A5016806253- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Chromatography in Natural Products
- Essential Oils and Antimicrobial Activity
- Berberine and alkaloids research
- Plant-based Medicinal Research
- Flavonoids in Medical Research
- Polysaccharides and Plant Cell Walls
- Ginseng Biological Effects and Applications
- Phytochemicals and Antioxidant Activities
- Immune Cell Function and Interaction
- Spectroscopy and Chemometric Analyses
- Phytochemistry and Bioactive Compounds
- Medicinal plant effects and applications
- Cancer-related Molecular Pathways
- Analytical Chemistry and Chromatography
- PARP inhibition in cancer therapy
- Alkaloids: synthesis and pharmacology
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and biological activity of medicinal plants
- Microbial Metabolism and Applications
- Cancer Mechanisms and Therapy
Tianjin University of Traditional Chinese Medicine
2016-2025
Children's Nutrition Research Center at Baylor College of Medicine
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
Anhui Medical University
2013-2017
Houston Methodist
2017
BioEnergetics (United States)
2017
Cornell University
2017
Anhui Provincial Hospital
2013
University of Science and Technology of China
2011-2012
Abstract Obesity leads to a switch in subsets of CD4 + T cell adipose tissue, characterized by an increase IFNγ producing Th1 cells and decrease anti-inflammatory regulatory (Treg) cells, which impairs systemic insulin sensitivity. What signals these changes is unknown. Herein we demonstrate that genetic deficiency adipocyte MHCII decreases expression increases Treg abundance obese mice, leading reduced obesity-induced inflammation resistance without affecting weight gain. The preserved...
// Yan-Ru Deng 1, * , Wen-Bin Liu 2, Zhe-Xiong Lian 3 Xingsheng Li 4 Xin Hou 5 1 Intensive Care Unit, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China 2 Department Hepatic Surgery and Province Key Laboratory Hepatopancreatobiliary Surgery, Liver Immunology Laboratory, Institute School Life Sciences, University Science Technology China, Gerontology, The Second Chongqing Chongqing, Microbiology Parasitology, Anhui, These authors have contributed equally to this work...
Plantago, also known as plantain, has been used a traditional herb in Asia for centuries to treat urinary tract inflammation and kidney disease. Recently, there increasing interest its potential applications the food industry. In China, are two common species of, namely Plantago asiatica L.(PAL) P. depressa Willd.(PDW), which not distinguished folk clinical practices, leading safety efficacy risks plantago applications. The objective of this study is establish reliable method differentiating...
Mortalin is highly expressed in a variety of human tumors and associated with tumor metastasis. However, the relationship among overexpression Mortalin, epithelial to mesenchymal transition (EMT) neovascularization largely unknown. The aim present study was investigate expression HCC cell lines, clinical specimens its association angiogenesis EMT. results our showed that levels lines higher metastatic potential were significantly compared those lower potential. Compared paracarcinomatous...
Polygoni Multiflori Radix (PMR) is increasingly being used not just as a traditional herbal medicine but also popular functional food. In this study, multivariate chemometric methods and mass spectrometry were combined to analyze the ultra-high-performance liquid chromatograph (UPLC) fingerprints of PMR from six different geographical origins. A strategy based on curve resolution–alternating least squares (MCR–ALS) three classification proposed UPLC obtained. Common chromatographic problems,...
The characteristics of chemical components or groups in traditional Chinese medicines (TCMs) determine their clinical efficacy. Quality markers (Q-markers) is great significance for standardizing the quality control system TCM.We aimed to develop a new strategy discover potential Q-markers TCM by integrating chemometrics, network pharmacology, and molecular docking, using Centipeda minima (also known as ebushicao [EBSC]) an example.First, fingerprints different batches EBSC its counterfeit...
Abstract A new biflavonoid glucoside, apigenin‐7‐ O ‐β‐D‐glucopyranoside‐(3′‐ ‐7″)‐quercetin‐3″‐methyl ether ( 1 ) together with twenty known compounds, apigenin 2 ), luteolin 3 chrysoeriol 4 tricin 5 hispidulin 6 pectolinarigenin 7 eupatilin 8 5,7‐dihydroxy‐6,3′,4′,5′‐tetramethoxyflavone 9 5,7,4′‐trihydroxy‐6,3′,5′‐trimethoxyflavone 10 3,6‐ ‐dimethylquercetagetin‐7‐ ‐β‐D‐glucoside 11 6‐hydroxy‐5,7‐dimethoxy‐coumarin 12 taraxerol 13 taraxeryl acetate 14 a mixture of β‐sitosterol 15 and...
JinQi Jiangtang (JQJT) tablets, a Chinese patent medicine approved by the State Food and Drug Administration, are composed of Coptidis Rhizoma, Astragali Radix, Lonicerae Japonicae Flos, have significant effect on diabetes. Rhizoma is monarch drug in prescription. The aim present study was to investigate compare pharmacokinetics multiple ingredients from JQJT tablets extract (CRE) following oral administration rats. Five alkaloids: coptisine chloride, epiberberine berberine jatrorrhizine...
Two new malic acid derivatives, namely eucomic 1-methyl ester (2) and 6′′′-acetylmilitaline (7), together with ten known compounds (1, 3–6, 8–12), were isolated from the dry tubers of Bletilla striata (Thunb.) Reichb. F., a perennial traditional Chinese medicinal herb, which was used for treatment pneumonophthisis, pneumonorrhagia, tuberculosis, hemorrhage stomach or lung. Their structures elucidated by spectroscopic analyses, including 1D-, 2D-NMR, HR-ESI-MS.
The purpose of this research was to extract and separate the compounds from frankincense, then evaluate their anti-inflammatory effects. isolated compound a representative tetracyclic triterpenes glycine structure according 1H-NMR 13C-NMR spectra, which is β-elemonic acid (β-EA). We determined content six different localities frankincense; average β-EA 41.96 mg/g. toxic effects administration (400, 200, 100 mg/kg) for four weeks in Kunming (KM) mice were observed. Compared with control...
Phenylalanyl-tRNA synthetase (PheRS), a member of aminoacyl-tRNA family, was the new target anti-tubercular drug discovery. In an attempt to fully exploit potential anti-tuberculosis drugs presented in micro-organisms, we developed high-throughput screening assay against Mycobacterium tuberculosis (Mtb) PheRS and then screened library consisting 32,000 strains 1500 natural product-derived compounds. One potent hit extract Penicillium griseofulvum CPCC-400528 identified. this study,...
Abstract In this work, a strategy was proposed to discriminate Polygoni Multiflori Radix (PMR) and its adulterant (Cynanchi Auriculati Radix, CAR). Ultra‐high performance liquid chromatography (UHPLC) fingerprints were established analyze samples containing PMR, CAR mixtures simultaneously. Multivariate classification methods applied the obtained UHPLC fingerprints, including principal component analysis (PCA), partial least square discriminant (PLS‐DA), soft independent modeling of class...
Flavonoids are important active components of traditional Chinese medicines (TCMs) because their many biological activities. We studied the interaction between 17 polysaccharides and eight flavonoids via high-performance liquid chromatography (HPLC) effect interactions on solubility stability flavonoids. The was analyzed by statistical methods showed significant improvements. constant temperature acceleration method (90°C/pH 9 buffer solution) used to measure degradation kinetics half-life...
α-glucosidase inhibitors (AGIs) were commonly used in clinical for the treatment of type 2 diabetes. Xanthones naturally occurring antioxidants, and they may also be potential AGIs. In this study, eleven 1,6- 1,3-substituted xanthone compounds designed synthesized, which four new compounds. Their inhibitory activities vitro silico evaluated. Five with higher activity than acarbose screened out, xanthones substituted at 1,6-positions more likely to non-competitive inhibitors. The binding mode...
The malignancy of breast cancer poses a global challenge, with existing treatments often falling short desired efficacy. Extensive research has underscored the effectiveness targeting metabolism nicotinamide adenine dinucleotide (NAD), pivotal molecule crucial for cell survival and growth, as promising anticancer strategy. Within mammalian cells, sustaining optimal NAD concentrations relies on two key enzymes, namely phosphoribosyltransferase (NAMPT) poly(ADP-ribose) polymer 1 (PARP1)....