A5019580757- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Studies
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Crystallization and Solubility Studies
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- COVID-19 epidemiological studies
- Colorectal and Anal Carcinomas
- Traditional Chinese Medicine Analysis
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- Peptidase Inhibition and Analysis
- Ammonia Synthesis and Nitrogen Reduction
Jiangxi University of Traditional Chinese Medicine
2016-2025
Fujian Medical University
2016-2025
Nanchang University
2013-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Fujian Provincial Cancer Hospital
2012-2024
China Electronics Technology Group Corporation
2024
Chengdu University of Technology
2023
The University of Texas Health Science Center at Houston
2018
Jiangsu University
2018
Shanghai Advanced Research Institute
2008
The EMBL Nucleotide Sequence Database ( http://www.ebi.ac.uk/embl ), maintained at the European Bioinformatics Institute (EBI) near Cambridge, UK, is a comprehensive collection of nucleotide sequences and annotation from available public sources. database part an international collaboration with DDBJ (Japan) GenBank (USA). Data are exchanged daily between collaborating institutes to achieve swift synchrony. Webin preferred tool for individual submissions sequences, including Third Party...
Despite the critical role of microRNA in inflammatory response, little is known about its function inflammation-induced Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). To investigate potential microRNA146a (miR-146a) ALI, we used lipopolysaccharide (LPS)-induced ALI rat model. Our data revealed that LPS-induced lung injury rats resulted significant upregulation proinflammatory cytokine tumor necrosis factor-alpha (TNF-α), IL-6, IL-1β, and miR-146a expression. LPS...
Abstract The growth and sustainable development of humanity is heavily dependent upon molecular nitrogen (N 2 ) fixation. Herein we discover ambient catalyst-free disproportionation N by water plasma which occurs via the distinctive HONH-HNOH +• intermediate to yield economically valuable nitroxyl (HNO) hydroxylamine (NH OH) products. Calculations suggest that reaction prompted coordination electronically excited with dimer radical cation, (H O) , in its two-center-three-electron...
The debate on whether cross-kingdom gene regulation by orally acquired plant miRNAs is possible has been ongoing for nearly 10 years without a conclusive answer. In this study, we categorized into different groups, namely, extracellular vesicle (EV)-borne miRNAs, extracted herbal decoction-borne synthetic miRNA mimics, and tissue/juice-borne miRNAs. This categorization aimed to simplify the analysis address question more specifically. Our evidence suggests that EV-borne mimics consistently...
// Gen Lin 1 , Xirong Fan Weifeng Zhu 2 Cheng Huang Wu Zhuang Haipeng Xu Xiandong 3 Dan Hu Yunjian Kan Jiang Qian Miao and Chao Li 2, 4 Department of Thoracic Oncology, Fujian Cancer Hospital, Medical University Fuzhou 350014, China Pathology, Molecular Provincial Key Laboratory Translational Medicine, Correspondence to: Li, email: lichao3501@163.com Keywords: non-small cell lung cancer, prognosis, programmed death ligand 1, tumor infiltrating lymphocytes Received: June 20, 2017 Accepted:...
Background: Advanced non-small cell lung cancer (NSCLC) patients who harbor anaplastic lymphoma kinase (ALK) rearrangement are sensitive to an ALK inhibitor (crizotinib), but not all ALK-positive benefit equally from crizotinib treatment. We analyze the impact of TP53 mutations on response in with NSCLC. Methods: Sixty-six NSCLC receiving were analyzed. 21 cases detected successfully by next generation sequencing validation FFPE before crizotinib. evaluated 8 relation disease control rate...
Taurine (Tau), the most abundant free amino acid in humans has numerous potential health benefits through its antioxidant and anti‑inflammatory properties. However, limited studies have assessed effect on tumors antitumor mechanism remains unknown. The present study investigated cellular molecular changes induced by Tau, leading to induction of apoptosis human breast cancer cell lines MCF‑7 MDA‑MB‑231. is p53 proficient (p53+/+) MDA‑MB‑231 a null mutant (p53-/-). Cell proliferation viability...
Histopathology forms the gold standard for diagnosis of breast cancer. Multiphoton microscopy (MPM) has been proposed to be a potentially powerful adjunct current histopathological techniques. A label-free imaging based on two- photon excited fluorescence and second-harmonic generation is developed differentiating normal tissues, benign, as well cancer tissues. Human biopsies (including human benign tissues ) that are first imaged (fresh, unfixed, unstained) with MPM then processed routine...
<h3>BACKGROUND AND PURPOSE:</h3> Patients with type 2 diabetes mellitus have considerably higher risk of developing cognitive impairment and dementia. WM changes in these patients been reported. Our aim was to demonstrate that gradual continuous change the associated decline can be captured by DTI parameters, which used complement neuropsychological test scores identifying without mild impairment. <h3>MATERIALS METHODS:</h3> Forty-two mellitus, divided into a group (<i>n</i> = 20) normal...
An amphiphilic fluorescent probe (BHSMP) with aggregation-induced emission (AIE) features was synthesized via a one-step route.
5-Hydroxymethylcytosine (5hmC) modification represents a significant epigenetic within DNA, playing pivotal role in range of biological processes associated with various types cancer. The 5hmC systemic anaplastic large cell lymphoma (ALCL) has not been thoroughly investigated. This study aims to examine the function advancement ALCL. Formalin-fixed, paraffin-embedded (FFPE) tumor tissues (n = 46) were obtained from ALCL patients. GEO dataset was used analyze expression 5hmC-relative enzymes....
Given the resistance to conventional treatments and limitations of immune checkpoint blockade therapy in hepatocellular carcinoma (HCC), it is imperative explore novel prognostic models biomarkers. The dependence cancer cell on exogenous methionine, known as Hoffman effect, a hallmark HCC, with numerous studies reporting strong correlation between methionine metabolism tumor development. Betaine-homocysteine S-methyltransferase (BHMT), critical component pathway, has polymorphisms linking...
Autoimmune diseases (ADs), such as Graves' disease (GD), Hashimoto's thyroiditis (HT), psoriasis, systemic lupus erythematosus (SLE), and type 1 diabetes (T1D), involve complex immune inflammatory responses. This study employed Mendelian randomization (MR) analysis using genome-wide association (GWAS) data to examine the causal relationships among 91 circulating proteins, 41 cytokines, 211 gut microbiota, 731 cell traits in relation ADs. Additionally, we integrated mediation bioinformatics...
Different anti-PD-1 and anti-PD-L1 antibodies bind different epitopes. However, whether the results from SP142 22C3 immunochemistry (IHC) assays can be interchanged to determine patient eligibility for immunotherapy remains largely unknown. Histologic sections 135 tumor samples were probed with both antibodies. The concordance of PD-L1 expression determined by two was assessed. Additionally, we evaluated association detected clinicopathological features prognosis. In total, 105 (77.78%)...