A5001547268- Surface Modification and Superhydrophobicity
- Circular RNAs in diseases
- Advanced Sensor and Energy Harvesting Materials
- Biosensors and Analytical Detection
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Bioinformatics and Genomic Networks
- CAR-T cell therapy research
- Long-Term Effects of COVID-19
- Luminescence and Fluorescent Materials
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Nanofabrication and Lithography Techniques
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Gene expression and cancer classification
- RNA modifications and cancer
- QR Code Applications and Technologies
- Cancer Immunotherapy and Biomarkers
- Advanced Graph Neural Networks
- Fluid Dynamics and Thin Films
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
Queen's University
2022-2025
Sichuan University
2024-2025
West China Hospital of Sichuan University
2025
Central South University
2017-2024
Nanjing Medical University
2020-2024
Jiujiang University
2023
Jiangsu Cancer Hospital
2022
Simon Fraser University
2017-2021
Center for Global Health
2020
Burnaby Hospital
2019
Superhydrophobic coatings have tremendous potential for applications in different fields and been achieved commonly by increasing nanoscale roughness lowering surface tension. Limited the availability of either ideal nano-structural templates or simple fabrication procedures, search superhydrophobic that are easy to manufacture robust real-life remains challenging both academia industry. Herein, we report an unconventional protocol based on a single-step, stoichiometrically controlled...
Abstract Background Males and females differ in their immunological responses to foreign pathogens. However, most of the current COVID-19 clinical practices trials do not take sex factor into consideration. Methods We performed a sex-based comparative analysis for outcomes, peripheral immune cells, severe acute respiratory syndrome coronavirus (SARS-CoV-2) specific antibody levels 1558 males 1499 patients from single center. The lymphocyte subgroups were measured by Flow cytometry. total...
Abstract Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and closely related to occurrence development of nasopharyngeal carcinoma (NPC), gastric (GC), several lymphomas. PD-L1 expression elevated in EBV-positive NPC GC tissues; however, specific mechanisms underlying EBV-dependent promotion induce immune escape warrant clarification. EBV encodes 44 mature miRNAs. In this study, we find that EBV-miR-BART11 EBV-miR-BART17-3p upregulate EBV-associated GC....
Selective and fast: A flavylium derivative-based ratiometric fluorescent probe (1) for H2S is reported. The reaction mechanism (see scheme) based on the nucleophilic addition of towards electrically positive benzopyrylium moiety 1, which can efficiently differentiate from other competitive species. exhibits a fast response toward H2S, within 10 s, superior to most reported probes.
Abstract Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-cell RNA sequencing (scRNA-seq), we dissected cellular states bone marrow samples from primary refractory or short-term relapsed AML patients defined transcriptional intratumoral heterogeneity. We found that compared to proliferating stem/progenitor-like cells (PSPs), a subpopulation quiescent stem-like (QSCs) were involved in chemoresistance poor outcomes AML. By performing longitudinal...
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor tissues of six MBC thirteen female (FBC) patients. We find has significantly lower infiltration T relative to FBC. Metastasis-related programs are more active in MBC. The activated fatty acid metabolism involved FASN related cell metastasis low immune show activation p38 MAPK lipid...
Cutaneous T cell lymphoma (CTCL) is characterized by the accumulation of malignant cells in skin. However, advanced CTCL pathophysiology remains elusive and therapeutic options are limited due to high intratumoral heterogeneity complicated tumor microenvironment (TME). By comparing single-cell RNA-seq (scRNA-seq) data from patients healthy controls (HCs), we showed that had a higher enrichment T/NK myeloid cells. Subpopulations (CXCR3
Off-the-shelf laboratory filter paper of different pore sizes and thicknesses can be modified with fluorine-free organosilanes to superhydrophobic, patternable, ready for quantitative assay applications. In particular, we have demonstrated that the cellulose treated a binary hexane solution short (methyltrichlorosilane) long (octadecyltrichlorosilane) exhibits remarkably high water contact angles (>150°) low wetting hysteresis (∼10°). Beyond optimized ratio between two organosilanes,...
Abstract Motivation Many studies have shown that microRNAs (miRNAs) play a key role in human diseases. Meanwhile, traditional experimental methods for miRNA–disease association identification are extremely costly, time-consuming and challenging. Therefore, many computational been developed to predict potential associations between miRNAs However, those mainly the existence of associations, they cannot deep-level types. Results In this study, we propose new end-to-end deep learning method...
Abstract Given recent interest in laboratory automation and miniaturization, the microdroplet research space has expanded across disciplines sectors. In turn, field is continually evolving seeking new methods to generate microdroplets, especially ways that can be integrated into diverse (microfluidic) workflows. Herein, we present a convenient, low‐cost, re‐usable generation device, termed as “NanoWand,” which enables formation nanoliter volume range through modulated surface energy...
The human papillomavirus (HPV) is implicated in multiple lethal cancers, although it more sensitive to certain therapies than HPV-negative cancers. Therefore, the development of targeted therapeutic strategies imperative. HPV oncogenes E6/E7 are ideal targets for HPV-positive cancer, but there no clinical that have been proven effectively target E6/E7. Notably, metformin significantly inhibits expression; however, underlying mechanism and potential remain unclear, limiting its translation....
Cotton fabrics are functionalized with a binary solution of fluorine-free organosilanes and "encapsulated" silver nanoparticles to achieve both superhydrophobic antimicrobial properties. Derived from cellulose, cotton is one the most abundant biologically generated materials has been used in wide variety consumer goods. Nonetheless, not waterproof prone microbial contamination. Herein we report rapid functionalization hexane methyltrichlorosilane (MTS) octadecyltrichlorosilane (OTS) at low...
We have discovered herein that commonly used laboratory glass microfiber filters can be functionalized as background-free superhydrophobic substrates for quantitative fluorometric assays. In particular, (Whatman GF/A) treated with low-concentration (20 mM) methyltrichlorosilane/toluene solution to (water contact angle >150°) in less than 5 min; the modified filter readily patterned UV/ozone irradiation create hydrophilic reaction zones on otherwise substrate. Compared traditional cellulose...
WRKY transcription factors (TFs), which are plant-specific TFs, play significant roles in plant defense. Here, a pathogen-induced gene, named AktWRKY12, was the homologous gene of AtWRKY12, isolated from Akebia trifoliata. The AktWRKY12 has total length 645 nucleotides and an open reading frame (ORF) encoding 214 amino acid polypeptides. characterizations were subsequently performed with ExPASy online tool Compute pI/Mw, PSIPRED SWISS-MODEL softwares. could be classified as member group II-c...
Abstract Motivation Identifying cancer genes remains a significant challenge in genomics research. Annotated gene sets encode functional associations among multiple genes, and have been shown to cluster hallmark signaling pathways biological processes. The knowledge of annotated is critical for discovering but be fully exploited. Results Here, we present the DIsease-Specific Hypergraph neural network (DISHyper), hypergraph-based computational method that integrates from types predict genes....
Electronic textiles with remarkable breathability, lightweight, and comfort hold great potential in wearable technologies smart human-machine interfaces. Ionic capacitive sensors, leveraging the advantages of electric double layer, offer higher sensitivity compared to traditional sensors. Current research on ion-capacitive sensors has focused mainly two-dimensional (2D) or three-dimensional (3D) device architectures, which show substantial challenges for direct integration compromise their...
Circular RNAs (circRNAs) are reverse-spliced and covalently closed RNAs. Their interactions with RNA-binding proteins (RBPs) have multiple effects on the progress of many diseases. Some computational methods proposed to identify RBP binding sites circRNAs but suffer from insufficient accuracy, robustness explanation. In this study, we first take characteristics both RNA into consideration. We propose a method for discriminating circRNA-RBP based multi-scale characterizing sequence structure...