A5047591121- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- MRI in cancer diagnosis
- Colorectal Cancer Surgical Treatments
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Advanced Fluorescence Microscopy Techniques
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Health and Disease Prevention
- Neuroendocrine Tumor Research Advances
- Cancer-related molecular mechanisms research
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- Medical Image Segmentation Techniques
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Lung Cancer Treatments and Mutations
- COVID-19 diagnosis using AI
- Urologic and reproductive health conditions
- Traumatic Brain Injury and Neurovascular Disturbances
Second Military Medical University
2016-2025
Changhai Hospital
2016-2025
Fujian Medical University
2014-2024
PLA Army Engineering University
2021-2024
Fujian Provincial Cancer Hospital
2012-2024
Union Hospital
2024
Shanghai Institute of Hematology
2023
Shanghai Sixth People's Hospital
2016-2023
Shanghai Jiao Tong University
2012-2023
Nanfang Hospital
2023
In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy.We conducted a trial at 41 academic tertiary care centers in China to evaluate thrombectomy with or without patients stroke. Patients stroke from large-vessel occlusion anterior circulation were randomly assigned 1:1 ratio undergo alone (thrombectomy-alone group) preceded by alteplase, dose 0.9 mg per kilogram body weight, administered within...
Accurate prediction of peritoneal metastasis for gastric cancer (GC) with serosal invasion is crucial in clinic. The presence collagen the tumour microenvironment affects cells. Herein, we propose a signature, which composed multiple features serosa derived from multiphoton imaging, to describe extent alterations. We find that high signature significantly associated risk (P < 0.001). A competing-risk nomogram including size, differentiation status and lymph node constructed. demonstrates...
Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental detection associated with prolonged survival, but screening asymptomatic individuals for PDAC using a single test remains unfeasible due to low prevalence potential harms of false positives. Non-contrast computed tomography (CT), routinely performed clinical indications, offers large-scale screening, however, identification non-contrast CT has...
Abstract The current tumour-node-metastasis (TNM) staging system alone cannot provide adequate information for prognosis and adjuvant chemotherapy benefits in patients with gastric cancer (GC). Pathomics, which is based on the development of digital pathology, an emerging field that might improve clinical management. Herein, we propose a pathomics signature (PS GC ) derived from multiple features haematoxylin eosin-stained slides. We find PS independent predictor prognosis. A nomogram...
Lymph node status is the primary determinant in treatment decision making early gastric cancer (EGC). Current evaluation methods are not adequate for estimating lymph metastasis (LNM) EGC.To develop and validate a prediction model based on fully quantitative collagen signature tumor microenvironment to estimate individual risk of LNM EGC.This retrospective study was conducted from August 1, 2016, May 10, 2018, at 2 medical centers China (Nanfang Hospital Fujian Provincial Hospital)....
Abstract Background This study aimed to evaluate the significance of MRI-based radiomics model derived from high-resolution T2-weighted images (T2WIs) in predicting tumor pathological features rectal cancer. Methods A total 152 patients with cancer who underwent surgery without any neoadjuvant therapy between March 2017 and September 2018 were included retrospectively. The scanned using a 3-T magnetic resonance imaging, T2WIs obtained. Lesions delineated, 1029 extracted. Least absolute...
Prior studies have investigated the clinical and imaging factors for hemorrhagic transformation (HT), especially symptomatic intracranial hemorrhage (sICH); however, whether alteplase increases risk of HT after endovascular thrombectomy (EVT) is unknown. This study aimed to assess features associated with HT, sICH, parenchymal hematoma (PH) in patients acute ischemic stroke EVT, without intravenous DIRECT-MT (Direct Intraarterial Thrombectomy Revascularize Acute Ischemic Stroke Patients...
Although certain morphological features depicted by high resolution, multi-contrast magnetic resonance imaging (hrMRI) have been shown to be different between culprit and non-culprit middle cerebral artery (MCA) atherosclerotic lesions, the incremental value of hrMRI define lesions over stenosis has not assessed.Patients suspected with MCA underwent hrMRI. Lumen outer wall were segmented calculate stenosis, plaque burden (PB), volume (PV), length (PL) minimum luminal area (MLA).Data from 165...
Background: Advanced non-small cell lung cancer (NSCLC) patients who harbor anaplastic lymphoma kinase (ALK) rearrangement are sensitive to an ALK inhibitor (crizotinib), but not all ALK-positive benefit equally from crizotinib treatment. We analyze the impact of TP53 mutations on response in with NSCLC. Methods: Sixty-six NSCLC receiving were analyzed. 21 cases detected successfully by next generation sequencing validation FFPE before crizotinib. evaluated 8 relation disease control rate...
To evaluate a quantitative radiomic approach based on high-resolution magnetic resonance imaging (HR-MRI) to differentiate acute/sub-acute symptomatic basilar artery plaque from asymptomatic plaque.Ninety-six patients with stenosis underwent HR-MRI between January 2014 and December 2016. Patients were scanned T1- T2-weighted imaging, as well T1 following gadolinium-contrast injection (CE-T1). The value, area/burden, lumen area, minimal luminal area (MLA), intraplaque haemorrhage (IPH),...
<h3>Importance</h3> Immune checkpoint inhibitors (ICIs) can elicit durable antitumor responses in patients with non–small cell lung cancer (NSCLC), but only 20% to 25% of respond treatment. As important genes the DNA damage response pathway, comutation tumor protein p53 (<i>TP53</i>) and ataxia-telangiectasia mutated (<i>ATM</i>) may be associated genomic instability hypermutation. However, prevalence of<i>TP53</i>and<i>ATM</i>comutation its association ICIs are not fully understood....
To develop and validate a radiomics model for predicting 2019 novel coronavirus (COVID-19) pneumonia.
CT-Based Radiomics Score for Distinguishing Between Grade 1 and 2 Nonfunctioning Pancreatic Neuroendocrine TumorsYun Bian1, Hui Jiang2, Chao Ma1, Li Wang2, Jianming Zheng2, Gang Jin3 Jianping Lu1Audio Available | Share
Background Patients with intracranial atherosclerotic disease (ICAD) have a high frequency of stroke recurrence. However, there has been little investigation into the prognostic value higher‐resolution magnetic resonance imaging (HR‐MRI). Purpose To investigate use plaques features in predicting risk recurrent cerebrovascular ischemic events using HR‐MRI. Study Type Prospective. Population Fifty‐eight patients acute/subacute ( N = 46) or transient attack 12). Field Strength/Sequence A 3.0 T,...
A prospective multicenter validation of the ability 1H magnetic resonance spectroscopic imaging (MRSI) to distinguish cancer from noncancer tissues throughout prostate with histopathology resected organ as standard reference.Institutional review board approval was obtained for all centers and participating patients volunteers provided written informed consent. Ninety-nine 10 age-matched 8 underwent 3-dimensional MRSI an endorectal coil at 1.5 T. Selected voxels were assigned peripheral zone...
Abstract Despite growing appreciation of the importance epigenetics in breast cancer, our understanding epigenetic alterations non-coding RNAs (ncRNAs) cancer remains limited. Here, we explored patterns ncRNAs cancers using published sequencing-based methylome data, primarily focusing on two most commonly studied ncRNA biotypes, long and miRNAs. We observed widely aberrant methylation promoters this abnormal was more frequent than that protein-coding genes. Specifically, intergenic were to...
Purpose Carbon nanoparticles have a strong affinity for the lymphatic system. The purpose of this study was to evaluate feasibility sentinel lymph node biopsy using carbon in early breast cancer and optimize application procedure. Methods Firstly, we performed pilot demonstrate optimized condition nodes (SLNs) detection by investigating 36 clinically negative patients. In subsequent prospective study, 83 patients with were included SLNs nanoparticles. Another detected blue dye. parameters...
Histopathology forms the gold standard for diagnosis of breast cancer. Multiphoton microscopy (MPM) has been proposed to be a potentially powerful adjunct current histopathological techniques. A label-free imaging based on two- photon excited fluorescence and second-harmonic generation is developed differentiating normal tissues, benign, as well cancer tissues. Human biopsies (including human benign tissues ) that are first imaged (fresh, unfixed, unstained) with MPM then processed routine...
<h3>BACKGROUND AND PURPOSE:</h3> Intraplaque hemorrhage within intracranial atherosclerotic plaques identified by high-resolution MR imaging has been studied as a potential marker of stroke risk. However, previous studies only examined arteries with high-grade stenosis (degree stenosis, >50%). This study aimed to ascertain the clinical relevance intraplaque in patients low- and stenotic basilar artery plaques. <h3>MATERIALS METHODS:</h3> Patients (<i>n</i> = 126; mean age, 62 ± 10 years;...