A5084693085- Autophagy in Disease and Therapy
- Bacterial biofilms and quorum sensing
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- DNA Repair Mechanisms
- Asthma and respiratory diseases
- Respiratory viral infections research
- RNA Interference and Gene Delivery
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Effects and risks of endocrine disrupting chemicals
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Selenium in Biological Systems
- Plant Gene Expression Analysis
University of Chinese Academy of Sciences
2018-2025
Wenzhou Medical University
2024-2025
Chinese Academy of Sciences
2013-2025
Nanchang University
2025
East China Normal University
2025
Changzhou Institute of Technology
2025
First Affiliated Hospital of Wenzhou Medical University
2025
University of North Dakota
2015-2024
Soochow University
2013-2024
Anhui Agricultural University
2015-2024
A facile bottom-up method for the synthesis of highly fluorescent graphene quantum dots (GQDs) has been developed using a one-step pyrolysis natural amino acid, L-glutamic with assistance simple heating mantle device. The GQDs showed strong blue, green and red luminescence under irradiation ultra-violet, blue light, respectively. Moreover, emitted near-infrared (NIR) fluorescence in range 800-850 nm excitation-dependent manner. This NIR large Stokes shift 455 nm, providing significant...
Polymyxins remain the last line treatment for multidrug-resistant (MDR) infections. As polymyxins resistance emerges, there is an urgent need to develop effective antimicrobial agents capable of mitigating MDR. Here, we report biodegradable guanidinium-functionalized polycarbonates with a distinctive mechanism that does not induce drug resistance. Unlike conventional antibiotics, repeated use polymers lead Transcriptomic analysis bacteria further supports development antibiotics but...
Nanocarriers with positive surface charges are known for their toxicity which has limited clinical applications. The mechanism underlying toxicity, such as the induction of inflammatory response, remains largely unknown. In present study we found that injection cationic nanocarriers, including liposomes, PEI, and chitosan, led to rapid appearance necrotic cells. Cell necrosis induced by nanocarriers is dependent on charges, but does not require RIP1 Mlkl. Instead, intracellular Na+ overload...
Abstract Background Males and females differ in their immunological responses to foreign pathogens. However, most of the current COVID-19 clinical practices trials do not take sex factor into consideration. Methods We performed a sex-based comparative analysis for outcomes, peripheral immune cells, severe acute respiratory syndrome coronavirus (SARS-CoV-2) specific antibody levels 1558 males 1499 patients from single center. The lymphocyte subgroups were measured by Flow cytometry. total...
BACKGROUND. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 1 million deaths worldwide; thus, there is an urgent need to develop preventive and therapeutic strategies. The antituberculosis vaccine bacillus Calmette-Guérin (BCG) demonstrates nonspecific, protective innate immune–boosting effects. Here, we determined whether a history of BCG vaccination was associated with decreased SARS-CoV-2 infection seroconversion in longitudinal, retrospective...
Luminescent nanomaterials can provide high-intensity and photostable luminescent signals when used as labeling materials for the determination of trace amounts analytes. However, a major concern that has arisen is whether cause toxic effects in living systems. Here, we address this problem through systematic investigation cytotoxicity genotoxicity silica nanoparticles. These nanoparticles are intensely ultrasensitive biological samples. The was carried out from two perspectives. First,...
Abstract Background Our understanding of the eukaryotic tree life and tremendous diversity microbial eukaryotes is in flux as additional genes diverse taxa are sampled for molecular analyses. Despite instability many analyses, there an increasing trend to classify into six major supergroups: 'Amoebozoa', 'Chromalveolata', 'Excavata', 'Opisthokonta', 'Plantae', 'Rhizaria'. Previous analyses have often suffered from either a broad taxon sampling using only single-gene data or used multigene...
Intracellular bacteria have been shown to cause autophagy, which impacts infectious outcomes, whereas extracellular not reported activate autophagy. Here, we demonstrate that Pseudomonas aeruginosa, a Gram-negative bacterium, activates autophagy with considerably increased LC3 punctation in both an alveolar macrophage cell line (MH-S) and primary macrophages. Using the Gly120 mutant, successfully demonstrated hallmark of conjugation phosphatidylethanolamine (PE). The accumulation typical...
Pathogenic bacteria cause various infections worldwide, especially in immunocompromised and other susceptible individuals, are also associated with high infant mortality rates developing countries. MicroRNAs (miRNAs), small non-coding RNAs evolutionarily conserved sequences, expressed tissues cells that play key part physiological pathologic processes. Increasing evidence implies roles for miRNAs bacterial infectious diseases by modulating inflammatory responses, cell penetration, tissue...
Sepsis is a severe and complicated syndrome that characterized by dysregulation of host inflammatory responses organ failure, with high morbidity mortality. The literature implies autophagy crucial regulator inflammation in sepsis. In this article, we report autophagy-related protein 7 (Atg7) involved inflammasome activation Pseudomonas aeruginosa abdominal infection. Following i.p. challenge P. aeruginosa, atg7fl/fl mice showed impaired pathogen clearance, decreased survival, widespread...
Abstract Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive lung remains poorly understood. In this study, we verified that FRβ overexpression TAMs was associated with poor prognosis. We utilized a folate-modified lipoplex comprising liposome (F-PLP) delivering BIM-S plasmid to...
Bleomycin is a clinically potent anticancer drug used for the treatment of germ-cell tumors, lymphomas and squamous-cell carcinomas. Unfortunately, therapeutic efficacy bleomycin severely hampered by development pulmonary fibrosis. However, mechanisms underlying bleomycin-induced fibrosis, particularly molecular target bleomycin, remains unknown. Here, using chemical proteomics approach, we identify ANXA2 (annexin A2) as direct binding bleomycin. The interaction with was corroborated both in...
Despite extensive research, the pathogenesis of cigarette smoking (CS)-associated emphysema remains incompletely understood, thereby impeding development novel therapeutics, diagnostics, and biomarkers. Here, we report a paradigm potentially involved in epithelial death tissue loss CS-associated emphysema. After prolonged exposure CS, CCN1 cleavage was detected both vitro vivo. Full-length (flCCN1) secreted an exosome-shuttled manner, plasmin converted flCCN1 to cleaved (cCCN1) extracellular...