A5101757920- Acute Kidney Injury Research
- Acute Myocardial Infarction Research
- Chronic Kidney Disease and Diabetes
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Parathyroid Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Renal and Vascular Pathologies
- Prostate Cancer Treatment and Research
- Monoclonal and Polyclonal Antibodies Research
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Pharmaceutical and Antibiotic Environmental Impacts
- Immunotherapy and Immune Responses
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Wastewater Treatment and Nitrogen Removal
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Antibiotic Resistance in Bacteria
- Medical Imaging and Pathology Studies
- Venous Thromboembolism Diagnosis and Management
Daye People's Hospital
2014-2025
Tongji Hospital
2025
First Affiliated Hospital of Jinan University
2023-2025
Zhejiang Pharmaceutical College
2025
Guangzhou University of Chinese Medicine
2024
The University of Texas Southwestern Medical Center
2006-2023
Southwestern Medical Center
2006-2023
Hubei Zhongshan Hospital
2020-2023
Wuhan University
2020-2023
China Medical University
2022-2023
Emerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although genomic and transcriptomic aberrations correlate with plasticity, the molecular mechanisms enabling acquisition of plasticity have not been fully elucidated. We reveal Janus kinase (JAK)-signal transducer activator transcription (STAT) signaling is a crucial executor in promoting plasticity-driven androgen receptor (AR)-targeted therapy prostate cancer....
αKlotho is the prototypic member of Klotho family and most highly expressed in kidney. has pleiotropic biologic effects, kidney, its actions include regulation ion transport, cytoprotection, anti-oxidation anti-fibrosis. In rodent models chronic kidney disease (CKD), deficiency been shown to be an early biomarker as well a pathogenic factor. The database for human CKD remains controversial even after years study. We used synthetic antibody library identify high-affinity antigen-binding...
α-Klotho exerts pleiotropic biological actions. Heterozygous haplo-insufficient mice (kl/+) appear normal at baseline except for age-related changes in the lung, suggesting heightened pulmonary susceptibility to deficiency. We used vivo and vitro models test whether protects lung epithelia against injury. Normally, is not expressed but circulating levels are reduced -40% kl/+ undetectable homozygous α-Klotho-deficient (kl/kl). show distal air space enlargement a given airway pressure, with...
Mutations in STK11/LKB1 non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB), and introduction of a Stk11/Lkb1 (L) mutation into murine adenocarcinomas driven by mutant Kras Trp53 loss (KP) resulted an ICB refractory syngeneic KPL tumor. Mechanistically this occurred because NSCLCs lacked TCF1-expressing CD8 T cells, phenotype recapitulated human NSCLCs. Systemic inhibition Axl results increased type I interferon secretion from...
Tumor mutational burden and heterogeneity has been suggested to fuel resistance many targeted therapies. The cytosine deaminase APOBEC proteins have implicated in the signatures of more than 70% human cancers. However, mechanism underlying how cancer cells hijack mediated mutagenesis machinery promote tumor heterogeneity, thereby foster therapy remains unclear. We identify SYNCRIP as an endogenous molecular brake which suppresses APOBEC-driven prostate (PCa). Overactivated APOBEC3B,...
Mulberroside A is a major stilbene glycoside of Morus alba L. (Moraceae), which effectively used for the treatment hyperuricemia and gout in traditional Chinese medicine. We examined whether mulberroside had effects on renal urate underexcretion dysfunction oxonate-induced hyperuricemic mice investigated potential uricosuric nephroprotective mechanisms involved. at 10, 20, 40 mg/kg decreased serum uric acid levels increased urinary excretion fractional mice. Simultaneously, it reduced...
Abstract Background Bear bile powder (BBP), a unique animal-derived medicine with anti-inflammatory and antioxidant effects, is used in Shexiang Tongxin dropping pills (STDP), which applied to treat cardiovascular diseases, including acute myocardial infarction (AMI). The efficacy compatibility mechanisms of action BBP STDP against diseases remain unclear. This study aimed investigate the effects rats AMI. Methods We investigated Non-targeted metabonomics, 16S rRNA analysis, RNA sequencing,...
The Acute Disease Quality Initiative (ADQI) working group recently released a consensus definition of sepsis-associated acute kidney injury (SA-AKI), but the prognosis and risk factors for early late SA-AKI have not been studied. This was retrospective cohort study based on Medical Information Mart Intensive Care IV (MIMIC-IV) database (v2.2). First, patients that met new from ADQI were screened, then, relationships between occurrence time relevant clinical parameters analyzed. After...
Sympathetic vasoconstriction is attenuated in exercising muscle by locally generated vasodilators, including NO. Skeletal also produces reactive oxygen species (ROS), such as superoxide (O(2)(-)), which inactivates We, therefore, hypothesized that excessive ROS production would result enhanced sympathetic muscle. To increase O(2)(-) activating NADPH oxidase, rats underwent chronic infusion of angiotensin II (Ang II) or unilateral renal artery stenosis (2K1C) to endogenous Ang II. At rest,...
αKlotho is a circulating protein that originates predominantly from the kidney and exerts cytoprotective effects in distant sites. We previously showed rodents lung particularly vulnerable to deficiency. Because acute injury common serious complication of (AKI), we hypothesized deficiency AKI contributes injury. To test hypothesis, created by renal artery ischemia-reperfusion rats observed development alveolar interstitial edema increased pulmonary oxidative damage DNA, protein, lipids....
Suboptimal health status (SHS) is a reversible state between ideal and illness it can be effectively reversed by risk prediction, disease prevention, personalized medicine under the global background of predictive, preventive, (PPPM) concepts. More more Chinese nurses have been troubled psychological symptoms (PS). The correlation PS SHS unclear in nurses. purpose current study to investigate prevalence relationship along with predisposing factors as well discuss feasibility improving...
The erythropoietin receptor (EpoR) is widely expressed but its renoprotective action unexplored. To examine the role of EpoR in vivo kidney, we induced acute kidney injury (AKI) by ischemia-reperfusion mice with different bioactivities kidney. bioactivity was reduced knockin wild-type human EpoR, which hypofunctional relative to murine and a renal tubule-specific knockout. These had lower EPO/EpoR activity autophagy flux tubules. Upon AKI induction, they exhibited worse function structural...
Induced pluripotent stem cells (iPSCs) have been reported to alleviate organ injury, although the mechanisms of action remain unclear and administration intact faces many limitations. We hypothesized that cell-free conditioned media (CM) containing secretome iPSCs possess antioxidative constituents can pulmonary oxidant stress damage. derived from human dermal fibroblasts harvested CM. Addition iPSC CM cultured alveolar type-1 epithelial mitigated hyperoxia-induced depletion endogenous total...