A5100424222- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipoproteins and Cardiovascular Health
- Neurological Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Neurological Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Neurosurgical Procedures and Complications
- Functional Brain Connectivity Studies
- Atherosclerosis and Cardiovascular Diseases
- Advanced Neuroimaging Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Neurological and metabolic disorders
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
National Clinical Research Center for Digestive Diseases
2016-2025
Central South University
2009-2025
Center for Excellence in Brain Science and Intelligence Technology
2022-2025
Chinese Academy of Sciences
2005-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Liaoning Technical University
2024-2025
Chinese Institute for Brain Research
2016-2025
Beijing Academy of Artificial Intelligence
2021-2025
Background: China bears the biggest stroke burden in world. However, little is known about current prevalence, incidence, and mortality of at national level, trend past 30 years. Methods: In 2013, a nationally representative door-to-door survey was conducted 155 urban rural centers 31 provinces China, totaling 480 687 adults aged ≥20 All survivors were considered as prevalent cases time (August 31, 2013). First-ever strokes that occurred during 1 year preceding point-prevalent incident...
Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than alone.In randomized, double-blind, placebo-controlled trial conducted at 114 centers in China, we randomly assigned 5170 patients within 24 hours onset of high-risk TIA to combination (clopidogrel an initial dose 300 mg, followed by 75 mg per day for 90 days, plus 21 days) placebo...
Limited data are available to guide the choice of a target for systolic blood-pressure level when treating acute hypertensive response in patients with intracerebral hemorrhage.We randomly assigned eligible participants hemorrhage (volume, <60 cm(3)) and Glasgow Coma Scale (GCS) score 5 or more (on scale from 3 15, lower scores indicating worse condition) 110 139 mm Hg (intensive treatment) 140 179 (standard order test superiority intensive reduction blood pressure standard reduction;...
The relative balance between the quantity of white and brown adipose tissue can profoundly affect lipid storage whole-body energy homeostasis. However, mechanisms regulating formation, expansion, interconversion these 2 distinct types fat remain unknown. Recently, lysosomal degradative pathway macroautophagy has been identified as a regulator cellular differentiation, suggesting that autophagy may modulate this process in adipocytes. function differentiation was therefore examined current...
In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy.We conducted a trial at 41 academic tertiary care centers in China to evaluate thrombectomy with or without patients stroke. Patients stroke from large-vessel occlusion anterior circulation were randomly assigned 1:1 ratio undergo alone (thrombectomy-alone group) preceded by alteplase, dose 0.9 mg per kilogram body weight, administered within...
We aimed to establish the prevalence, characteristics, and outcomes of intracranial atherosclerosis (ICAS) in China by a large, prospective, multicenter study. evaluated 2864 consecutive patients who experienced an acute cerebral ischemia<7 days after symptom onset 22 Chinese hospitals. All underwent magnetic resonance angiography, with measurement diameter main arteries. ICAS was defined as ≥50% reduction on angiography. The prevalence 46.6% (1335 patients, including 261 coexisting...
The role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations. Download PDF the Research Summary. We conducted multicenter, prospective, open-label, randomized trial China involving patients large-vessel occlusion anterior circulation and an Alberta Stroke Program Early Computed Tomography Score 3 to 5 (range, 0 10, lower values indicating larger infarction) or infarct-core volume 70 100 ml. Patients were randomly assigned...
Ticagrelor may be a more effective antiplatelet therapy than aspirin for the prevention of recurrent stroke and cardiovascular events in patients with acute cerebral ischemia.We conducted an international double-blind, controlled trial 674 centers 33 countries, which 13,199 nonsevere ischemic or high-risk transient attack who had not received intravenous intraarterial thrombolysis were considered to have cardioembolic randomly assigned within 24 hours after symptom onset, 1:1 ratio, receive...
Trials have evaluated the use of clopidogrel and aspirin to prevent stroke after an ischemic or transient attack (TIA). In a previous trial, ticagrelor was not better than in preventing vascular events death TIA. The effect combination on prevention has been well studied.We conducted randomized, placebo-controlled, double-blind trial involving patients who had mild-to-moderate acute noncardioembolic stroke, with National Institutes Health Stroke Scale (NIHSS) score 5 less (range, 0 42,...
China faces the greatest challenge from stroke in world. The death rate for cerebrovascular diseases was 149.49 per 100 000, accounting 1.57 million deaths 2018. It ranked third among leading causes of behind malignant tumours and heart disease. age-standardised prevalence incidence 2013 were 1114.8 000 population 246.8 person-years, respectively. According to Global Burden Disease Study 2017, years life lost (YLLs) increased by 14.6%; YLLs due rose highest all 1990 2017. absolute numbers...
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and varying degrees of necroinflammation. Although chronic oxidative stress, inflammatory cytokines, insulin resistance have been implicated in the pathogenesis NAFLD, mechanisms that underlie initiation progression this remain unknown. c-Jun N-terminal kinase (JNK) activated oxidants cytokines regulates hepatocellular injury resistance, suggesting may mediate development steatohepatitis. The presence function JNK...
Rapid socioeconomic progress has greatly affected the lifestyle in China. Consequently, owing to changes, urbanization, and accelerated population aging, risk of cardiovascular diseases (CVD) increased. The incidence CVD been increasing continuously this upward trend is projected continue next decade. growing burden become a major public health issue. Accordingly, since 2005, National Center for Cardiovascular Diseases China directed experts cardiology, neurology, nephrology, diabetes,...
Data are limited regarding the association between CYP2C19 genetic variants and clinical outcomes of patients with minor stroke or transient ischemic attack treated clopidogrel.To estimate clopidogrel-treated attack.Three major alleles (*2, *3, *17) were genotyped among 2933 Chinese from 73 sites who enrolled in Clopidogrel High-Risk Patients Acute Nondisabling Cerebrovascular Events (CHANCE) randomized trial conducted January 2, 2010, to March 20, 2012.Patients acute treatment clopidogrel...
After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke and other vascular events is not well known. In this follow-up to report on 1-year outcomes from registry TIA clinics in 21 countries that enrolled 4789 patients with 2009 through 2011, we examined 5-year events.
Background As a leading cause of severe disability and death, stroke places an enormous burden on the health care system in China. There are limited data pattern current medical practice quality delivery for patients at national level. Aim The nation-wide prospective registry, China National Stroke Registry, will be considered with regard to its design, progress, geographic coverage, hospital patient characteristics. Methods Between September 2007 August 2008, Registry recruited consecutive...
China faces the greatest challenge from stroke in world. According to results Global Burden of Disease Study 2019, there were 3.94 million new cases, 28.76 prevalent cases and 2.19 deaths due 2019. Furthermore, is also leading cause disability-adjusted life-year (DALY) China, number DALYs reached 45.9 Several recent large-scale epidemiological surveys have updated data on pre-existing conditions contributed stroke. The age-adjusted prevalence overweight among Chinese adults aged 18–69 years...
Significance Stroke is a devastating illness second only to cardiac ischemia as cause of death worldwide. Long-time attempts salvage dying neurons and preserve neurological functions via various neuroprotective agents have failed, owing at least in part medical science’s limited knowledge ischemia-induced elements that participate irreversible neurovascular damage. The present study was performed understand the role natural killer (NK) cells, key member innate immune system, stroke. We...