A5100369487- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Renal and related cancers
- Genomics and Chromatin Dynamics
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Head and Neck Cancer Studies
- Diabetes Treatment and Management
- Irrigation Practices and Water Management
- Immunotherapy and Immune Responses
Southern University of Science and Technology
2025
Sichuan University
2015-2025
First Affiliated Hospital of GuangXi Medical University
2022-2025
Guangxi Medical University
2022-2025
Children's Hospital of Fudan University
2020-2025
University of Chinese Academy of Sciences
2025
Second Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
University of New Haven
2025
Yale University
2025
The CHOICE-01 study investigated the efficacy and safety of toripalimab in combination with chemotherapy as a first-line treatment for advanced non-small-cell lung cancer (NSCLC).Patients (N = 465) treatment-naive, NSCLC without EGFR/ALK mutations were randomly assigned 2:1 to receive 240 mg (n 309) or placebo 156) once every 3 weeks 4-6 cycles, followed by maintenance plus standard care. Stratification factors included programmed death ligand-1 expression status, histology, smoking status....
Emerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although genomic and transcriptomic aberrations correlate with plasticity, the molecular mechanisms enabling acquisition of plasticity have not been fully elucidated. We reveal Janus kinase (JAK)-signal transducer activator transcription (STAT) signaling is a crucial executor in promoting plasticity-driven androgen receptor (AR)-targeted therapy prostate cancer....
Importance For patients with non–small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited. Objective To compare the efficacy of ivonescimab plus chemotherapy alone for relapsed advanced or metastatic epidermal growth factor receptor ( ) variant. Design, Setting, and Participants Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China...
Metastatic prostate cancer is characterized by recurrent genomic copy number alterations that are presumed to contribute resistance hormone therapy. We identified CHD1 loss as a cause of antiandrogen in an vivo small hairpin RNA (shRNA) screen 730 genes deleted cancer. ATAC-seq and RNA-seq analyses showed resulted global changes open closed chromatin with associated transcriptomic changes. Integrative analysis this data, together CRISPR-based functional screening, four transcription factors...
Abstract Background Circular RNAs (circRNAs) are widely expressed in human cells and closely associated with cancer development. However, they have rarely been investigated the context of nasopharyngeal carcinoma (NPC). Methods We screened a new circRNA, circRNF13 , NPC using next-generation sequencing mRNA. Reverse transcription polymerase chain reaction RNA fluorescence situ hybridization were used to detect expression 12 non-tumor epithelial (NPE) tissues 36 samples. Cell proliferation...
YAP confers small cell lung cancer with the intratumoral heterogeneity and resistance to chemotherapy drugs.
Background Pyroptosis is a lytic cell death form executed by gasdermins family proteins. Induction of tumor pyroptosis promotes anti-tumor immunity and potential cancer treatment strategy. Triptolide (TPL) natural product isolated from the traditional Chinese herb which possesses potent activity in human cancers. However, its role remains to be elucidated. Methods Cell survival was measured colony formation assay. apoptosis determined Annexin V evaluated morphological features release...
Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i's) were shown reduce hospitalization and stress. However, how inflammation causes cells, SGLT2i's can this is unknown. Here we hypothesized that 1) TNF-α activates the Na+/H+ exchanger (NHE) raises cytoplasmatic Na+ ([Na+]c), 2) increased [Na+]c reactive oxygen species (ROS) production, 3) empagliflozin (EMPA) reduces inflammation-induced ROS...