) are powerful tools for the C-glycosylation of natural and unnatural products. However, CGTs able to catalyze bis-C-glycosylation very rare key amino acids which have not been uncovered. Here, we discovered a C-glycosyltransferase MiCGTb from Mangifera indica that has capacity bis-C-glycosylation. Further studies on active-site motifs revealed I152 was critical acid residue second its S60/V100/T104 residues were pivotal activity. Moreover, developed panel...
Complex internal stresses that appear in flexible thin-film electronic devices under long-term deformation operation are associated with incompatible mechanical properties of the multiple layers, which potentially cause intralayer fracture and separation. These defects may result device instability, performance loss, failure. Herein, a thermoplastic functional strategy is proposed for manufacturing high-performance stretchable semiconducting polymers excellent strain-tolerance capacities...
Plantago, also known as plantain, has been used a traditional herb in Asia for centuries to treat urinary tract inflammation and kidney disease. Recently, there increasing interest its potential applications the food industry. In China, are two common species of, namely Plantago asiatica L.(PAL) P. depressa Willd.(PDW), which not distinguished folk clinical practices, leading safety efficacy risks plantago applications. The objective of this study is establish reliable method differentiating...
Phellodendri Chinensis Cortex (PCC) and Amurensis (PAC) are increasingly being used as traditional herbal medicines, but they often mistaken for each other. In this study, the fingerprints of PCC from six different geographical sources were obtained by high-performance liquid chromatography, multivariate chemometric methods comprehensive analysis. Two unsupervised pattern recognition models (principal component analysis hierarchical cluster analysis) a supervised model (partial least squares...
The intrinsically rigid and limited strain of most conjugated polymers has encouraged us to optimize the extensible properties polymers. Herein, learning from hydrogen bonds in glucose, which were facilitated toughness enhancement cellulose, we introduced interchain polydiarylfluorene by amide-containing side chains. Through tuning copolymerization ratio, systematically investigated their influence on hierarchical condensed structures, rheology behavior, tensile performances, optoelectronic...
Intrinsically stretchable polymeric semiconductors are essential to flexible polymer light-emitting diodes (PLEDs) owing their excellent strain tolerance capacity under long-time deformation operation. Obtaining intrinsic stretchability, robust emission properties, and charge-transport behavior simultaneously from fully π-conjugated polymers (FCPs) is difficult, particularly for applications in deep-blue PLEDs. Herein, an internal plasticization strategy proposed introduce a phenyl-ester...
Introduction Scutellariae Radix (SR), derived from the root of Scutellaria baicalensis Georgi, is a traditional Chinese medicine (TCM) for clearing heat and cooling blood. It has been used as herbal popular functional food in Asian countries today. Methods In this study, UPLC-Q-TOF-MS was first employed to identify chemical components ethanol extract SR. Then, extraction process optimized using star point design-response surface methodology. Fingerprints different batches processed products...
The purpose of this study was to assess the enhanced physicochemical characteristics, in vitro release behavior, anti-lung cancer activity, gastrointestinal absorption, vivo bioavailability and bioequivalence functional nanoemulsion-hybrid lipid nanocarriers containing diferuloylmethane (DNHLNs). DNHLNs were first fabricated by loading water-in-oil nanoemulsions into hybrid nanosystems using nanoemulsion-thin film-sonication dispersion technologies. situ absorption kinetic features measured...
Abstract The catalytic promiscuity of the novel benzophenone C‐glycosyltransferase, MiCGT, which is involved in biosynthesis mangiferin from Mangifera indica , was explored. MiCGT exhibited a robust capability to regio‐ and stereospecific C‐glycosylation 35 structurally diverse druglike scaffolds simple phenolics with UDP‐glucose, also formed O‐ N‐glycosides. Moreover, able generate C‐xylosides UDP‐xylose. OGT‐reversibility exploited C‐glucosides sugar donor. Three aryl‐C‐glycosides potent...
The utilization of rhizomes from the genus Atractylodes has been challenging due to their closely related origins. In this study, we developed an analytical strategy differentiate lancea (A. lancea), chinensis chinensis), japonica japonica), and macrocephala macrocephala), compared volatile compositions. Gas chromatography-mass spectrometry (GC/MS) was used analyze profiles essential oils extracted 59 batches samples. Chemometric methods enabled a better understanding differences in between...