A5100347261- Natural product bioactivities and synthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Phytochemistry and Bioactivity Studies
- Traditional Chinese Medicine Analysis
- Chemical synthesis and alkaloids
- Toxic Organic Pollutants Impact
- Biological Activity of Diterpenoids and Biflavonoids
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Bioactive Compounds
- Chromatography in Natural Products
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Synthetic Organic Chemistry Methods
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Crystallography and molecular interactions
- Phytochemicals and Antioxidant Activities
Jinan University
2016-2025
Chinese Academy of Tropical Agricultural Sciences
2013-2025
University of Shanghai for Science and Technology
2025
First Affiliated Hospital of Jinan University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Shanghai Sixth People's Hospital
2020-2025
Southern Medical University
2013-2025
Shanxi Agricultural University
2022-2025
National Institutes for Food and Drug Control
2016-2025
Tianjin Medical University General Hospital
2013-2025
The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on biologic understanding leprosy. Host genetic factors are thought influence susceptibility infection as well disease progression.We performed a two-stage genomewide association study by genotyping 706 patients 1225 controls using Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an between presence leprosy 93 single-nucleotide...
Abstract We demonstrate that the 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors atorvastatin and simvastatin enhance functional outcome induce brain plasticity when administered after stroke to rats. With treatment initiated 1 day stroke, animals exhibited significant increases in vascular endothelial growth factor, cyclic guanosine monophosphate, angiogenesis, endogenous cell proliferation neurogenesis, an increase synaptic protein, synaptophysin. Atorvastatin‐induced...
The hypoxia-inducible factor-1alpha (HIF-1alpha) pathway is the central regulator of adaptive responses to low oxygen availability and required for normal skeletal development. Here, we demonstrate that HIF-1alpha activated during bone repair can be manipulated genetically pharmacologically improve healing. Mice lacking pVHL in osteoblasts with constitutive activation had markedly increased vascularity produced more response distraction osteogenesis, whereas mice impaired angiogenesis...
The overall goal of this paper was to develop poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) curcumin (CUR), named CUR-PLGA-NPs, and study the effect mechanisms enhancing oral bioavailability CUR. CUR-PLGA-NPs were prepared according a solid-in-oil-in-water (s/o/w) solvent evaporation method exhibited smooth spherical shape with diameters about 200 nm. Characterization showed CUR successfully encapsulated on PLGA polymer. entrapment efficiency loading rate 91.96 5.75%, respectively....
Abstract Thymoquinone, a component derived from the medial plant Nigella sativa, has been used for medical purposes more than 2,000 years. Recent studies reported that thymoquinone exhibited inhibitory effects on cell proliferation of many cancer lines and hormone-refractory prostate by suppressing androgen receptor E2F-1. Whether inhibits tumor angiogenesis, critical step growth metastasis, is still unknown. In this study, we found effectively inhibited human umbilical vein endothelial...
Copper (Cu) is essential for many biological processes, but toxic when present in excessive amounts. In this study, we provide evidence that Cu plays a crucial role controlling tuberculosis. A Mycobacterium tuberculosis ( Mtb ) mutant lacking the outer membrane channel protein Rv1698 accumulated 100-fold more and was susceptible to toxicity than WT . Similar phenotypes were observed M. smegmatis homolog Ms3747, demonstrating these mycobacterial copper transport proteins B (MctB) are...
Class IA phosphatidylinositol 3-kinases (PI3K), which generate PIP3 as a signal for cell growth and proliferation, exist an intracellular complex of catalytic subunit bound to regulatory subunit. We others have previously reported that heterozygous mutations in PIK3CD encoding the p110δ PI3K cause unique disorder termed p110δ-activating causing senescent T cells, lymphadenopathy, immunodeficiency (PASLI) disease. report four patients from three families with similar disease who harbor...
BackgroundWuhan was the epicentre of COVID-19 outbreak in China. We aimed to determine seroprevalence and kinetics anti-SARS-CoV-2 antibodies at population level Wuhan inform development vaccination strategies.MethodsIn this longitudinal cross-sectional study, we used a multistage, population-stratified, cluster random sampling method systematically select 100 communities from 13 districts Wuhan. Households were selected each community all family members invited health-care centres...
Abstract Human induced pluripotent stem cells (iPSCs) and genome editing provide a precise way to generate gene-corrected for disease modeling cell therapies. iPSCs generated from sickle (SCD) patients have homozygous missense point mutation in the HBB gene encoding adult β-globin proteins, are used as model system improve strategies of human therapy. We demonstrate that CRISPR/Cas9 designer nuclease is much more efficient stimulating targeting endogenous locus near SCD than zinc finger...
Successfully combating the COVID-19 pandemic depends on mass vaccination with suitable vaccines to achieve herd immunity. Here, we describe COVI-VAC, only live attenuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine currently in clinical development. COVI-VAC was developed by recoding a segment of viral spike protein synonymous suboptimal codon pairs (codon-pair deoptimization), thereby introducing 283 silent (point) mutations. In addition, furin cleavage site within...
Redox imbalance is an vital mechanism for COPD. At present, insufficient researches have been conducted on the protective effect of hydrogen sulfide (H2S) PM-induced However, whether H2S exerts anti-injury role by blocking ferroptosis and restoring redox equilibrium remain to be investigated. Human lung tissue samples were collected IHC staining, expressions Nrf2, ferritinophagy- ferroptosis-related proteins observed. The WT C57BL/6 Nrf2 knockout mice models established with PM(200 μg per...
Vaccination against SARS-CoV-2 provides an effective tool to combat the COVID-19 pandemic. Here, we combined antigen optimization and nanoparticle display develop vaccine candidates for SARS-CoV-2. We first displayed receptor-binding domain (RBD) on three self-assembling protein (SApNP) platforms using SpyTag/SpyCatcher system. then identified heptad repeat 2 (HR2) in S2 as cause of spike metastability, designed HR2-deleted glycine-capped (S2GΔHR2), S2GΔHR2 SApNPs. An antibody column...
Natural selection acts on variation within populations, resulting in modified organ morphology, physiology, and ultimately the formation of new species. Although orthologous proteins can contribute to these modifications, differences DNA sequences regulating gene expression may be a primary source variation. We replaced limb-specific transcriptional enhancer mouse Prx1 locus with sequence from bat. directed by bat results elevated transcript levels developing forelimb bones forelimbs that...
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder accompanied with an increased risk of developing type 2 diabetes mellitus and cardiovascular disease; despite being common condition, the pathogenesis PCOS remains unclear. Our aim was to investigate potential metabolic profiles for different phenotypes PCOS, as well early prognosis complications.A total 217 women 48 healthy normal controls were studied. Plasma samples subjects tested using two analytical platforms...
Secondary metabolites are usually the bioactive components of medicinal plants. The difference in secondary metabolisms closely related plant species and their hybrids has rarely been addressed. In this study, we conducted a holistic metabolomics analysis three Glycyrrhiza (G. uralensis, G. glabra, inflata), which used as popular herbal medicine licorice. (genotype) for 95 batches samples were identified by DNA barcodes internal transcribed spacer trnV-ndhC regions, chemotypes revealed...
Objective. To evaluate the benefits of conditioned medium Adipose-derived stem cells (ADSC-CM) on wound healing after fractional carbon dioxide laser resurfacing (FxCR) human skin. Materials and Methods. Nineteen subjects were treated with FxCR bilateral inner arms. ADSC-CM was applied site one randomly selected arm. Transepidermal water loss (TEWL), skin color, gross-elasticity both arms measured. Skin samples taken by biopsy from three 3 weeks treatment for histopathological manifestations...