Shunyi Wang
A5101516760- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Retinal and Optic Conditions
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- Reproductive System and Pregnancy
- SARS-CoV-2 detection and testing
- Cancer Immunotherapy and Biomarkers
- Polyoxometalates: Synthesis and Applications
- COVID-19 diagnosis using AI
- Cancer-related molecular mechanisms research
- Bioactive natural compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Nanomaterials in Catalysis
- Immune cells in cancer
- Maternal Mental Health During Pregnancy and Postpartum
- NF-κB Signaling Pathways
- Renal cell carcinoma treatment
- interferon and immune responses
- Intensive Care Unit Cognitive Disorders
- Renal and related cancers
Southern Medical University
2024
Nanfang Hospital
2024
Guangdong Pharmaceutical University
2021-2024
Institute of Laboratory Animal Science
2019-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Baoding People's Hospital
2016-2021
Baoding No.1 Central Hospital
2021
Peking Union Medical College Hospital
2019
Beijing University of Technology
2016-2017
Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It unclear whether convalescing patients have risk of reinfection. We generated rhesus macaque model SARS-CoV-2 that was characterized interstitial pneumonia and systemic viral dissemination mainly in gastrointestinal tracts. Rhesus macaques reinfected identical strain during early recovery phase initial did not show detectable...
Abstract A global pandemic of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is ongoing spread. It remains unclear whether the convalescing patients have a risk reinfection. Rhesus macaques were rechallenged with SARS-CoV-2 during an early recovery phase from initial infection characterized weight loss, interstitial pneumonia and systemic viral dissemination mainly in gastrointestinal tracts. The monkeys identical strain failed to produce...
Abstract Background Since December 2019, an outbreak of the Corona Virus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) in Wuhan, China, has become a public health emergency international concern. The high fatality aged cases SARS‐CoV‐2 was need to explore possible age‐related phenomena with non‐human primate models. Methods Three 3‐5 years old and two 15 rhesus macaques were intratracheally infected SARS‐CoV‐2, then analyzed clinical signs,...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmitted through the route, but potential extra-respiratory routes of SARS-CoV-2 transmission remain uncertain. Here we inoculated five rhesus macaques with 1 × 10 6 TCID 50 conjunctivally (CJ), intratracheally (IT), and intragastrically (IG). Nasal throat swabs collected from CJ IT had detectable viral RNA at 1–7 days post-inoculation (dpi). Viral was detected in anal only group dpi. undetectable tested...
Abstract Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the Corona Virus Disease 2019 (COVID-19) cases in China has become a public health emergency of international concern (PHEIC). Based on angiotensin converting enzyme 2 (ACE2) as cell entry receptor SARS-CoV, we used hACE2 transgenic mice infected with SARS-CoV-2 to study pathogenicity virus. Weight loss and virus replication lung were observed SARS-CoV-2. The typical histopathology was interstitial pneumonia infiltration...
Abstract Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, influence of these viruses on disease outcome when both influenza and are present in host remains unclear. Using a mammalian model, sequential infection was performed ferrets K18- hACE2 mice, following H1N1. We found that co-infection H1N1 extended duration clinical manifestation COVID-19, enhanced pulmonary damage, but reduced viral...
We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme (hACE2) mice via close contact because 7 of 13 hACE2 were SARS-CoV-2 antibody seropositive 14 days after being introduced into same cage with infected-hACE2 mice. For droplets, antibodies from 10 showed seropositivity introduction mice, separated by...
Abstract The outbreak of Corona Virus Disease 2019 caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) is highly transmitted. potential extra-respiratory transmission routes remain uncertain. Five rhesus macaques were inoculated with 1×10 6 TCID 50 SARS-CoV-2 via conjunctival (CJ), intratracheal (IT), and intragastric (IG) routes, respectively. Remarkably, CJ inoculated-macaques developed mild interstitial pneumonia viral load was detectable in swabs at 1 days...
Abstract Background Adenoma-adenocarcinoma transition is a key feature of colorectal cancer (CRC) occurrence and closely regulated by tumor-associated macrophages (TAMs) CD8 + T cells. Here, we investigated the effect NF-κB activator 1 (Act1) downregulation in adenoma-adenocarcinoma transition. Methods This study used spontaneous adenoma-developing Apc Min/+ , macrophage-specific Act1-knockdown (anti-Act1), ; anti-Act1 (AA) mice. Histological analysis was performed on CRC tissues patients...
Aloperine is an alkaloid that exerts significant inhibitive effects on acute inflammation and Type Ⅲ Ⅳ hypersensitivity caused by a variety of inflammatory agents. The aims the present study were to investigate whether protective effect aloperine attenuates hydrogen peroxide (H2O2)‑induced injury, identify underlying mechanisms involved. Nucleus pulposus cells extracted from adult male Sprague‑Dawley rats, incubated with fresh medium containing 200 µM H2O2 for 24 h. In study, treatment...
Viral pneumonitis caused by influenza A (H1N1) virus leads to high levels of morbidity and mortality. Given the limited treatment options for severe pneumonia, it is necessary explore effective amelioration approaches. IL-37 has been reported inhibit excessive immune responses protect against a variety inflammatory diseases. In this study, using BALB/c mice intranasally infected with A/California/07/2009 (H1N1), we found that increases survival rate body weight, reduces pulmonary index,...
Aim: Although studies on lncRNAs in renal fibrosis have focused target genes and functions of lncRNAs, a comprehensive interaction analysis is lacking. Materials & methods: Differentially expressed were screened, the between miRNAs was searched. Results: We constructed ceRNA network associated with fibrosis, by which we found transcription factor Creb5, gene lncRNA Gas5 that might regulate extracellular Fn1 deposition. Conclusion: Our study not only provides theoretical basis for regulation...
The mass inoculation of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine to induce herd immunity is one the most effective measures fight COVID-19. vaccination pregnant women cannot only avoid or reduce probability infectious diseases, but also offers and direct protection for neonates by means passive immunization. However, there no randomized clinical data ascertain whether inactivated childbearing age can affect conception fetus. We found that human...
A Correction to this paper has been published: https://doi.org/10.1007/s00125-020-03108-4.
Atrial natriuretic peptide (ANP) activity deficiency contributes to salt-sensitive hypertension in humans and mice. However, the role of ileal microbiota salt sensitivity ANP deficiency-related cardiac injury has not been investigated yet. This study used ANP−/− mice analyze microbiome on injury. showed an increase blood pressure (BP), heart weight/body weight (HW/BW) ratio, hypertrophy compared with wild-type (WT) did impact histological structure but reduced occludin expression ileum....
To our knowledge, the periprosthetic joint infection (PJI) caused by Mycoplasma hominis is a rare postoperative complication after total knee arthroplasty (TKA). Just few cases associated with TKA were reported all over world currently. In view of difficulty involved in isolating this microorganism, may be under-recognized and should considered culture-negative where microbial etiology not easily identified. Metagenomic sequencing new tool to identify pathogens undetected conventional...
After a series of studies on the pathogenicity several H7N9 strains from 2013 to 2018, we wanted dynamically track A/Guangdong/Th005/2017 in ferrets and poultry. The transmissibility Th005, especially distribution replication tissues, were studied ferrets. We also aimed assess level Th005 chickens. results showed that was significantly increased chickens, compared with Anhui strain. lung tissues 100-fold higher than reached an intravenous index (IVPI) score 3 avian models. Continuously high...