A5101528778- Catalytic C–H Functionalization Methods
- Quinazolinone synthesis and applications
- RNA Interference and Gene Delivery
- Radical Photochemical Reactions
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Cancer therapeutics and mechanisms
- Synthesis and Catalytic Reactions
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cyclopropane Reaction Mechanisms
- Cancer-related molecular mechanisms research
- Advanced Polymer Synthesis and Characterization
- Synthesis and Biological Evaluation
- Dendrimers and Hyperbranched Polymers
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Lipid Membrane Structure and Behavior
- Traditional Chinese Medicine Analysis
- Flame retardant materials and properties
- Natural product bioactivities and synthesis
- Hydrogels: synthesis, properties, applications
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
Yunnan University
2015-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Hebei University
2025
Chinese Academy of Sciences
2005-2024
Shanghai University
2024
Wenzhou Medical University
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2015-2024
Affiliated Hospital of Nantong University
2023-2024
Institute of High Energy Physics
2024
Nantong University
2023-2024
Cryptococcosis is caused by either Cryptococcus neoformans or C. gattii. While cryptococcal meningoencephalitis mostly in immunocompromised patients, the risk factors remain unclear for patients with no known immune defect. Recently, anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibodies were detected plasma of seven "immunocompetent" cryptococcosis and strains from these reported as (three strains), gattii (one strain), not identified to species level). We all three...
MicroRNAs (miRNAs) have recently been recognized to play an important role in bone-associated diseases. This study aims explore the expression profile and biological function of miR-217, which is known be related tumor cell proliferation migration, osteogenic differentiation MSCs from patients with steroid-associated osteonecrosis (ONFH). Bone marrow was obtained proximal femur 10 ONFH femoral neck fractures. marrow-derived mesenchymal stem cells (MSCs) were isolated cultured. The profile,...
Aim: Delivery of doxorubicin could be achieved by a novel micellar system based on β-cyclodextrin-centered star-shaped amphiphilic polymers (sPEL/CD). This study specifically explored the effect polylactide segments in sPEL/CD various micelle properties, such as critical concentration, size, drug loading, cytotoxicity and resistance reversing effect. Method: The was synthesized arm-first method. concentrations polymeric micelles were determined fluorescence spectrophotometry using pyrene...
In Brief Recent studies reported the translocator protein (TSPO) to play critical roles in several kinds of neurological diseases including inflammatory and neuropathic pain. However, precise mechanism remains unclear. This study was undertaken explore distribution possible spinal TSPO against chronic pain (CNP) a rat model L5 nerve ligation (SNL). Our results showed that upregulated time-related manner dorsal horn after SNL. Spinal predominately expressed astrocytes. A single intrathecal...
Many studies demonstrated unique microRNA profiles in lung cancer. Nonetheless, the role and related signal pathways of miR-375 cancer are largely unknown. Our study investigated relationships between carcinogenesis adenocarcinoma, squamous cell carcinoma small to identify new molecular targets for treatment. We evaluated 723 microRNAs microdissected cancerous cells adjacent normal from 126 snap-frozen specimens using microarrays. validated expression its 22 putative target mRNAs an...
Sodium metal batteries, known for their high theoretical specific capacity, abundant reserves, and promising low-temperature performance, have garnered significant attention. However, the large ionic radius of Na
Polymeric nanoparticles have been extensively studied as drug carriers. Chitosan and its derivatives attracted significant attention in this regard but limited application because of insolubility biological solution. In work, we attempted to utilize cholesterol-modified glycol chitosan (CHGC) self-aggregated increase aqueous solubility, reduce side effects enhance the antitumour efficacy anticancer doxorubicin. Methods CHGC were loaded with doxorubicin by a dialysis method, their...
Combination chemotherapy is a common clinical practice in cancer treatment. Here, cyclic RGD (arginylglycylaspartic acid) peptide was introduced to the surface of lipid/calcium/phosphate (LCP) asymmetric lipid layer nanoparticles for co-delivery paclitaxel (PTX) and gemcitabine monophosphate (GMP) (P/G-NPs). The sphere-like morphology P/G-NPs displays well-distributed particle size, high entrapment efficiency drug loading both PTX GMP, with positive zeta potential. were stable up 15 days....
A procedure was developed for the synthesis of fluorinated 2-aminopyridines based on reactions 1,1-enediamines, benzaldehydes and 1,3-dicarbonyl compounds.
Herein, we report the development of iron-catalyzed benzylic C-H oxidative amidation reactions via photoinduced ligand-to-metal charge transfer (LMCT). These exhibit a broad substrate scope (60 examples) and offer operationally simple, scalable procedures for accessing valuable products from methylarenes in single step. Mechanistic studies control experiments confirm participation photogenerated chlorine radical facilitating hydrogen atom (HAT) bond to initiate reaction.
Transition-metal-catalyzed transfer of a carbene group via in situ generated carbenoid intermediates from α-diazocarbonyls is powerful method for initiating diverse cascade sequences that rapidly lead to the generation structural complexity. Despite significant advancements carbenoid-enabled catalytic pathways, such as insertions and cyclopropane formation, there has been limited exploration selective control processes involving chemistry. In this study, we reported metal-carbenoid-mediated...
Rationale: Effective treatment for lung cancer requires accuracy in subclassification of carcinoma subtypes.Objectives: To identify microRNAs bronchial brushing specimens discriminating small cell (SCLC) from non–small (NSCLC) and further differentiating squamous (SQ) adenocarcinoma (AC).Methods: Microarrays were used to screen 723 laser-captured, microdissected cells 82 snap-frozen surgical specimens. Quantitative reverse-transcriptase polymerase chain reaction was performed on 153...
Vascular endothelial growth factor receptor-2 (VEGFR-2) kinase inhibition is a well-established strategy to promptly tackle tumor by suppression of angiogenesis. We report herein series 5-anilinoquinazoline derivatives substituted 1,3-disubstituted urea. All the newly synthesized compounds described were evaluated for VEGFR-2 and antiproliferative activity against various cancer cells. The novel 1-aryl, 3-aryl-disubstituted urea quinazolines effective inhibitors with in vitro IC50 values...