A5002278733- Phytochemical Studies and Bioactivities
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Phytochemicals and Antioxidant Activities
- Polysaccharides and Plant Cell Walls
- Cancer-related gene regulation
- Aquaculture disease management and microbiota
- Eicosanoids and Hypertension Pharmacology
- Plant-based Medicinal Research
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Fungal Biology and Applications
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Marine Sponges and Natural Products
- Traditional Chinese Medicine Analysis
- Protein Degradation and Inhibitors
- Berberine and alkaloids research
- Reproductive Biology and Fertility
- Medicinal Plants and Neuroprotection
- Potato Plant Research
Nanjing Medical University
2014-2025
Nanjing Jiangning Hospital
2020-2025
Heilongjiang University of Chinese Medicine
2020-2025
Wuhan Polytechnic University
2025
China Agricultural University
2020-2025
East China Normal University
2023-2024
Aviation General Hospital
2024
China Medical University
2024
Fudan University
2024
State Key Laboratory of Surface Physics
2024
Although changes in gut microbiome have been associated with the development of T2D and its complications, role virome remains largely unknown. Here, we characterized alterations complications diabetic nephropathy (DN) by metagenomic sequencing fecal viral-like particles. Compared controls, subjects, especially those DN, had significantly lower viral richness diversity. 81 species were identified to be altered including a decrease some phages (e.g. Flavobacterium phage Cellulophaga phaga)....
Abstract To bolster the capacity for managing potential infectious diseases in future, it is critical to develop specific antiviral drugs that can be rapidly designed and delivered precisely. Herein, a CRISPR/Cas13d system broad‐spectrum targeting of influenza A virus (IAV) from human, avian, swine sources designed, incorporating Cas13d mRNA tandem CRISPR RNA (crRNA) highly conserved regions viral polymerase acidic (PA), nucleoprotein (NP), matrix (M) gene segments, respectively. Given...
The de-regulation of the miR-29 family and DNA methyltransferase 3A (DNMT3A) is associated with gastric cancer (GC). While increasing evidence indicates miR-29b/c could regulate methylation by targeting DNMT3A, it currently unknown if epigenetic silencing via promoter hypermethylation in GC caused abnormal expression DNMT3A. Thus, we aimed to evaluate whether cross-talk regulation exists between DNMT3A a malignant phenotype GC. First, wound healing Transwell assays revealed that suppresses...
DNA methyltransferase 3A (DNMT3A) has been recognised as a key element of epigenetic regulation in normal development, and the aberrant DNMT3A is implicated multiple types cancers, especially haematological malignancies. However, its clinical significance detailed functional role solid tumours remain unknown, although abnormal expression gained widespread attention these cancers. Here, we show that isoform b (DNMT3Ab), member family, critical for directing epithelial–mesenchymal transition...
Mild hypothermia has been proven to inhibit microglia activation after TBI. Exosomal microRNA derived from played a critical role in promoting neurite outgrowth and synapse recovery. Here, we aimed investigate the of microRNAs microglial exosomes treatment on neuronal regeneration For vitro study, stretch-injured neurons were co-cultured with exosomes. vivo C57BL/6 mice under controlled cortical impact injected The results showed that MG-LPS-EXOHT increased number dendrite branches total...
Abstract Contents of total flavonoids, phenolics, triterpenes, condensed tannin and saponins in peels, flesh endocarps Chaenomeles speciosa (CSP) sinensis (CSS) were determined by colorimetric method, while 5 phenolics (vanillic, gallic, chlorogenic, ferulic p ‐coumaric acids), 2 triterpenes (oleanolic ursolic 3 flavonoids (rutin, catechin epicatechin) identified quantified high‐performance liquid chromatography‐mass spectrometry (HPLC‐MS) HPLC, antioxidant α‐glucosidase inhibitory...
Traumatic brain injury (TBI) causes a primary insult and initiates secondary cascade. The mechanisms underlying the are multifactorial may include aberrant expression of long non-coding RNA (lncRNA) post-TBI. Here, lncRNA microarray analysis was performed to profile altered lncRNAs in rat hippocampus after TBI. A total 271 probe sets 1046 messenger (mRNA) were differentially expressed Gene ontology showed that main components most significantly changed categories inflammation, DNA...
Abstract Background Hesperidin, a natural flavanone, has been proven to have multiple protective effects in diabetic rats, such as antioxidant, anti-inflammatory and anti-apoptotic effects. However, the molecular mechanisms underlying of hesperidin are not well elucidated. Methods LO2 cells were stimulated with high glucose (HG, 33 mM) for 24 h establish model oxidative stress. Then, cell viability was determined using MTT assay. The antioxidant activities, including reactive oxygen species...
High-precision atomic spectroscopy provides an invaluable and sensitive tool for exploring a wide range of physical questions. Here, we investigate the forbidden optical transition <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"...
Abstract Squamous intraepithelial lesion of cervix (SIL) in human papillomavirus (HPV)-positive patient often undergoes a silent and long-course development, most them with high-grade transit to cervical squamous cell carcinoma (CSCC). The oxysterol 25-hydroxycholesterol (25-HC) is associated HPV inhibition, autophagy cholesterol synthesis, however, its function this long process SIL development remain unclear. In study, we demonstrate that 25-HC generation inhibited through HSIL-to-CSCC...