A5103240723- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Photoreceptor and optogenetics research
- Aluminum Alloy Microstructure Properties
- Seismic Imaging and Inversion Techniques
- Aluminum Alloys Composites Properties
- Pharmacological Effects of Natural Compounds
- Phytoestrogen effects and research
- Hydraulic Fracturing and Reservoir Analysis
- Surfactants and Colloidal Systems
- Optimization and Packing Problems
- Advanced Manufacturing and Logistics Optimization
- Hydrocarbon exploration and reservoir analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Microstructure and mechanical properties
- Advanced Drug Delivery Systems
- Natural product bioactivities and synthesis
- Biochemical effects in animals
- Crystallography and molecular interactions
- Molecular spectroscopy and chirality
- Advanced Fluorescence Microscopy Techniques
- Nonlinear Dynamics and Pattern Formation
- CO2 Reduction Techniques and Catalysts
- Mass Spectrometry Techniques and Applications
- Ginseng Biological Effects and Applications
Hebei Medical University
2022-2025
Third Hospital of Hebei Medical University
2025
Jiangxi University of Traditional Chinese Medicine
2019-2024
Wuhan Ship Development & Design Institute
2024
China University of Petroleum, East China
2024
Changchun Institute of Applied Chemistry
2024
Chinese Academy of Sciences
2024
University of Science and Technology of China
2024
Ludong University
2022
China University of Petroleum, Beijing
2018-2020
Look fast Organisms from bacteria to humans sense and react light. Proteins that contain the light-sensitive molecule retinal couple absorption of light conformational changes produce a signal or move ions across membrane. Nogly et al. used an x-ray laser probe earliest structural chromophore within microcrystals ion pump bacteriorhodopsin (see Perspective by Moffat). The excited-state wiggles but is held in place so only one double bond capable isomerizing. A water adjacent proton-pumping...
Kudzu is a traditional medicinal dietary supplement, and recent research has shown its significant benefits in the prevention/treatment of type 2 diabetes mellitus (T2DM). Starch one main substances that contribute decisively to treatment T2DM. However, underlying mechanism hypoglycemic activity not clear. In this study, effect resistant starch supplementation on insulin resistance, gut physical barrier, microbiota was investigated T2DM mice. The result showed could significantly decrease...
In this paper, as an active ingredient, puerarin chitosan nanoparticles (Pur-CS/TPP-NPs) are prepared by ionic gelation method. The (CS) concentration, pH of the CS solution, sodium tripolyphosphate (TPP) stirring speed, time, ultrasonic power, and dosage used single factors for investigation, encapsulation efficiency, drug loading capacity, particle size, polydispersity index (PDI) indicators investigation. optimal prescription is determined using Box–Behnken effect surface design...
Hypertension is a clinical cardiovascular syndrome characterized by elevated systemic arterial pressure with or without multiple risk factors. Radix Pueraria (RP) has the effects of anti-myocardial ischemia, anti-arrhythmia, vasodilatation, blood reduction, anti-inflammation and attenuating insulin resistance. Although RP can be effective for treatment hypertension, its active compounds, drug targets, exact molecular mechanism are still unclear. In this study, systems pharmacology was used...
CO2 electroreduction is an alluring technology for high-value utilization and intermittent electrical energy storage. Self-supporting catalysts with high efficiency have clear advantages over powder ones in electrode construction but still lack effective synthesis methods. In this work, a self-supporting BiCu/carbon hybrid nanofiber membrane (BiCu/CHNM) was synthesized by electrospinning-calcination employed directly as working flow cell to formate Faradaic of 87.67% at partial current...
ABSTRACT We present here a comparison between two statistical methods for facies classifications: Bayesian classification and expectation–maximization method. The can be performed using multiple seismic attributes extended from well logs to three‐dimensional volumes. In this work, we propose, both methods, sensitivity study investigate the impact of choice used condition classification. second part, integrate in inversion setting estimation continuous rock properties, such as porosity...
It is necessary to prepare porous lactose in order improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels preparing lactose. Then, physical properties were profoundly characterized. Finally, also employed health functional food/drug carrier explore effect on curcumin. The results confirmed that (i) successfully prepared using PVP agent; (ii) significantly improved...
The protection of unstable anticancer molecules and their delivery to lesions are challenging issues in cancer treatment. Topotecan (TPT), a classic cytotoxic drug, is widely used for treating refractory lung cancer. However, the therapeutic effects TPT jeopardized by its active lactone form that intrinsically hydrolyzed physiological fluids, resulting low bioavailability. Herein, TPT-loaded crosslinked cyclodextrin metal-organic framework (TPT@CL-MOF) was engineered improve local...
Structural information of the different conformational states two prototypical light-sensitive membrane proteins, bacteriorhodopsin and rhodopsin, has been obtained in past by X-ray cryo-crystallography cryo-electron microscopy. However, these methods do not allow for structure determination most intermediate conformations. Recently, potential X-Ray Free Electron Lasers (X-FELs) tracking dynamics light-triggered processes pump-probe serial femtosecond crystallography demonstrated using...
The self-assembly of a nonionic triblock copolymer (F127) and surfactant (HS15) has been investigated due to favorable changes in properties their mixtures. effect the mixing ratio on process structural stability mixtures was studied by coarse-grained molecular dynamic simulation (CGMD) experimental measurements (transmission electron microscopy, light scattering measurement, drug loading analysis, fluorescence spectroscopy measurement). CGMD provided information behavior. microstructure...
The unique pharmaceutical methods for the processing of botanical drugs according to theory traditional Chinese medicine (TCM) affect clinical syndrome differentiation and treatment. objective this study was comprehensively elucidate principles mechanisms an herbal method by investigating alterations in metabolites Rhizoma Atractylodis Macrocephalae (AMR) processed Aurantii Fructus Immaturus (AFI) decoction determine how these changes enhance efficacy aqueous extracts treating functional...
Abstract The flow regime transitions of the riser and downcomer in an internal‐loop airlift reactor are investigated. Analysis effects mean value, standard deviation chaotic time series on pressure fluctuation signals is recorded to determine transition hydrodynamics reactor. Two major invariants, correlation dimension largest Lyapunov exponent, employed indicate transitions. determined by sudden increase decrease which computed obtained varying gas velocity. determination invariants...
Rhodopsin is a membrane protein from the G protein-coupled receptor family. Together with its ligand retinal, it forms visual pigment responsible for night vision. In order to perform ultrafast dynamics studies, time-resolved serial femtosecond crystallography method required owing nonreversible activation of rhodopsin. such an approach, microcrystals in suspension are delivered into X-ray pulses free-electron laser (XFEL) after precise photoactivation delay. Here, millilitre batch...
Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and show clearly its method of action, we managed did an in-depth discussion. Network pharmacology research very suitable for the analysis multiple components, targets, pathways Traditional Chinese Medicine (TCM). According relevant theory, first carefully collected screened active ingredients in ZSS received 11 that may work. The targets going along with these components were also strongly related insomnia 108...