A5101479842- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Cardiovascular Disease and Adiposity
- Lipid metabolism and biosynthesis
- RNA modifications and cancer
- Mesenchymal stem cell research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Mathematical and Theoretical Epidemiology and Ecology Models
- Autophagy in Disease and Therapy
- Acupuncture Treatment Research Studies
- Tissue Engineering and Regenerative Medicine
- Lipid metabolism and disorders
- Organic Electronics and Photovoltaics
- Healthcare and Venom Research
- Renin-Angiotensin System Studies
- Antioxidant Activity and Oxidative Stress
- Nitric Oxide and Endothelin Effects
Xinjiang University
2007-2025
Hubei Provincial Center for Disease Control and Prevention
2025
University of South China
2015-2025
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
Zhongshan Hospital
2017-2024
Fudan University
2015-2024
Shihezi University
2021-2024
Gansu University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Shihezi University Medical College
2017-2023
The relative balance between the quantity of white and brown adipose tissue can profoundly affect lipid storage whole-body energy homeostasis. However, mechanisms regulating formation, expansion, interconversion these 2 distinct types fat remain unknown. Recently, lysosomal degradative pathway macroautophagy has been identified as a regulator cellular differentiation, suggesting that autophagy may modulate this process in adipocytes. function differentiation was therefore examined current...
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes white adipose tissue (WAT) produces “white adipocytes” with characteristics brown fat and leads to a reduction adiposity its metabolic complications. Although BMP4 is known induce commitment pluripotent stem cells the adipocyte lineage by producing that possess preadipocytes, effects on mature phenotype function were unknown. Forced expression transgene mice gives rise reduced WAT mass size along an increased number cell types...
Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of age, features androgen excess, ovulatory dysfunction, and polycystic ovaries. Despite its high prevalence, specific pharmacologic intervention for PCOS is challenging. In this study, we identified artemisinins as anti-PCOS agents. Our finding demonstrated the efficacy artemisinin derivatives alleviating symptoms both rodent models human patients, curbing hyperandrogenemia through suppression ovarian synthesis....
MicroRNAs are implicated as crucial mediators in metabolic diseases including obesity, diabetes, and non-alcoholic fatty liver (NAFLD). Here, we show miR-27a attenuated hepatic de novo lipogenesis alleviated obesity-initiated NAFLD through inhibiting Fasn Scd1 liver. Hepatic levels of were significantly augmented HFD-fed ob/ob mice. Further studies demonstrated that directly interacted with 3' untranslated region (3'-UTR) mRNAs reduced their expression Adenovirus-mediated overexpression...
Increasing evidence indicates that exposure to microcystin-LR (MC-LR) can cause kidney damage. However, the association between MC-LR and chronic disease (CKD) risk in humans has not been studied. Therefore, we conducted a population-based case–control study involving 135 CKD cases matched controls central China analyzed effects of alone as well combined with known factor cadmium (Cd). Compared lowest quartile exposure, highest had 6.56-fold (95% confidence interval [CI]: 2.46, 17.51)...
Microcystin-LR (MC-LR), a potent hepatotoxin can cause liver damages. However, research on hepatic lipid metabolism caused by long-term exposure to environmental concentrations MC-LR is limited. In the current study, mice were exposed various low of (0, 1, 30, 60, 90, 120 μg/L in drinking water) for 9 months. The general parameters, serum and lipids, tissue pathology, metabolism-related genes proteins investigated. results show that chronic had increased levels triglyceride (TG) total...
Obesity, particularly increased visceral fat, positively correlates with various metabolic challenges, including atherosclerosis, but the mechanism is not fully understood. The aim of this study to determine role visceral-fat-derived exosomes (Exo) in endothelial cells and atherosclerosis. We show that obesity changes miRNA profile adipose mice. Importantly, exosomal miR-27b-3p efficiently enters into vascular activates NF-κB pathway by downregulating PPARα. Mechanistically, binds directly...
Abstract Introduction Despite intensive study of the mechanisms chemotherapeutic drug resistance in human breast cancer, few reports have systematically investigated that underlie to chemotherapy-sensitizing agent tumor necrosis factor (TNF)-α. Additionally, relationship between TNF-α mediated by MEK5/Erk5 signaling and epithelial-mesenchymal transition (EMT), a process associated with promotion invasion, metastasis, recurrence has not previously been investigated. Methods To compare...
Liver coordinates a series of metabolic adaptations to maintain systemic energy balance and provide adequate nutrients for critical organs, tissues cells during starvation. However, the mediator(s) implicated in orchestrating these fasting-induced adaptive responses underlying molecular mechanisms are still obscure. Here we show that hepatic growth differentiation factor 15 (GDF15) is regulated by IRE1α-XBP1s branch promotes fatty acids β-oxidation ketogenesis upon fasting. GDF15 expression...
Next-generation sequencing of the exome and genome prostate cancers has identified numerous genetic alternations. SPOP (Speckle-type POZ Protein) was one most frequently mutated genes in primary cancer, suggesting is a potential driver cancer development progression. However, how mutations contribute to pathogenesis remains poorly understood. acts as an adaptor protein CUL3-RBX1 E3 ubiquitin ligase complex that generally recruits substrates for ubiquitination subsequent degradation....
Background and Aims NAFLD, characterized by aberrant triglyceride accumulation in liver, affects the metabolic remodeling of hepatic nonhepatic tissues secreting altered hepatokines. Small ubiquitin‐related modifier (SUMO)–specific protease 2 (SENP2) is responsible for de‐SUMOylation target protein, with broad effects on cell growth, signal transduction, developmental processes. However, role SENP2 metabolism remains unclear. Approach Results We found that was most dramatically increased...
l-Tetrahydropalmatine (l-THP) is an active ingredients of Corydalis yanhusuo W.T. Wang, which protects against acute global cerebral ischaemia-reperfusion injury. In this study, we show that l-THP cardioprotective in myocardial injury and examined the mechanism. Rats were treated with (0, 10, 20, 40 mg/kg b.w.) for 20 min before occlusion left anterior descending coronary artery subjected to (30 min/6 h). Compared vehicle-treated animals, infarct area/risk area (IA/RA) (20, rats was reduced,...
Oxidative damage is a key factor for the pathogenesis of age‑related macular degeneration (AMD), therefore, anti-oxidative stress valuable method prevention or treatment AMD. The aim present study was to reveal protective mechanism lutein on retinal pigment epithelium (RPE) cells subjected oxidative stress. Acute epithelial 19 (ARPE‑19) were exposed induced by H2O2 following pretreatment. activities caspases, level intracellular reactive oxygen species (ROS) and cell cycle analyzed using...
Abstract The intra‐articular injection of adipose‐derived stem cells ( ASC s) is a novel potential therapy for patients with osteoarthritis OA ). However, the efficacy s from different regions body remains unknown. This study investigated whether subcutaneous or visceral adipose tissue provide same improvement . Mouse and human were excised isolation. Morphology, proliferation, surface markers adipocyte differentiation (S‐ (V‐ analysed. A surgically induced rat model was established, 4 weeks...
Great progress has been made in identifying positive regulators that activate adipocyte thermogenesis, but negative regulatory signaling of thermogenesis remains poorly understood. Here, we found cardiotrophin-like cytokine factor 1 (CLCF1) led to loss brown fat identity, which impaired thermogenic capacity. CLCF1 levels decreased during stimulation were considerably increased obesity. Adipocyte-specific transgenic (CLCF1-ATG) mice showed energy expenditure and severe cold intolerance....
ABSTRACT Background Sepsis and acute respiratory distress syndrome (ARDS) are common inflammatory conditions in intensive care, with ARDS significantly increasing mortality septic patients. PANoptosis, a newly discovered form of programmed cell death involving multiple pathways, plays critical role diseases. This study aims to elucidate the PANoptosis‐related genes (PRGs) their involvement progression sepsis ARDS. Methods analyzed differentially expressed (DEGs) associated PRGs explore...
Organophosphate esters (OPEs) are widely used as flame retardants in most regions, they adversely affect ecosystems and threaten human health. OPEs have attracted significant public attention because toxic ubiquitously present the environment. While China is among world's largest users producers of OPEs, limited data on exposure animal-derived foods to exist; consequently, a method for quantifying food samples needed. In this study, was developed determination eight including triethyl...
Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We investigated growth inhibitory EGCG on human breast line MCF-7, mechanism its action with emphasis regulation survival. A significant dose-dependent inhibition was observed coordinated EGCG-induced apoptosis....
Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they regulated deserves more explorations. In this study, we demonstrate stearoyl-CoA desaturase 1 (SCD1) subcutaneous WAT (scWAT) responded to cold stimulation was able promote mobilization triacylglycerol [TAG (triglyceride)]. vitro studies showed SCD1 promoted lipolysis C3H10T1/2 adipocytes. The lipolytic effect...