A5054455263- Sperm and Testicular Function
- Biochemical effects in animals
- Cancer-related Molecular Pathways
- Knee injuries and reconstruction techniques
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Lower Extremity Biomechanics and Pathologies
- TGF-β signaling in diseases
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Fibroblast Growth Factor Research
- Connexins and lens biology
- Liver physiology and pathology
- Lipid metabolism and biosynthesis
- Cardiac Ischemia and Reperfusion
- Neurological Disorders and Treatments
- Birth, Development, and Health
- Toxin Mechanisms and Immunotoxins
- Modular Robots and Swarm Intelligence
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related gene regulation
- Heavy Metal Exposure and Toxicity
- Agricultural Practices and Plant Genetics
- Prostate Cancer Treatment and Research
- Ginkgo biloba and Cashew Applications
Jinan University
2010-2024
Wenzhou Medical University
2018-2024
Tsinghua University
2024
Harbin University of Science and Technology
2021-2022
Huizhou Central People's Hospital
2021-2022
Cornell University
2022
East China University of Science and Technology
2021
Sun Yat-sen University
2007-2021
Shenzhen Luohu People's Hospital
2017-2019
Shenzhen University
2017-2019
We recently reported that Parkinsonian and dementia phenotypes emerge between 7-12 months of age in tau-/- mice on a Bl6/129sv mixed background. These observations were partially replicated by another group using pure Bl6 background mice, but notably they did not observe cognitive phenotype. A third found impairment at 20-months age. To reconcile the observations, here we considered genetic, dietary environmental variables both studies, performed an extended set behavioral studies 12-month...
Mesenchymal stem cells (MSCs) derived from bone marrow have been shown to differentiate into hepatocytes, which would be an ideal resource for transplantation or artificial liver devices. Here we investigated the efficiency of co-culture system consisting rat MSCs and adult induce differentiation hepatocyte-like cells. Marked were either co-cultured with freshly isolated treated hepatocyte growth factor (HGF) 21 days. In systems, formed spheroids round-shaped while keeping normal...
Osteosarcoma is a high-grade bone sarcoma with strong invasive ability. However, treatment traditional chemotherapeutic drugs limited by low tolerability and side effects. Resveratrol has been reported previously to have selective antitumor effect on various tumor cells while little known about its effects underlying mechanism in osteosarcoma biology. In this study, we found that resveratrol inhibits proliferation glycolysis, induces apoptosis reduces the invasiveness of U2-OS vitro. After...
Background/Aims: Bone marrow stromal cells (BMSCs) are multipotent precursors that give rise to osteoblasts, and contribute directly bone formation. Connexin 43 (Cx43) is the most ubiquitous gap junction protein expressed in cell types, plays crucial roles regulating intercellular signal transmission for development, differentiation pathology. However, precise role mechanism of Cx43 BMSCs less known. Here, we investigate function osteogenic vitro. Methods: were isolated by whole adherent...
The goal of this study was to examine the effects xyloketal B on nonalcoholic fatty liver disease (NAFLD) and explore molecular mechanisms underlying its in both vivo vitro models. We discovered an association between sterol regulatory element-binding protein-1c (SREBP-1c) signaling pathway, which is related lipid metabolism. Mice were dosed with (5, 10 20 mg/kg/d) atorvastatin (15 via intraperitoneal injection once daily for 40 days after being fed a high fat diet plus 10% fructose liquid...
Astragaloside IV (AS-IV), the major pharmacological extract from Astragalus membranaceus Bunge, possesses a variety of biological activities in cardiovascular systems. Here, we aimed to evaluate preclinical evidence and possible mechanism AS-IV for animal models myocardial ischemia/reperfusion (I/R) injury. Studies with I/R injury were identified 6 databases inception May, 2018. The methodological quality was assessed by using CAMARADES 10-item checklist. All data analyzed Rev-Man 5.3...
In the mammalian testis, two distinct populations of Sertoli cells (SCs), immature SCs (ISCs) and adult (ASCs), play significant roles in regulating development function Leydig cells. However, effect different SC types on is poorly understood. Here, our study showed that miR-145-5p expression was significantly at stages, with highest observed ISCs. Exosomes mediate transfer from ISCs to Overexpression downregulated steroidogenic gene inhibited testosterone synthesis. Additionally, functioned...
<b><i>Background:</i></b> Basic fibroblast growth factor (bFGF) has been increasingly investigated due to its neuroprotection in neurodegenerative disorders. Because there are still no cures for any of these disorders, it is crucial identify new therapeutic targets and screen potential drugs. The increased phosphorylation tau at Ser<sup>396</sup> leads intracellular accumulation, which forms neurofibrillary tangles Parkinson's disease (PD). In this study,...
Background: Current treatment of osteosarcoma is limited in part by side effects and low tolerability, problems generally avoided with traditional Chinese medicine. Ganoderma lucidum, a medicine antitumor effects, offers potential alternative, but little known about its molecular mechanisms cells. Objective: To investigate the effect G lucidum on cells mechanism. Methods: Osteosarcoma MG63 U2-OS were treated followed assays for cell proliferation (Cell Counting Kit-8), colony formation,...
Cadmium (Cd) is one of the most common environmental pollutants, which has a long biological half-life. Maternal Cd-exposure in natural environment causes steroidogenesis defects resulting spermatogenesis disorder male offspring. For better understanding its underlying mechanism, we have employed iTRAQ to screen differentially expressed protein and found that expression CORO1A Cofilin 1 was up-regulated approximately 2 fold Leydig cells maternal As major source steroid hormone, cholesterol...
Cholangiocyte proliferation is necessary for biliary recovery from cold ischemia and reperfusion injury (CIRI), but there are few studies on its intracellular mechanism. In this process, the role of rapamycin, a new immunosuppressant used in liver transplantation, still unknown. order to determine whether rapamycin can depress cholangiocyte regeneration by inhibiting signal transducer activator transcription 3 (STAT3) activation, (0.05 mg/kg) was administered rats days before orthotopic...
The modular robot is becoming a prevalent research object in robots because of its unique configuration advantages and performance characteristics. It possible to form configurations with different functions by reconfiguring functional modules. This paper focuses on studying the robot’s design self-reconfiguration process hopes realize industrial application certain extent. We robotic DOF based cellular module hexahedron perform kinematic analysis structure. An innovative reconfiguration...
Abstract Objectives This study explored the response of nasopharyngeal carcinoma cells to TGF-β1-induced growth suppression and investigated roles TGF-β/Smad signaling pathway in cells. Methods The cell line CNE2 were treated with TGF-β1. responses analyzed by MTT assay. mRNA expression protein subcellular localization components determined real time RT-PCR immunocytochemical analysis. Results We found that was not suppressed proteins TβRII, Smad 7 expressed normally, while Smad2, Smad3,...
Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin regulation testicular clearly involved rodents. It essential sperm production. deficiency adversely affects testosterone secretion. Adult Leydig cells are responsible production male. The regulating differentiation still unknown. this study, we explored roles and underlying mechanisms cell differentiation. We found that could regulate affected mice maintained on a A-free diet. This effect...