A5016214748- Cardiovascular Function and Risk Factors
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Cardiac Health and Mental Health
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Cardiac Ischemia and Reperfusion
- Inflammatory Biomarkers in Disease Prognosis
- Sirtuins and Resveratrol in Medicine
- Microbial Metabolism and Applications
- Cardiac Fibrosis and Remodeling
- Clostridium difficile and Clostridium perfringens research
- Signaling Pathways in Disease
- Ferroptosis and cancer prognosis
- Blood Pressure and Hypertension Studies
- Healthcare Policy and Management
- Pericarditis and Cardiac Tamponade
- Nanoplatforms for cancer theranostics
- Biochemical and Molecular Research
- Carbohydrate Chemistry and Synthesis
- Biomarkers in Disease Mechanisms
- Studies on Chitinases and Chitosanases
- Uterine Myomas and Treatments
- Health, psychology, and well-being
- Genomics, phytochemicals, and oxidative stress
Shantou University
2016-2024
First Affiliated Hospital of Shantou University Medical College
2010-2024
Shenzhen Maternity and Child Healthcare Hospital
2022-2024
Shantou University Medical College
2023
Renmin Hospital of Wuhan University
2016-2021
Wuhan University
2016-2021
First Affiliated Hospital of Bengbu Medical College
2017-2019
Cardiovascular Institute Hospital
2017
Background. Diabetes mellitus (DM) can induce cardiomyocyte injury and lead to diabetic cardiomyopathy (DCM) which presently has no specific treatments consequently increase risk of mortality. Objective. To characterize the therapeutic effect 6-gingerol (6-G) on DCM identify its potential mechanism. Methods. In vivo streptozotocin- (STZ-) induced DM model was established by using a high-fat diet STZ, followed low-dose (25 mg/kg) high-dose (75 6-G intervention. For an in vitro model, H9c2 rat...
Cardiomyocyte apoptosis is a key event in the process of doxorubicin (DOX)-induced cardiotoxicity.Our previous study found that rosmarinic acid (RA) could attenuate pressure overload-induced cardiac dysfunction via fibroblasts (CFs), however its effect DOX-induced cardiotoxicity remains unknown.In present study, mice were subjected to single intraperitoneal injection DOX (15mg/kg) generate cardiotoxicity.Histological examination, echocardiography, and molecular markers used evaluate effects...
Diabetic cardiomyopathy (DCM) is associated with a greater risk of mortality in patients diabetes mellitus. Currently, no specific treatment has been suggested for DCM treatment. This study demonstrated that myricetin (M) attenuated DCM‐associated cardiac injury mice subjected to streptozotocin (SZT) and neonatal rat cardiomyocytes (NRCM) challenged high glucose. In vivo investigation 6 months M (200 mg/kg/d) significantly alleviated hypertrophy, apoptosis, interstitial fibrosis....
Abstract Background The gut microbiota is involved in the pathogenesis of diabetic cardiomyopathy (DCM). Myricetin protects cardiac function DCM. However, low bioavailability myricetin fails to explain its pharmacological mechanisms thoroughly. Research has shown that a positive effect on microbiota. We hypothesize improves development DCM via regulating Methods mice were induced with streptozotocin and fed high-fat diet, then treated by gavage diet for 16 weeks. Indexes related composition,...
BACKGROUND The aim of this study was to develop a novel Poloxamer-based drug delivery system featuring tumor-targeting folate moiety, which expected provide better targeting properties and therapeutic effects compared with the traditional cubosomes (Cubs). MATERIAL AND METHODS Both folate-modified Cubs containing etoposide (ETP-Cubs-FA) normal cubic nanoparticles loaded (ETP-Cubs) were prepared through fragmentation bulk gels under homogenization condition 1500 bar, mean particle size around...
Objective: Geniposide (GE) is a major component in the fruit of Gardenia jasminoides Ellis. Oxidative stress, endoplasmic reticulum (ER) stress and canonical Smad3 pathway are implicated pathogenesis cardiac fibrosis. We aim to investigate protective roles GE pathological Methods: Male C57BL/6 mice induced by isoprenaline (ISO) were used construct model EX-527 was given for 2 weeks detect effects on Levels oxidative ER evaluated Real time (RT)-PCR, Western blots, immunohistochemistry...
Recent investigations have proposed a potential causal association between the occurrence of ferroptosis, nuclear factor kappa B (NF-κB) and ubiquitin-specific protease 24 (USP24). Nevertheless, mechanism USP24 NF-κB regulation ferroptosis in context diabetic cardiomyopathy (DCM) remain unclear. In this study, high-fat diet streptozotocin-induced mouse DCM model were established, high glucose palmitic acid treatment H9c2 cells neonatal primary cardiomyocytes (NMPCs) was used as an vitro...
Suboptimal health status (SHS) is a reversible state between ideal and illness it can be effectively reversed by risk prediction, disease prevention, personalized medicine under the global background of predictive, preventive, (PPPM) concepts. More more Chinese nurses have been troubled psychological symptoms (PS). The correlation PS SHS unclear in nurses. purpose current study to investigate prevalence relationship along with predisposing factors as well discuss feasibility improving...
Background To date, no studies have investigated the correlation between neutrophil-to-lymphocyte ratio (NLR) and long-term risk of mortality in individuals with both coronary heart disease (CHD) hypertension. This study aims to evaluate association NLR all-cause cardiovascular among this patient population. Methods National Death Index (NDI) Health Nutrition Examination Survey (NHANES 2001–2018) were data sources. A nonlinear was shown by restricted cubic spline (RCS) analysis. Using a...
Syringin, extracted from Eleutherococcus senticosus, is a major biologically active component of Chinese herbs. Studies have certified the multiple pharmacological properties syringin. However, role syringin in cardiac hypertrophy and mechanisms involved remain unclear. In this study, aortic banding was performed on mice order to induce hypertrophy, animals were then treated with for 7 weeks. Echocardiography catheter-based measurements hemodynamic parameters evaluate function at 8 weeks...
Recent studies have demonstrated a correlation between intestinal flora and the severity of myocardial infarction as well post-myocardial repair. However, few investigated whether probiotics reduce mortality improve cardiovascular outcomes in patients with acute infarction. In this study, we will conduct randomized controlled trial (RCT) to evaluate effect on in-hospital incidence major adverse events (MACE) (AMI).This is an open-label, randomized, controlled, superiority clinical involving...
Purpose The purpose of this paper is to construct a new algorithm program procedure for medical grey relational method based on SAS software. Design/methodology/approach Based the environment, authors through following methods: construction data set, confirmation comparison sequence and reference sequence, original transformation, calculation coefficient calculating correlation. Findings results show that novel software satisfies properties properly. It also fully confirmed biggest advantage...
To study relevant risk factors of Shenmai injection induced adverse reactions by using Logistic model and ROC curve, made the prediction for occurrence reactions/events. Case data patients treated with were collected prospective, multi-center, large-sample, nested-case control method, in order to analyze injection-induced reactions/events, establish logistic draw receiver operating characteristic (ROC) curve factors. During study, 7632 (including 3 477 males 4 155 females) included, eight...
Purpose The purpose of this paper is to investigate the superior relationship between blood lipid- and cardiovascular disease (CVD)-related hematological parameters using grey relational analysis (GRA). Design/methodology/approach A total 294 individuals who underwent simultaneous routine examination lipid in Physical Examination Center First Affiliated Hospital Shantou University Medical College were included study. Superior GRA was performed find out factor CVD-related lipids. red cell...
Purpose The purpose of this paper is to analyze the influencing factors patients’ financial burden through a case study hospital on public‒private partnerships (PPP) model (Chaonan Minsheng Hospital Guangdong Province) and provide some useful information policymakers for better development hospitals PPP model. Design/methodology/approach There are total six indicators that defined as burden, basing policy “indicators medical quality management control third level large general (2011...
Objective To investigate the therapeutic effect of combined utilization bisoprolol and glutathione (GSH) for attenuating ventricular remodeling Takotsubo cardiomyopathy (TTC) in mice. Methods C57BL/6J male mice with TTC (n=60) were randomly divided into five groups as: (1) saline control group (n=9), 0.5 ml intraperitoneal injection (i.p) once a day; (2) isoprenaline (ISO) (n=11), 50 mg/kg ISO i. p (3) ISO+ (Biso group, n=12), 10 intragastric administration(i.g) (4) GSH (GSH 250 g (5)...
Abstract Background : Recent studies have demonstrated a correlation between intestinal flora and the severity of myocardial infarction as well post-myocardial repair. However, few investigated whether probiotics reduce mortality improve cardiovascular outcomes in patients with acute infarction. In this study, we will conduct randomized controlled trial (RCT) to evaluate effect on in-hospital incidence major adverse events (MACE) (AMI). Methods This is an open-label, randomized, controlled,...
Background: The causal and molecular biological relationship between uterine fibroids (UFs) hypertension are not well known. Rapid growth in many types of tumors leads to hypoxia increased synthesis endothelin-1 (ET-1). As a vasoconstrictive peptide, whether ET-1 could play role UF-related was unclear.Methods: Bidirectional two-sample Mendelian randomization (MR) analysis applied confirm UFs hypertension. UF individuals were divided into groups progressing non-progressing growth, as high low...