A5002288726- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Flame retardant materials and properties
- biodegradable polymer synthesis and properties
- Synthesis and properties of polymers
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Drug Transport and Resistance Mechanisms
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- Immunotherapy and Immune Responses
- Genetic and Kidney Cyst Diseases
- Virus-based gene therapy research
- Luminescence and Fluorescent Materials
- TGF-β signaling in diseases
- Hepatitis B Virus Studies
- Graphene and Nanomaterials Applications
- Polymer Surface Interaction Studies
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Extracellular vesicles in disease
- Neural dynamics and brain function
- Zeolite Catalysis and Synthesis
University of New Hampshire
2016-2025
Ministry of Education of the People's Republic of China
2014-2024
Zhejiang University
2015-2024
University of New Hampshire at Manchester
2024
Canadian Nuclear Laboratories
2015-2022
Qingdao University of Science and Technology
2016-2021
Hangzhou Xixi hospital
2014-2021
Central South University
2018-2021
Chemical Synthesis Lab
2015-2021
XinHua Hospital
2021
Currently, not much is known about neuronal positioning and the roles of primary cilia in postnatal neurodevelopment. We show that principal neurons undergo marked changes orientation, concurrent with neuron mouse cerebral cortex. Primary early- late-born compact layers display opposite orientations, while loose laminae are predominantly oriented toward pia. In contrast, astrocytes interneurons, nucleated brain regions do specific directionality. further discovered cell bodies inside-out...
Spinal muscular atrophy (SMA) is a kind of neuromuscular disease characterized by progressive motor neuron loss in the spinal cord. It caused mutations survival 1 (SMN1) gene. SMN1 has paralogous gene, 2 (SMN2), humans that present almost all SMA patients. The generation and genetic correction patient-specific induced pluripotent stem cells (iPSCs) viable, autologous therapeutic strategy for disease. Here, c-Myc-free non-integrating iPSCs were generated from urine an patient using episomal...
Abstract: Therapeutics based on proteins and peptides have profoundly transformed the landscape of treatment for diseases, from diabetes mellitus to cancers, yet short half-life low bioavailability therapeutic hinder their wide applications. To break through this bottleneck, biomolecules-loaded polymersomes with strong adjustability versatility attracted more attentions recently. Loading or into is first but extremely important step towards developing high-quality formulation products....
The structural parameters, thermal properties, and transport properties of three type I clathrates, namely ${\mathrm{Sr}}_{8}{\mathrm{Zn}}_{8}{\mathrm{Ge}}_{38}$, ${\mathrm{Sr}}_{8}{\mathrm{Ga}}_{16}{\mathrm{Ge}}_{30}$, ${\mathrm{Ba}}_{8}{\mathrm{Ga}}_{16}{\mathrm{Si}}_{30}$, have been determined at or below room temperature. parameters these clathrates were by powder neutron diffraction. Their lattice expansion is two to four times greater than that the diamond phases silicon germanium,...
Aim: Indocyanine green (ICG) is a promising near-infrared (NIR) dye for tumor imaging and photothermal therapy; however, the poor stability lack of targeting limit its application. In this study, ICG was encapsulated into folate-conjugated poly(2-ethyl-2-oxazoline)-b-poly(ε-caprolactone) micelles to overcome these problems. Materials & methods: ICG-loaded were prepared by solvent evaporation method. Cell uptake in vitro cytotoxicity evaluated on KB cells. vivo NIR therapy conducted...
Drug leakage in blood circulation is generally a serious concern to polymersomes when loading water‐soluble chemotherapeutics. If packing density of polymersome membrane strengthened, premature drug release will be inhibited. Therefore, synthesis series amphiphilic polyphosphazenes (PNPs) with 2‐diethylaminoethyl 4‐aminobenzoate (DEAB) as hydrophobic side groups and amino‐terminal poly(ethylene glycol) (NH 2 ‐PEG 2000 ) hydrophilic chains presented. By controlling the ratio DEAB NH , optimal...